Phillies vs Astros Prediction, Odds, Moneyline, Spread & Over/Under for Sept. 10

Odds updated as of 8:12 p.m.

The MLB schedule on Thursday includes the Philadelphia Phillies facing the Houston Astros.

Before you do any MLB betting on this game at FanDuel Sportsbook, here's what you need to know.

Phillies vs Astros Game Info

• Philadelphia Phillies (81-64) vs. Houston Astros (74-71)
• Date: Thursday, September 10, 2026
• Time: 1:05 p.m. ET
• Venue: Citizens Bank Park -- Philadelphia, Pennsylvania
• Coverage: NBC 10 and SCHN

Phillies vs Astros Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: PHI: (-172) | HOU: (+144)
• Spread: PHI: -1.5 (+125) | HOU: +1.5 (-150)
• Total: 8.5 -- Over: (-112) | Under: (-108)

Phillies vs Astros Probable Starting Pitchers

Probable Pitchers: Zack Wheeler (Phillies) - 12-5, 3.23 ERA vs Cristian Javier (Astros) - 2-5, 5.98 ERA

The Phillies will give the ball to Zack Wheeler (12-5, 3.23 ERA), who is eyeing win No. 13 on the season, and the Astros will turn to Cristian Javier (2-5, 5.98 ERA). Wheeler's team is 13-8-0 against the spread this season in his starts. When Wheeler starts a game and his team is the favorite on the moneyline, they have a record of 13-3. The Astros have gone 3-6-0 ATS in Javier's nine starts that had a set spread. The Astros were named the moneyline underdog for two Javier starts this season -- they lost both.

Phillies vs Astros Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Phillies win (63.1%)

Phillies vs Astros Moneyline

• Houston is a +144 underdog on the moneyline, while Philadelphia is a -172 favorite at home.

Phillies vs Astros Spread

• The Phillies are hosting the Astros and are favored by 1.5 runs (+125 to cover) on the runline. Houston is -150 to cover.

Phillies vs Astros Over/Under

• A combined run total of 8.5 has been set for Phillies-Astros on Sept. 10, with the over at -112 and the under at -108.

Bet on Philadelphia Phillies vs. Houston Astros on FanDuel today!

Phillies vs Astros Betting Trends

• The Phillies have been victorious in 70, or 64.8%, of the 108 contests they have been chosen as favorites in this season.
• This year Philadelphia has won 32 of 39 games when listed as at least -172 on the moneyline.
• The Phillies and their opponents have hit the over in 66 of their 141 games with a total set by oddsmakers this season.
• The Phillies are 59-82-0 against the spread in their 141 games with a line set by sportsbooks this season.
• The Astros have been the moneyline underdog 75 total times this season. They've gone 39-36 in those games.
• When it has played as a moneyline underdog with odds of +144 or longer, Houston has gone 3-6 (33.3%).
• The Astros have combined with opponents to hit the over on the total 73 times this season for a 73-65-7 record against the over/under.
• The Astros have a 73-72-0 record against the spread this season.

Phillies Player Leaders

• Bryce Harper has 138 hits this season and a team-best OBP of .388. He has a .271 batting average and a slugging percentage of .497.
• Among all qualified hitters in the majors, he is 40th in batting average, fifth in on-base percentage, and 15th in slugging.
• Luis Arraez leads Philadelphia in slugging percentage (.428) thanks to 42 extra-base hits. He's batting .316 with an on-base percentage of .348.
• He is first in batting average, 43rd in on-base percentage and 65th in slugging among qualifying hitters.
• Kyle Schwarber leads Philadelphia in total hits (126) this season, and 61 of those have gone for extra bases.
• Schwarber has recorded a hit in four games in a row. During his last five outings he is batting .316 with three home runs, three walks and five RBIs.
• Bryson Stott is batting .252 with a .327 OBP and 61 RBI for Philadelphia this season.

Astros Player Leaders

• Yordan Alvarez has totaled 160 hits with a .428 on-base percentage and a .593 slugging percentage, all club-highs for the Astros. He's batting .311.
• Including all the qualifying hitters in MLB, his batting average ranks second, his on-base percentage is first, and he is first in slugging.
• Isaac Paredes has 25 doubles, a triple, 18 home runs and 63 walks while hitting .258. He's slugging .420 with an on-base percentage of .359.
• Including all qualified hitters, his batting average places him 64th, his on-base percentage is 31st, and he is 71st in slugging.
• Christian Walker is hitting .230 with 25 doubles, a triple, 25 home runs and 46 walks.
• Jose Altuve is batting .244 with 20 doubles, two triples, 15 home runs and 39 walks.

Phillies vs Astros Head to Head

• 9/8/2026: 6-5 HOU (Favorite: Phillies, Spread: -1.5, Total: 8.5, Favorite Moneyline: -136, Underdog Moneyline: +116)
• 6/26/2025: 2-1 HOU (Favorite: Astros, Spread: -1.5, Total: 7, Favorite Moneyline: -154, Underdog Moneyline: +130)
• 6/25/2025: 2-0 HOU (Favorite: Phillies, Spread: -1.5, Total: 7.5, Favorite Moneyline: -156, Underdog Moneyline: +132)
• 6/24/2025: 1-0 HOU (Favorite: Astros, Spread: -1.5, Total: 7.5, Favorite Moneyline: -154, Underdog Moneyline: +130)
• 8/28/2024: 10-0 HOU (Favorite: Astros, Spread: -1.5, Total: 10, Favorite Moneyline: -122, Underdog Moneyline: +104)
• 8/27/2024: 5-0 PHI (Favorite: Phillies, Spread: -1.5, Total: 9, Favorite Moneyline: -144, Underdog Moneyline: +122)
• 8/26/2024: 3-2 PHI (Favorite: Phillies, Spread: -1.5, Total: 8, Favorite Moneyline: -180, Underdog Moneyline: +152)
• 4/30/2023: 4-3 HOU (Favorite: Astros, Spread: -1.5, Total: 9, Favorite Moneyline: -168, Underdog Moneyline: +142)
• 4/29/2023: 6-1 PHI (Favorite: Astros, Spread: -1.5, Total: 7.5, Favorite Moneyline: -134, Underdog Moneyline: +114)
• 4/28/2023: 3-1 PHI (Favorite: Astros, Spread: -1.5, Total: 7.5, Favorite Moneyline: -146, Underdog Moneyline: +124)

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