Purdue vs Indiana College Basketball Prediction, Odds, Picks, Best Bets for Jan. 27

Big Ten play features the No. 12 Purdue Boilermakers (17-3, 7-2 Big Ten) on the road against the Indiana Hoosiers (13-7, 4-5 Big Ten) on Tuesday, January 27, 2026 at 9 p.m. ET.

Before you place your bet on this matchup at FanDuel Sportsbook, here are the NCAA basketball odds and spreads you need to know.

Purdue vs. Indiana Game Info and Odds

• Game day: Tuesday, January 27, 2026
• Game time: 9 p.m. ET
• TV channel: Peacock
• Location: Bloomington, Indiana
• Arena: Simon Skjodt Assembly Hall

Purdue vs. Indiana Picks and Prediction

All college basketball win probability predictions and picks are according to numberFire.
Prediction: Purdue win (57.8%)

Take a look at the betting insights and trends below before making a bet on Tuesday's Purdue-Indiana spread (Purdue -4.5) or over/under (150.5 points).

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Purdue vs. Indiana: ATS Betting Stats and Trends

• Purdue has compiled a 9-11-0 record against the spread this season.
• Indiana has compiled a 10-10-0 ATS record so far this year.
• Indiana covers the spread when it is a 4.5-point underdog or more 50% of the time. That's more often than Purdue covers as a favorite of 4.5 or more (38.9%).
• The Boilermakers have covered the spread in a lower percentage of their home games than away games. They have covered four times in 12 games when playing at home, and they've covered three times in five games when playing on the road.
• The Hoosiers' winning percentage against the spread, both home and away, is .500. They are 6-6-0 ATS on their home court and 3-3-0 on the road.
• Purdue has beaten the spread three times in nine conference games.
• Against the spread in Big Ten play, Indiana is 5-4-0 this season.

Purdue vs. Indiana: Moneyline Betting Stats

• Purdue has won in 13, or 81.2%, of the 16 contests it has been named as the moneyline favorite in this year.
• This season, the Boilermakers have come away with a win 12 times in 15 chances when named as a favorite of at least -210 or shorter on the moneyline.
• Indiana has lost all four of the games it has been the underdog on the moneyline this season.
• The Hoosiers have played as a moneyline underdog of +168 or longer in just two games this season, which they lost both.
• The moneyline set for this matchup implies Purdue has a 67.7% chance of coming away with a victory in the contest.

Purdue vs. Indiana Head-to-Head Comparison

• Purdue's +298 scoring differential (outscoring opponents by 14.9 points per game) is a result of scoring 84.0 points per game (49th in college basketball) while allowing 69.1 per outing (64th in college basketball).
• Braden Smith ranks 267th in the nation with a team-leading 15.2 points per game.
• Indiana is outscoring opponents by 11.8 points per game, with a +235 scoring differential overall. It puts up 81.2 points per game (90th in college basketball) and allows 69.4 per outing (72nd in college basketball).
• Lamar Wilkerson is 47th in the nation with a team-high 19.4 points per game.
• The Boilermakers rank 102nd in the country at 34.0 rebounds per game. That's 7.1 more than the 26.9 their opponents average.
• Trey Kaufman-Renn averages 8.6 rebounds per game (ranking 46th in college basketball) to lead the Boilermakers.
• The Hoosiers win the rebound battle by 2.1 boards on average. They collect 31.1 rebounds per game, 260th in college basketball, while their opponents pull down 29.0.
• Tucker DeVries leads the team with 5.0 rebounds per game (585th in college basketball).
• Purdue's 110.4 points per 100 possessions on offense rank eighth in college basketball, and the 90.8 points it allows per 100 possessions rank 109th in college basketball.
• The Hoosiers rank 25th in college basketball with 106.8 points scored per 100 possessions, and 119th defensively with 91.3 points conceded per 100 possessions.

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