Phillies vs Astros Prediction, Odds, Moneyline, Spread & Over/Under for Sept. 10

Odds updated as of 12:12 p.m.

The MLB's Thursday slate includes the Philadelphia Phillies taking on the Houston Astros.

Before you do any MLB betting on this game at FanDuel Sportsbook, here's everything you need to know.

Phillies vs Astros Game Info

• Philadelphia Phillies (82-64) vs. Houston Astros (74-72)
• Date: Thursday, September 10, 2026
• Time: 1:05 p.m. ET
• Venue: Citizens Bank Park -- Philadelphia, Pennsylvania
• Coverage: NBC 10 and SCHN

Phillies vs Astros Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: PHI: (-184) | HOU: (+154)
• Spread: PHI: -1.5 (+112) | HOU: +1.5 (-134)
• Total: 8.5 -- Over: (-110) | Under: (-110)

Phillies vs Astros Probable Starting Pitchers

Probable Pitchers: Zack Wheeler (Phillies) - 12-5, 3.23 ERA vs Cristian Javier (Astros) - 2-5, 5.98 ERA

This contest's pitching matchup is set, as the Phillies will send Zack Wheeler (12-5) to the mound, while Cristian Javier (2-5) will answer the bell for the Astros. Wheeler and his team are 13-8-0 ATS this season when he starts. Wheeler's team is 13-3 this season when he starts and they are the moneyline favorite. The Astros have gone 3-6-0 ATS in Javier's nine starts that had a set spread. The Astros were named the moneyline underdog for two Javier starts this season -- they lost both.

Phillies vs Astros Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Phillies win (63.2%)

Phillies vs Astros Moneyline

• Houston is the underdog, +154 on the moneyline, while Philadelphia is a -184 favorite at home.

Phillies vs Astros Spread

• The Phillies are hosting the Astros and are favored by 1.5 runs (+112 to cover) on the runline. Houston is -134 to cover.

Phillies vs Astros Over/Under

• Phillies versus Astros on Sept. 10 has an over/under of 8.5 runs, with the odds on the over -110 and the under set at -110.

Bet on Philadelphia Phillies vs. Houston Astros on FanDuel today!

Phillies vs Astros Betting Trends

• The Phillies have been victorious in 71, or 65.1%, of the 109 contests they have been chosen as favorites in this season.
• Philadelphia has a record of 26-4 when favored by -184 or more this year.
• The Phillies and their opponents have gone over in 67 of their 142 games with a total set by sportsbooks this season.
• The Phillies are 60-82-0 against the spread in their 142 games with a line set by sportsbooks this season.
• The Astros are 39-37 in games they were the underdog on the moneyline (winning 51.3% of those games).
• Houston is 1-5 (winning just 16.7% of its games) when it has played as a moneyline underdog of +154 or longer.
• The Astros have played in 146 games with an over/under set, and have combined with opponents to go over the total 74 times (74-65-7).
• The Astros have covered 50% of their games this season, going 73-73-0 against the spread.

Phillies Player Leaders

• Bryce Harper leads Philadelphia in OBP (.388) this season, fueled by 139 hits. He has a .271 batting average and a slugging percentage of .495.
• Among the qualifying hitters in baseball, his batting average ranks 40th, his on-base percentage ranks fifth, and he is 15th in slugging.
• Harper hopes to build on a two-game hitting streak in this matchup. In his last five games he is batting .222 with two walks and two RBIs.
• Luis Arraez has hit six homers this season while driving in 58 runs. He's batting .318 this season and slugging .431 with an on-base percentage of .350.
• Among all qualified hitters, he is first in batting average, 40th in on-base percentage and 59th in slugging percentage.
• Arraez heads into this game looking to extend his two-game hit streak. During his last five outings he is batting .353 with a double, a walk and three RBIs.
• Kyle Schwarber leads Philadelphia in total hits (127) this season, and 62 of those have gone for extra bases.
• Schwarber has recorded a hit in five games in a row. In his last five games he is hitting .350 with four home runs, three walks and nine RBIs.
• Trea Turner is batting .243 with a .295 OBP and 56 RBI for Philadelphia this season.
• Turner brings a six-game hitting streak into this game. In his last 10 outings he is batting .244 with five doubles, two home runs, three walks and five RBIs.

Astros Player Leaders

• Yordan Alvarez has accumulated a team-high OBP (.428) and slugging percentage (.593), and paces the Astros in hits (162, while batting .312).
• He is second in batting average, first in on-base percentage and first in slugging percentage among all qualified hitters in the majors.
• Isaac Paredes is hitting .260 with 25 doubles, a triple, 19 home runs and 63 walks. He's slugging .427 with an on-base percentage of .360.
• Including all qualifying hitters, he is 58th in batting average, 29th in on-base percentage and 65th in slugging percentage.
• Christian Walker is batting .228 with 25 doubles, a triple, 25 home runs and 46 walks.
• Jose Altuve is hitting .244 with 21 doubles, two triples, 15 home runs and 39 walks.

Phillies vs Astros Head to Head

• 9/9/2026: 11-7 PHI (Favorite: Phillies, Spread: -1.5, Total: 8.5, Favorite Moneyline: -154, Underdog Moneyline: +130)
• 9/8/2026: 6-5 HOU (Favorite: Phillies, Spread: -1.5, Total: 8.5, Favorite Moneyline: -136, Underdog Moneyline: +116)
• 6/26/2025: 2-1 HOU (Favorite: Astros, Spread: -1.5, Total: 7, Favorite Moneyline: -154, Underdog Moneyline: +130)
• 6/25/2025: 2-0 HOU (Favorite: Phillies, Spread: -1.5, Total: 7.5, Favorite Moneyline: -156, Underdog Moneyline: +132)
• 6/24/2025: 1-0 HOU (Favorite: Astros, Spread: -1.5, Total: 7.5, Favorite Moneyline: -154, Underdog Moneyline: +130)
• 8/28/2024: 10-0 HOU (Favorite: Astros, Spread: -1.5, Total: 10, Favorite Moneyline: -122, Underdog Moneyline: +104)
• 8/27/2024: 5-0 PHI (Favorite: Phillies, Spread: -1.5, Total: 9, Favorite Moneyline: -144, Underdog Moneyline: +122)
• 8/26/2024: 3-2 PHI (Favorite: Phillies, Spread: -1.5, Total: 8, Favorite Moneyline: -180, Underdog Moneyline: +152)
• 4/30/2023: 4-3 HOU (Favorite: Astros, Spread: -1.5, Total: 9, Favorite Moneyline: -168, Underdog Moneyline: +142)
• 4/29/2023: 6-1 PHI (Favorite: Astros, Spread: -1.5, Total: 7.5, Favorite Moneyline: -134, Underdog Moneyline: +114)

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