Penguins vs Flames NHL Prediction, Odds, Picks, Best Bets for Jan. 21

NHL action on Wednesday includes the Pittsburgh Penguins playing the Calgary Flames.

Before you place your bet on this matchup at FanDuel Sportsbook, here are the NHL moneyline insights you need to know.

Penguins vs Flames Game Info

• Pittsburgh Penguins (23-14-11) vs. Calgary Flames (21-23-5)
• Date: Wednesday, January 21, 2026
• Time: 9:30 p.m. ET
• Venue: Scotiabank Saddledome -- Calgary, Alberta
• Coverage: ESPN+

Penguins vs Flames Odds

All NHL odds, betting lines and prop bets are available on FanDuel Sportsbook.

Penguins vs Flames Prediction & Pick

All NHL win probability predictions and picks are according to numberFire.

• Prediction: Penguins win (66.9%)

Penguins vs Flames Puck Line

• The Penguins are favored by 1.5 goals (+198 to cover). Calgary, the underdog, is -250.

Penguins vs Flames Over/Under

• An over/under of 5.5 has been set for Penguins-Flames on Jan. 21, with the over being -130 and the under +106.

Penguins vs Flames Moneyline

• Looking at the moneyline for Flames-Penguins, Calgary is the underdog at -102, and Pittsburgh is -118 playing on the road.

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