Pirates vs Cardinals Prediction, Odds, Moneyline, Spread & Over/Under for Aug. 28

Odds updated as of 10:13 a.m.

On Friday in MLB, the Pittsburgh Pirates are playing the St. Louis Cardinals.

All the info you need to make smart bets on this game at FanDuel Sportsbook can be found below. Check out all of the latest MLB betting lines here.

Pirates vs Cardinals Game Info

• Pittsburgh Pirates (65-70) vs. St. Louis Cardinals (67-68)
• Date: Friday, August 28, 2026
• Time: 8:15 p.m. ET
• Venue: Busch Stadium -- St. Louis, Missouri
• Coverage: Cardinals.TV and SportsNet PT

Pirates vs Cardinals Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: PIT: (-110) | STL: (+100)
• Spread: PIT: -1.5 (+152) | STL: +1.5 (-184)
• Total: 7.5 -- Over: (-108) | Under: (-112)

Pirates vs Cardinals Probable Starting Pitchers

Probable Pitchers: Jared Jones (Pirates) - 2-5, 4.76 ERA vs Quinn Mathews (Cardinals) - 0-2, 6.43 ERA

The Pirates will call on Jared Jones (2-5) versus the Cardinals and Quinn Mathews (0-2). Jones' team is 7-8-0 against the spread this season in his starts. When Jones starts a game and his team is the favorite on the moneyline, they have a record of 2-3. The Cardinals did not cover any of Mathews' three starts with a set spread. The Cardinals were named the moneyline underdog for two Mathews starts this season -- they lost both.

Pirates vs Cardinals Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Pirates win (51.7%)

Pirates vs Cardinals Moneyline

• Looking at the moneyline for Cardinals-Pirates, St. Louis is the underdog at +100, and Pittsburgh is -110 playing on the road.

Pirates vs Cardinals Spread

• The Pirates are 1.5-run road favorites on the runline against the Cardinals. The Pirates are +152 to cover, and the Cardinals are -184.

Pirates vs Cardinals Over/Under

• A total of 7.5 runs has been set for the Pirates-Cardinals contest on Aug. 28, with the over available at -108 and the under at -112.

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Pirates vs Cardinals Betting Trends

• The Pirates have won in 38, or 55.9%, of the 68 contests they have been named as odds-on favorites in this year.
• This season Pittsburgh has come away with a win 38 times in 67 chances when named as a favorite of at least -110 on the moneyline.
• The Pirates and their opponents have hit the over in 72 of their 133 games with a total set by oddsmakers this season.
• The Pirates are 65-68-0 against the spread in their 133 games that had a posted line this season.
• The Cardinals have won 46.1% of the games this season they were the moneyline underdog (41-48).
• St. Louis is 35-35 (winning 50% of its games) when playing as a moneyline underdog of +100 or longer.
• The Cardinals have played in 131 games with an over/under set, and have combined with opponents to go over the total 57 times (57-67-7).
• The Cardinals have gone 70-61-0 against the spread this season.

Pirates Player Leaders

• Bryan Reynolds has 131 hits this season and a team-best OBP of .370. He has a .263 batting average and a slugging percentage of .425.
• Among qualified hitters in MLB, his batting average ranks 55th, his on-base percentage ranks 16th, and he is 66th in slugging.
• Reynolds will look for his fourth straight game with a hit in this matchup. During his last five outings he is hitting .250 with a double and two walks.
• Brandon Lowe leads Pittsburgh with 123 hits. He is batting .249 this season and has 54 extra-base hits. He's also slugging .470 with an on-base percentage of .316.
• Among all qualifying hitters, he ranks 81st in batting average, 95th in on-base percentage and 35th in slugging percentage.
• Nick Gonzales has an OPS of .758, fueled by an OBP of .365 and a team-best slugging percentage of .394 this season.
• Spencer Horwitz has 10 home runs, 38 RBI and a batting average of .254 this season.
• Horwitz has safely hit in four games in a row. In his last five games he is batting .227 with a walk.

Cardinals Player Leaders

• Alec Burleson has racked up a team-best .484 slugging percentage. He's batting .292 with an on-base percentage of .356.
• Including all the qualifying hitters in the big leagues, he is ninth in batting average, 38th in on-base percentage and 24th in slugging percentage.
• Burleson hopes to build on a 13-game hitting streak in this matchup. In his last 10 games he is batting .316 with a double, a walk and seven RBIs.
• Jordan Walker's 146 hits pace his team. He has a batting average of .286 while slugging .502 with an on-base percentage of .345.
• Including all qualified hitters, he ranks 16th in batting average, 50th in on-base percentage and 16th in slugging percentage.
• JJ Wetherholt is hitting .245 with 14 doubles, 17 home runs and 63 walks.
• Ivan Herrera has a .361 OBP to pace his team.

Pirates vs Cardinals Head to Head

• 5/21/2026: 6-2 PIT (Favorite: Pirates, Spread: -1.5, Total: 7, Favorite Moneyline: -122, Underdog Moneyline: +104)
• 5/20/2026: 7-0 PIT (Favorite: Cardinals, Spread: -1.5, Total: 7.5, Favorite Moneyline: -112, Underdog Moneyline: -104)
• 5/19/2026: 9-6 STL (Favorite: Cardinals, Spread: -1.5, Total: 8, Favorite Moneyline: -116, Underdog Moneyline: -102)
• 4/30/2026: 10-5 STL (Favorite: Pirates, Spread: -1.5, Total: 7, Favorite Moneyline: -245, Underdog Moneyline: +200)
• 4/29/2026: 5-4 STL (Favorite: Pirates, Spread: -1.5, Total: 8.5, Favorite Moneyline: -132, Underdog Moneyline: +112)
• 4/28/2026: 11-7 STL (Favorite: Pirates, Spread: -1.5, Total: 8.5, Favorite Moneyline: -162, Underdog Moneyline: +136)
• 4/27/2026: 4-2 STL (Favorite: Pirates, Spread: -1.5, Total: 8, Favorite Moneyline: -122, Underdog Moneyline: +104)
• 8/28/2025: 4-1 STL (Favorite: Cardinals, Spread: -1.5, Total: 8, Favorite Moneyline: -120, Underdog Moneyline: +102)
• 8/27/2025: 2-1 PIT (Favorite: Cardinals, Spread: -1.5, Total: 7.5, Favorite Moneyline: -174, Underdog Moneyline: +146)
• 8/26/2025: 8-3 PIT (Favorite: Cardinals, Spread: -1.5, Total: 8, Favorite Moneyline: -126, Underdog Moneyline: +108)

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