Rays vs Guardians Prediction, Odds, Moneyline, Spread & Over/Under for Sept. 4

Odds updated as of 10:12 a.m.

The Tampa Bay Rays will take on the Cleveland Guardians in MLB action on Thursday.

Before checking out the MLB betting lines on FanDuel Sportsbook, we've got you covered, in terms of the most important information regarding this matchup.

Rays vs Guardians Game Info

• Tampa Bay Rays (70-69) vs. Cleveland Guardians (69-69)
• Date: Thursday, September 4, 2025
• Time: 7:35 p.m. ET
• Venue: George M. Steinbrenner Field -- Tampa, Florida
• Coverage: FDSSUN and CLEG

Rays vs Guardians Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: TB: (-162) | CLE: (+136)
• Spread: TB: -1.5 (+126) | CLE: +1.5 (-152)
• Total: 8.5 -- Over: (-106) | Under: (-114)

Rays vs Guardians Probable Starting Pitchers

Probable Pitchers: Ryan Pepiot (Rays) - 10-10, 3.70 ERA vs Logan Allen (Guardians) - 7-10, 4.42 ERA

The Rays will look to Ryan Pepiot (10-10) against the Guardians and Logan Allen (7-10). Pepiot's team is 9-18-0 against the spread in his starts this season. Pepiot's team has a record of 8-5 this season when he starts and they are the favorite on the moneyline. The Guardians have a 12-12-0 record against the spread in Allen's starts. The Guardians have a 6-9 record in Allen's 15 starts this season when they were the underdog on the moneyline.

Rays vs Guardians Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Rays win (63.7%)

Rays vs Guardians Moneyline

• Cleveland is a +136 underdog on the moneyline, while Tampa Bay is a -162 favorite at home.

Rays vs Guardians Spread

• The Guardians are at the Rays, and are +1.5 on the runline. The Guardians are +126 to cover the spread, and the Rays are -152.

Rays vs Guardians Over/Under

• An over/under of 8.5 has been set for Rays-Guardians on Sept. 4, with the over being -106 and the under -114.

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Rays vs Guardians Betting Trends

• The Rays have been victorious in 37, or 59.7%, of the 62 contests they have been chosen as favorites in this season.
• This year Tampa Bay has won six of 16 games when listed as at least -162 on the moneyline.
• The Rays and their opponents have hit the over in 58 of their 134 games with a total set by oddsmakers this season.
• The Rays have posted a record of 60-74-0 against the spread this season.
• The Guardians have been the moneyline underdog 78 total times this season. They've gone 33-45 in those games.
• Cleveland is 7-14 (winning only 33.3% of its games) when playing as a moneyline underdog of +136 or longer.
• The Guardians have played in 135 games with a set over/under, and have combined with their opponents to go over the total 61 times (61-68-6).
• The Guardians have covered 51.9% of their games this season, going 70-65-0 ATS.

Rays Player Leaders

• Junior Caminero has 138 hits, which is tops among Tampa Bay hitters this season, while batting .263 with 65 extra-base hits. He has an on-base percentage of .304 and a slugging percentage of .540.
• Among qualified hitters in MLB, his batting average ranks 66th, his on-base percentage ranks 126th, and he is ninth in slugging.
• Caminero hopes to build on a three-game hitting streak in this matchup. In his last five games he is batting .400 with three doubles, a home run, a walk and eight RBIs.
• Yandy Diaz has a slash line of .294/.353/.479 this season and a team-best OPS of .832.
• Among qualifying batters, he is 12th in batting average, 36th in on-base percentage and 37th in slugging percentage.
• Diaz takes a three-game streak with at least one hit into this one. During his last five outings he is batting .500 with two doubles, three walks and two RBIs.
• Brandon Lowe has 115 hits this season and has a slash line of .265/.319/.493.
• Lowe has logged a hit or more in seven games in a row. During his last 10 games he is batting .229 with two doubles, three home runs, five walks and 11 RBIs.
• Chandler Simpson is batting .294 with a .328 OBP and 22 RBI for Tampa Bay this season.
• Simpson heads into this matchup on a three-game hitting streak. During his last five outings he is hitting .273 with .

Guardians Player Leaders

• Jose Ramirez has put up a team-high OBP (.353), while pacing the Guardians in hits (140). He's batting .278 and slugging.
• Including all the qualifying hitters in MLB, his batting average ranks 29th, his on-base percentage is 36th, and he is 28th in slugging.
• Steven Kwan paces his team with a .382 slugging percentage. He has a batting average of .274 with an on-base percentage of .330.
• Including all qualified hitters, he ranks 37th in batting average, 78th in on-base percentage and 128th in slugging percentage.
• Kyle Manzardo has 14 doubles, two triples, 24 home runs and 42 walks while hitting .231.
• Angel Martinez is batting .226 with 21 doubles, a triple, 10 home runs and 17 walks.

Rays vs Guardians Head to Head

• 8/27/2025: 4-3 CLE (Favorite: Rays, Spread: -1.5, Total: 7, Favorite Moneyline: -148, Underdog Moneyline: +126)
• 8/26/2025: 3-0 CLE (Favorite: Guardians, Spread: -1.5, Total: 7.5, Favorite Moneyline: -120, Underdog Moneyline: +102)
• 8/25/2025: 9-0 TB (Favorite: Guardians, Spread: -1.5, Total: 7.5, Favorite Moneyline: -120, Underdog Moneyline: +102)
• 9/15/2024: 2-0 CLE (Favorite: Guardians, Spread: -1.5, Total: 8, Favorite Moneyline: -124, Underdog Moneyline: +106)
• 9/14/2024: 6-1 CLE (Favorite: Guardians, Spread: -1.5, Total: 8, Favorite Moneyline: -138, Underdog Moneyline: +118)
• 9/13/2024: 3-1 TB (Favorite: Guardians, Spread: -1.5, Total: 7.5, Favorite Moneyline: -184, Underdog Moneyline: +154)
• 9/12/2024: 5-2 TB (Favorite: Guardians, Spread: -1.5, Total: 7.5, Favorite Moneyline: -136, Underdog Moneyline: +116)
• 7/14/2024: 2-0 TB (Favorite: Rays, Spread: -1.5, Total: 7.5, Favorite Moneyline: -130, Underdog Moneyline: +110)
• 7/13/2024: 4-2 CLE (Favorite: Guardians, Spread: -1.5, Total: 7.5, Favorite Moneyline: -110, Underdog Moneyline: -106)
• 7/12/2024: 2-0 TB (Favorite: Rays, Spread: -1.5, Total: 7.5, Favorite Moneyline: -136, Underdog Moneyline: +116)

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