Purdue vs McNeese Basketball Prediction, Odds, Picks, Best Bets for NCAA Tournament Second Round

The No. 4 seed Purdue Boilermakers (23-11) take on the No. 12 seed McNeese Cowboys (28-6) with a Sweet 16 spot in the Midwest Region of the bracket on the line on Saturday at Amica Mutual Pavilion at 12:10 p.m. ET.

Before you place your bet on this game at FanDuel Sportsbook, here are the NCAA basketball odds and spreads you need to know.

Purdue vs. McNeese Game Info and Odds

• Game day: Saturday, March 22, 2025
• Game time: 12:10 p.m. ET
• TV channel: CBS
• Location: Providence, Rhode Island
• Arena: Amica Mutual Pavilion

Purdue vs. McNeese Picks and Prediction

All college basketball win probability predictions and picks are according to numberFire.
Prediction: Purdue win (53.4%)

Read these betting insights and trends before you bet on Saturday's Purdue-McNeese spread (Purdue -6.5) or over/under (141.5 points).

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Purdue vs. McNeese: ATS Betting Stats and Trends

• Purdue has won 18 games against the spread this season, while failing to cover 16 times.
• McNeese is 16-15-0 ATS this season.
• McNeese covers the spread when it is a 6.5-point underdog or more 100% of the time. That's more often than Purdue covers as a favorite of 6.5 or more (62.5%).
• The Boilermakers have done a better job covering the spread at home (10-6-0) than they have in road affairs (6-5-0).
• The Cowboys' winning percentage against the spread at home is .545 (6-5-0). Away, it is .500 (6-6-0).

Purdue vs. McNeese: Moneyline Betting Stats

• Purdue has come away with 21 wins in the 26 contests it has been listed as the moneyline favorite in this season.
• The Boilermakers have a mark of 15-1 in contests where oddsmakers favor them by -265 or better on the moneyline.
• McNeese has won 33.3% of the games this season it was the underdog on the moneyline (1-2).
• The Cowboys have a record of 1-2 when playing as a moneyline underdog with odds of +215 or longer (33.3%).
• The moneyline set for this matchup implies Purdue has a 72.6% chance of walking away with the win.

Purdue vs. McNeese Head-to-Head Comparison

• Purdue has a +236 scoring differential, topping opponents by 6.9 points per game. It is putting up 77.8 points per game to rank 78th in college basketball and is allowing 70.9 per contest to rank 145th in college basketball.
• Purdue's leading scorer, Trey Kaufman-Renn, ranks 14th in college basketball putting up 20.2 points per game.
• McNeese is outscoring opponents by 12.9 points per game, with a +438 scoring differential overall. It puts up 77 points per game (90th in college basketball) and allows 64.1 per contest (15th in college basketball).
• Javohn Garcia is 477th in the nation with a team-high 13.3 points per game.
• The Boilermakers are 302nd in the country at 29.9 rebounds per game. That's 1.6 more than the 28.3 their opponents average.
• Kaufman-Renn leads the team with 6.3 rebounds per game (258th in college basketball play).
• The Cowboys are 78th in college basketball at 33.6 rebounds per game. That's 4.1 more than the 29.5 their opponents average.
• Joe Charles' seven rebounds per game lead the Cowboys and rank 167th in the country.
• Purdue ranks 18th in college basketball by averaging 104.7 points per 100 possessions on offense, and defensively is 235th in college basketball, allowing 95.3 points per 100 possessions.
• The Cowboys rank 42nd in college basketball with 102.1 points scored per 100 possessions, and 12th defensively with 85 points conceded per 100 possessions.

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