Rays vs Guardians Prediction, Odds, Moneyline, Spread & Over/Under for Aug. 27

Odds updated as of 8:20 p.m.

The MLB slate on Wednesday includes the Tampa Bay Rays taking on the Cleveland Guardians.

Before checking out the MLB betting lines on FanDuel Sportsbook, we've got you covered, in terms of the most important info regarding this matchup.

Rays vs Guardians Game Info

• Tampa Bay Rays (64-67) vs. Cleveland Guardians (64-66)
• Date: Wednesday, August 27, 2025
• Time: 1:10 p.m. ET
• Venue: Progressive Field -- Cleveland, Ohio
• Coverage: MLB Network, CLEG, and FDSSUN

Rays vs Guardians Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: TB: (-134) | CLE: (+114)
• Spread: TB: -1.5 (+128) | CLE: +1.5 (-154)
• Total: 7.5 -- Over: (-110) | Under: (-110)

Rays vs Guardians Probable Starting Pitchers

Probable Pitchers: Drew Rasmussen (Rays) - 10-5, 2.62 ERA vs Slade Cecconi (Guardians) - 5-6, 4.41 ERA

The Rays will look to Drew Rasmussen (10-5) versus the Guardians and Slade Cecconi (5-6). Rasmussen's team is 13-9-0 against the spread in his starts this season. Rasmussen's team is 8-6 this season when he starts and they are the moneyline favorite. The Guardians have a 10-6-0 record against the spread in Cecconi's starts. The Guardians have a 4-4 record in Cecconi's eight starts this season when they were the underdog on the moneyline.

Rays vs Guardians Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Rays win (59%)

Rays vs Guardians Moneyline

• The Rays vs Guardians moneyline has Tampa Bay as a -134 favorite, while Cleveland is a +114 underdog at home.

Rays vs Guardians Spread

• The Guardians are hosting the Rays, and are +1.5 on the runline. The Guardians are +128 to cover the spread, and the Rays are -154.

Rays vs Guardians Over/Under

• Rays versus Guardians, on Aug. 27, has an over/under of 7.5, with the over being -110 and the under -110.

Bet on Tampa Bay Rays vs. Cleveland Guardians on FanDuel today!

Rays vs Guardians Betting Trends

• The Rays have won in 34, or 58.6%, of the 58 contests they have been named as odds-on favorites in this year.
• This year Tampa Bay has won 17 of 31 games when listed as at least -134 on the moneyline.
• The Rays' games have gone over the total in 54 of their 126 opportunities.
• The Rays have an against the spread mark of 54-72-0 in 126 games with a line this season.
• The Guardians have won 29 of the 71 games they were listed as the moneyline underdog this season (40.8%).
• When it has played as a moneyline underdog with odds of +114 or longer, Cleveland has gone 15-20 (42.9%).
• The Guardians have played in 127 games with a set over/under, and have combined with their opponents to go over the total 58 times (58-65-4).
• The Guardians have put together a 65-62-0 record against the spread this season (covering 51.2% of the time).

Rays Player Leaders

• Junior Caminero has 128 hits, which is best among Tampa Bay hitters this season, while batting .261 with 61 extra-base hits. He has an on-base percentage of .303 and a slugging percentage of .544.
• Among qualifying hitters in the majors, he ranks 71st in batting average, 127th in on-base percentage, and sixth in slugging.
• Caminero hopes to build on a five-game hitting streak in this matchup. In his last five games he is hitting .381 with a double, four home runs, two walks and nine RBIs.
• Yandy Diaz has an OPS of .805, fueled by an OBP of .339 and a team-best slugging percentage of .466 this season. He's batting .280.
• He ranks 30th in batting average, 57th in on-base percentage and 47th in slugging among qualified batters.
• Brandon Lowe has collected 108 base hits, an OBP of .320 and a slugging percentage of .483 this season.
• Chandler Simpson has been key for Tampa Bay with 91 hits, an OBP of .340 plus a slugging percentage of .359.

Guardians Player Leaders

• Jose Ramirez has an on-base percentage of .360, a slugging percentage of .507, and has 137 hits, all club-highs for the Guardians (while batting .286).
• Including all the qualifying players in MLB, he ranks 22nd in batting average, 25th in on-base percentage and 16th in slugging percentage.
• Steven Kwan is hitting .271 with 22 doubles, a triple, 10 home runs and 43 walks. He's slugging .380 with an on-base percentage of .329.
• His batting average ranks 46th among all qualified players, his on-base percentage is 81st, and he is 130th in slugging.
• Kyle Manzardo is hitting .231 with 14 doubles, two triples, 21 home runs and 40 walks.
• Angel Martinez is hitting .228 with 21 doubles, a triple, 10 home runs and 15 walks.

Rays vs Guardians Head to Head

• 8/25/2025: 9-0 TB (Favorite: Guardians, Spread: -1.5, Total: 7.5, Favorite Moneyline: -120, Underdog Moneyline: +102)
• 9/15/2024: 2-0 CLE (Favorite: Guardians, Spread: -1.5, Total: 8, Favorite Moneyline: -124, Underdog Moneyline: +106)
• 9/14/2024: 6-1 CLE (Favorite: Guardians, Spread: -1.5, Total: 8, Favorite Moneyline: -138, Underdog Moneyline: +118)
• 9/13/2024: 3-1 TB (Favorite: Guardians, Spread: -1.5, Total: 7.5, Favorite Moneyline: -184, Underdog Moneyline: +154)
• 9/12/2024: 5-2 TB (Favorite: Guardians, Spread: -1.5, Total: 7.5, Favorite Moneyline: -136, Underdog Moneyline: +116)
• 7/14/2024: 2-0 TB (Favorite: Rays, Spread: -1.5, Total: 7.5, Favorite Moneyline: -130, Underdog Moneyline: +110)
• 7/13/2024: 4-2 CLE (Favorite: Guardians, Spread: -1.5, Total: 7.5, Favorite Moneyline: -110, Underdog Moneyline: -106)
• 7/12/2024: 2-0 TB (Favorite: Rays, Spread: -1.5, Total: 7.5, Favorite Moneyline: -136, Underdog Moneyline: +116)
• 9/3/2023: 6-2 TB (Favorite: Rays, Spread: -1.5, Total: 9.5, Favorite Moneyline: -148, Underdog Moneyline: +126)
• 9/2/2023: 7-6 CLE (Favorite: Rays, Spread: -1.5, Total: 8.5, Favorite Moneyline: -116, Underdog Moneyline: -102)

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