Pelicans vs. Cavaliers Prediction, Odds, Picks, Best Bets for March 21

Pelicans vs. Cavaliers Game Info

• Date: Saturday, March 21, 2026
• Time: 7 p.m. ET
• Venue: Smoothie King Center -- New Orleans, Louisiana
• Coverage: FDSOH, Gulf Coast Sports, and Pelicans+

The New Orleans Pelicans (25-46) host the Cleveland Cavaliers (43-27) after winning seven home games in a row. The Cavaliers are favored by 5 points in the contest, which begins at 7 p.m. ET on Saturday, March 21, 2026. The matchup has an over/under of 233.5 points.

Pelicans vs. Cavaliers Odds & Spread

All NBA betting lines, odds and prop bets are from FanDuel Sportsbook.

Pelicans vs. Cavaliers Prediction & Pick

All NBA win probability predictions and picks are according to numberFire.
Prediction: Cavaliers win (73.3%)

Pelicans vs. Cavaliers Betting Trends

• The Cavaliers have compiled a 29-40-1 record against the spread this season.
• The Pelicans have played 71 games, with 41 wins against the spread.
• Cavaliers games have finished with a final combined score above the over/under 34 times out of 71 chances this season.
• Pelicans games this year have hit the over 49.3% of the time (35 out of 71 games with a set point total).
• At home, Cleveland has a worse record against the spread (14-20-1) compared to its ATS record in road games (15-20-0).
• The Cavaliers have eclipsed the over/under in 13 of 35 home games (37.1%). They've done better on the road, topping the total in 21 of 35 matchups (60%).
• New Orleans' winning percentage against the spread at home is .649 (24-13-0). On the road, it is .500 (17-15-1).
• Pelicans games have finished above the over/under more frequently at home (19 times out of 37) than away (16 of 34) this year.

Cavaliers Leaders

• Donovan Mitchell's numbers on the season are 28 points, 4.5 rebounds and 5.9 assists per contest, shooting 47.9% from the floor and 36.4% from beyond the arc, with an average of 3.3 made treys (sixth in league).
• James Harden is averaging 24.2 points, 8 assists and 4.9 rebounds.
• Evan Mobley averages 18.3 points, 8.9 rebounds and 3.6 assists.
• Jaylon Tyson is averaging 13.1 points, 5.1 rebounds and 2.2 assists. At the other end, he averages 0.8 steals and 0.4 blocked shots.
• Dennis Schroder is averaging 11.4 points, 5 assists and 2.7 boards.

Pelicans Leaders

• Trey Murphy III averages 22 points for the Pelicans, plus 5.7 boards and 3.9 assists.
• Saddiq Bey's numbers on the season are 17.4 points, 5.7 boards and 2.6 assists per contest. He is sinking 45% of his shots from the floor and 34.8% from 3-point range, with an average of 2 treys.
• Per game, Derik Queen gives the Pelicans 11.5 points, 6.9 rebounds and 3.8 assists, plus 0.9 steals and 0.9 blocks.
• The Pelicans get 21.3 points per game from Zion Williamson, plus 5.8 boards and 3.3 assists.
• Jeremiah Fears' numbers on the season are 13 points, 3.6 boards and 3.2 assists per game. He is making 42.8% of his shots from the field and 33.8% from beyond the arc, with an average of 1.1 treys.

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