Reds vs Astros Prediction, Odds, Moneyline, Spread & Over/Under for May 8

Odds updated as of 1:11 a.m.

The Cincinnati Reds versus the Houston Astros is on the MLB schedule for Friday.

Before you do any MLB betting on this matchup at FanDuel Sportsbook, here's what you need to know.

Reds vs Astros Game Info

• Cincinnati Reds (20-18) vs. Houston Astros (15-23)
• Date: Friday, May 8, 2026
• Time: 6:10 p.m. ET
• Venue: Great American Ball Park -- Cincinnati, Ohio
• Coverage: Reds.TV and SCHN

Reds vs Astros Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: CIN: (-130) | HOU: (+110)
• Spread: CIN: -1.5 (+152) | HOU: +1.5 (-184)
• Total: 9.5 -- Over: (-105) | Under: (-115)

Reds vs Astros Probable Starting Pitchers

Probable Pitchers: Nick Lodolo (Reds) - 0-0, 0.00 ERA vs Mike Burrows (Astros) - 1-4, 5.97 ERA

The probable pitchers are Nick Lodolo for the Reds and Mike Burrows (1-4) for the Astros. Lodolo and his team were 15-12-0 against the spread when he pitched last season. Lodolo appeared in 13 games last season as the moneyline favorite and his team finished with a record of 8-5 in those contests. The Astros have a 1-6-0 record against the spread in Burrows' starts. The Astros are 1-3 in Burrows' four starts this season that they were the moneyline underdog.

Reds vs Astros Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Reds win (51.5%)

Reds vs Astros Moneyline

• Looking at the moneyline for Astros-Reds, Houston is the underdog at +110, and Cincinnati is -130 playing at home.

Reds vs Astros Spread

• The Reds are 1.5-run home favorites on the runline against the Astros. The Reds are +152 to cover, and the Astros are -184.

Reds vs Astros Over/Under

• The Reds-Astros game on May 8 has been given an over/under of 9.5 runs. The over is set at -105 and the under at -115.

Bet on Cincinnati Reds vs. Houston Astros on FanDuel today!

Reds vs Astros Betting Trends

• The Reds have come away with six wins in the 10 contests they have been listed as the favorites in this season.
• This year Cincinnati has won four of seven games when listed as at least -130 on the moneyline.
• The Reds' games have gone over the total in 22 of their 36 opportunities.
• The Reds have posted a record of 22-14-0 against the spread this season.
• The Astros have won nine of the 21 games they were the underdog on the moneyline this season (42.9%).
• When it has played as a moneyline underdog with odds of +110 or longer, Houston has gone 7-10 (41.2%).
• In the 38 games oddsmakers have set an over/under for the Astros, they have combined with opponents to go over the total 25 times (25-12-1).
• The Astros have put together a 15-23-0 record ATS this season (covering only 39.5% of the time).

Reds Player Leaders

• Sal Stewart has six doubles, 10 home runs and 20 walks while batting .245. He has an on-base percentage of .333 and a slugging percentage of .497.
• Among qualifying hitters in MLB, he ranks 93rd in batting average, 90th in on-base percentage, and 34th in slugging.
• Elly De La Cruz has 40 hits and an OBP of .337 to go with a slugging percentage of .510. All three of those stats are tops among Cincinnati hitters this season. He's batting .265.
• Among qualifying hitters, his batting average places him 60th, his on-base percentage 85th, and his slugging percentage 28th.
• Spencer Steer has collected 31 base hits, an OBP of .333 and a slugging percentage of .451 this season.
• Steer brings a 10-game hitting streak into this game. In his last 10 games he is batting .353 with a double, two home runs, five walks and six RBIs.
• Nathaniel Lowe has been key for Cincinnati with 20 hits, an OBP of .349 plus a slugging percentage of .581.

Astros Player Leaders

• Yordan Alvarez has racked up a team-best OBP (.423) and slugging percentage (.638), and leads the Astros in hits (45, while batting .319).
• Including all qualifying hitters, he is 11th in batting average, while his on-base percentage ranks fifth and he is sixth in slugging.
• Christian Walker has nine doubles, nine home runs and 15 walks while batting .307. He's slugging .569 with an on-base percentage of .381.
• Including all qualifying players, he is 20th in batting average, 25th in on-base percentage and 11th in slugging percentage.
• Jose Altuve has nine doubles, three home runs and 17 walks while batting .241.
• Isaac Paredes has six doubles, three home runs and 13 walks while hitting .265.

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