Reds vs Cardinals Prediction, Odds, Moneyline, Spread & Over/Under for May 1

Odds updated as of 2:12 a.m.

The Thursday schedule in MLB includes a matchup between the Cincinnati Reds and the St. Louis Cardinals.

Before you do any MLB betting on this game at FanDuel Sportsbook, here's what you need to know.

Reds vs Cardinals Game Info

• Cincinnati Reds (16-15) vs. St. Louis Cardinals (14-17)
• Date: Thursday, May 1, 2025
• Time: 12:40 p.m. ET
• Venue: Great American Ball Park -- Cincinnati, Ohio
• Coverage: FDSOH and FDSMW

Reds vs Cardinals Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: CIN: (-124) | STL: (+106)
• Spread: CIN: -1.5 (+164) | STL: +1.5 (-200)
• Total: 8.5 -- Over: (-122) | Under: (-100)

Reds vs Cardinals Probable Starting Pitchers

Probable Pitchers: Andrew Abbott (Reds) - 2-0, 3.60 ERA vs Matthew Liberatore (Cardinals) - 2-2, 3.19 ERA

The probable starters are Andrew Abbott (2-0) for the Reds and Matthew Liberatore (2-2) for the Cardinals. Abbott's team is 2-1-0 against the spread in his starts this season. Abbott's team is 2-0 this season when he starts and they're favored on the moneyline. The Cardinals are 1-4-0 ATS in Liberatore's five starts with a set spread. The Cardinals were the underdog on the moneyline for two Liberatore starts this season -- they split the games.

Reds vs Cardinals Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Cardinals win (50.4%)

Reds vs Cardinals Moneyline

• The Reds vs Cardinals moneyline has Cincinnati as a -124 favorite, while St. Louis is a +106 underdog on the road.

Reds vs Cardinals Spread

• The Cardinals are at the Reds, and are +1.5 on the runline. The Cardinals are +164 to cover the spread, and the Reds are -200.

Reds vs Cardinals Over/Under

• A total of 8.5 runs has been set for the Reds-Cardinals contest on May 1, with the over available at -122 and the under at -100.

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Reds vs Cardinals Betting Trends

• The Reds have come away with nine wins in the 15 contests they have been listed as the favorites in this season.
• Cincinnati has a record of 6-3 when favored by -124 or more this year.
• The Reds' games have gone over the total in 14 of their 31 opportunities.
• The Reds are 17-14-0 against the spread in their 31 games with a line set by sportsbooks this season.
• The Cardinals have won 10 of the 22 games they were the underdog on the moneyline this season (45.5%).
• St. Louis has gone 4-8 when it has played as a moneyline underdog with odds of +106 or longer (33.3%).
• The Cardinals have combined with opponents to hit the over on the total 16 times this season for a 16-13-2 record against the over/under.
• The Cardinals have covered 45.2% of their games this season, going 14-17-0 against the spread.

Reds Player Leaders

• Elly De La Cruz leads Cincinnati in slugging percentage (.438) thanks to nine extra-base hits. He has a .281 batting average and an on-base percentage of .348.
• Among all qualifying batters, he ranks 39th in batting average, his on-base percentage ranks 55th, and he is 60th in slugging.
• De La Cruz has recorded a base hit in 14 straight games. During his last 10 outings he is hitting .368 with a double, a home run, four walks and three RBI.
• TJ Friedl has six doubles, a triple, a home run and 10 walks. He's batting .275 and slugging .367 with an on-base percentage of .333.
• Among qualifying batters, his batting average places him 47th, his on-base percentage 68th, and his slugging percentage 111th.
• Gavin Lux leads his team in OBP (.416) and total hits (32) this season.
• Austin Hays is batting .365 with a .431 OBP and 13 RBI for Cincinnati this season.

Cardinals Player Leaders

• Lars Nootbaar has put up an on-base percentage of .400, a team-high for the Cardinals. He's batting .263 and slugging .439.
• Including all qualifying hitters in MLB, he is 66th in batting average, 15th in on-base percentage and 58th in slugging percentage.
• Brendan Donovan's 38 hits and .491 slugging percentage both pace his team. He has a batting average of .333 with an on-base percentage of .379.
• Including all qualifying hitters, he is fifth in batting average, 25th in on-base percentage and 36th in slugging percentage.
• Nolan Arenado is batting .243 with nine doubles, three home runs and 14 walks.
• Victor Scott II is hitting .271 with five doubles, a triple, two home runs and 10 walks.

Reds vs Cardinals Head to Head

• 4/30/2025: 9-1 STL (Favorite: Reds, Spread: -1.5, Total: 9.5, Favorite Moneyline: -116, Underdog Moneyline: -102)
• 4/30/2025: 6-0 STL (Favorite: Reds, Spread: -1.5, Total: 9, Favorite Moneyline: -154, Underdog Moneyline: +130)
• 4/28/2025: 3-1 CIN (Favorite: Reds, Spread: -1.5, Total: 9.5, Favorite Moneyline: -120, Underdog Moneyline: +102)
• 9/12/2024: 6-1 STL (Favorite: Cardinals, Spread: -1.5, Total: 7.5, Favorite Moneyline: -152, Underdog Moneyline: +128)
• 9/11/2024: 2-1 STL (Favorite: Cardinals, Spread: -1.5, Total: 8, Favorite Moneyline: -146, Underdog Moneyline: +124)
• 9/10/2024: 3-0 CIN (Favorite: Cardinals, Spread: -1.5, Total: 8.5, Favorite Moneyline: -134, Underdog Moneyline: +114)
• 8/14/2024: 9-2 CIN (Favorite: Cardinals, Spread: -1.5, Total: 9.5, Favorite Moneyline: -118, Underdog Moneyline: -100)
• 8/13/2024: 4-1 CIN (Favorite: Reds, Spread: -1.5, Total: 8.5, Favorite Moneyline: -132, Underdog Moneyline: +112)
• 8/12/2024: 6-1 CIN (Favorite: Cardinals, Spread: -1.5, Total: 8.5, Favorite Moneyline: -138, Underdog Moneyline: +118)
• 6/30/2024: 2-0 STL (Favorite: Cardinals, Spread: -1.5, Total: 7.5, Favorite Moneyline: -120, Underdog Moneyline: +102)

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