Pirates vs Brewers Prediction, Odds, Moneyline, Spread & Over/Under for May 23

Odds updated as of 6:12 a.m.

Friday's slate in the MLB includes a matchup between the Pittsburgh Pirates and the Milwaukee Brewers.

We've got you covered, in terms of the vital information about this matchup before you take a look at the MLB odds and spreads on FanDuel Sportsbook.

Pirates vs Brewers Game Info

• Pittsburgh Pirates (17-34) vs. Milwaukee Brewers (25-26)
• Date: Friday, May 23, 2025
• Time: 6:40 p.m. ET
• Venue: PNC Park -- Pittsburgh, Pennsylvania
• Coverage: SportsNet PT and FDSWI

Pirates vs Brewers Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: PIT: (-124) | MIL: (+106)
• Spread: PIT: -1.5 (+180) | MIL: +1.5 (-220)
• Total: 7 -- Over: (-110) | Under: (-110)

Pirates vs Brewers Probable Starting Pitchers

Probable Pitchers: Paul Skenes (Pirates) - 3-5, 2.44 ERA vs Freddy Peralta (Brewers) - 5-3, 2.59 ERA

The Pirates will call on Paul Skenes (3-5) versus the Brewers and Freddy Peralta (5-3). Skenes' team is 4-6-0 against the spread in his starts this season. Skenes' team has won 28.6% of his starts when they are favored on the moneyline (2-5). When Peralta starts, the Brewers have gone 6-4-0 against the spread. The Brewers were named the moneyline underdog for three Peralta starts this season -- they lost all of the games.

Pirates vs Brewers Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Pirates win (55.8%)

Pirates vs Brewers Moneyline

• Pittsburgh is the favorite, -124 on the moneyline, while Milwaukee is a +106 underdog on the road.

Pirates vs Brewers Spread

• The Brewers are at the Pirates, and are +1.5 on the runline. The Brewers are +180 to cover the spread, and the Pirates are -220.

Pirates vs Brewers Over/Under

• The Pirates-Brewers contest on May 23 has been given an over/under of 7 runs. The over is set at -110 and the under at -110.

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Pirates vs Brewers Betting Trends

• The Pirates have been chosen as favorites in 13 games this year and have walked away with the win five times (38.5%) in those games.
• This season Pittsburgh has been victorious three times in eight chances when named as a favorite of at least -124 on the moneyline.
• Contests with the Pirates have gone over the total set by bookmakers in 18 of 49 chances this season.
• In 49 games with a line this season, the Pirates have a mark of 20-29-0 against the spread.
• The Brewers have won five of the 23 games they were listed as the moneyline underdog this season (21.7%).
• When playing as a moneyline underdog with odds of +106 or longer, Milwaukee has a 2-12 record (winning only 14.3% of its games).
• In the 50 games bookmakers have set an over/under for the Brewers, they have combined with opponents to go over the total 20 times (20-29-1).
• The Brewers have collected a 27-23-0 record against the spread this season.

Pirates Player Leaders

• Oneil Cruz has 33 hits, which is best among Pittsburgh hitters this season, while batting .223 with 14 extra-base hits. He has an on-base percentage of .357 and a slugging percentage of .426.
• Among all qualified hitters in baseball, he ranks 131st in batting average, 47th in on-base percentage, and 74th in slugging.
• Cruz hopes to build on a two-game hitting streak in this matchup. During his last five outings he is batting .118 with a double, four walks and an RBI.
• Andrew McCutchen is batting .246 with seven doubles, three home runs and 23 walks, while slugging .359 with an on-base percentage of .357.
• His batting average is 94th among qualified players, his on-base percentage 47th, and his slugging percentage 131st.
• McCutchen has picked up a hit in two games in a row. During his last five outings he is batting .188 with four walks.
• Bryan Reynolds has collected 41 base hits, an OBP of .280 and a slugging percentage of .338 this season.
• Isiah Kiner-Falefa is batting .282 with a .338 OBP and eight RBI for Pittsburgh this season.
• Kiner-Falefa has hit safely in five straight games. In his last five games he is batting .333 with two doubles and a walk.

Brewers Player Leaders

• William Contreras is batting .255 with six doubles, four home runs and 31 walks. He's slugging .364 with an on-base percentage of .371.
• Including all qualifying hitters, he ranks 82nd in batting average, while his on-base percentage is 32nd and he is 126th in slugging.
• Jackson Chourio paces his team with a .421 slugging percentage. He has a batting average of .245 with an on-base percentage of .268.
• He ranks 96th in batting average, 149th in on-base percentage and 77th in slugging percentage in MLB.
• Brice Turang has four doubles, four home runs and 21 walks while batting .280.
• Sal Frelick has five doubles, three triples, three home runs and 17 walks while batting .280.

Pirates vs Brewers Head to Head

• 5/22/2025: 8-5 MIL (Favorite: Brewers, Spread: -1.5, Total: 9, Favorite Moneyline: -112, Underdog Moneyline: -104)
• 9/26/2024: 5-2 MIL (Favorite: Brewers, Spread: -1.5, Total: 7.5, Favorite Moneyline: -116, Underdog Moneyline: -102)
• 9/25/2024: 2-1 PIT (Favorite: Brewers, Spread: -1.5, Total: 7.5, Favorite Moneyline: -154, Underdog Moneyline: +130)
• 9/24/2024: 7-2 MIL (Favorite: Brewers, Spread: -1.5, Total: 7.5, Favorite Moneyline: -146, Underdog Moneyline: +124)
• 7/11/2024: 1-0 PIT (Favorite: Pirates, Spread: -1.5, Total: 7.5, Favorite Moneyline: -120, Underdog Moneyline: +102)
• 7/10/2024: 9-0 MIL (Favorite: Brewers, Spread: -1.5, Total: 8.5, Favorite Moneyline: -162, Underdog Moneyline: +136)
• 7/9/2024: 12-2 PIT (Favorite: Brewers, Spread: -1.5, Total: 8.5, Favorite Moneyline: -162, Underdog Moneyline: +136)
• 5/15/2024: 10-2 MIL (Favorite: Brewers, Spread: -1.5, Total: 8.5, Favorite Moneyline: -152, Underdog Moneyline: +128)
• 5/14/2024: 4-3 MIL (Favorite: Brewers, Spread: -1.5, Total: 8.5, Favorite Moneyline: -158, Underdog Moneyline: +134)
• 5/13/2024: 8-6 PIT (Favorite: Brewers, Spread: -1.5, Total: 8.5, Favorite Moneyline: -136, Underdog Moneyline: +116)

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