Rams vs Saints Week 16 NFL Odds, Predictions, Spread, Kickoff Time & Best Bets for December 21 Thursday Night Football

The Thursday slate in the NFL includes a matchup between the Los Angeles Rams and the New Orleans Saints.

Get the latest NFL odds ahead of this matchup on FanDuel Sportsbook.

Rams vs Saints Prediction & Pick

All NFL win probability predictions and picks are according to numberFire.
Prediction: Rams win (67.2%)

Rams vs Saints Point Spread

The Rams are 4.5-point favorites against the Saints. The Rams are -105 to cover the spread, while the Saints are -115 to cover as a 4.5-point underdog.

Rams vs Saints Over/Under

Rams versus Saints on December 21 has an over/under of 45.5 points, with the over -104 and the under -118.

Rams vs Saints Moneyline

The moneyline numbers for Rams vs. Saints reveal Los Angeles as the favorite (-220) and New Orleans as the underdog (+184) on the road.

Rams vs Saints Betting Trends

• Los Angeles has covered the spread seven times in 14 games.
• The Rams have covered every time (2-0) as a 4.5-point favorite or greater this season.
• This season, six of the Rams' 14 games have gone over the point total.
• The Saints have covered the spread four times in 14 games.
• This season, four of the Saints' 14 games have gone over the point total.

Rams vs Saints Odds & Spread

• All NFL odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: LAR: (-220) | NO: (+184)
• Spread: LAR: -4.5 (-105) | NO: +4.5 (-115)
• Total: 45.5 -- Over: (-104) | Under: (-118)

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