Duke vs TCU College Basketball Prediction, Odds, Picks, Best Bets for NCAA Tournament Second Round

The No. 1 seed Duke Blue Devils (33-2) take on the No. 9 seed TCU Horned Frogs (23-11) with a Sweet 16 spot in the East Region of the bracket up for grabs on Saturday at Bon Secours Wellness Arena at 5:15 p.m. ET.

Before you place your bet on this matchup at FanDuel Sportsbook, here are the NCAA basketball odds and spreads you need to know.

Duke vs. TCU Game Info and Odds

• Game day: Saturday, March 21, 2026
• Game time: 5:15 p.m. ET
• TV channel: CBS
• Location: Greenville, South Carolina
• Arena: Bon Secours Wellness Arena

Duke vs. TCU Picks and Prediction

All college basketball win probability predictions and picks are according to numberFire.
Prediction: Duke win (77.6%)

Take a look at some betting trends for Duke (-11.5) versus TCU on Saturday. The over/under is set at 140.5 points for this game.

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Duke vs. TCU: ATS Betting Stats and Trends

• Duke is 18-17-0 ATS this season.
• TCU has covered 20 times in 34 matchups with a spread this season.
• TCU covers the spread when it is an 11.5-point underdog or more 100% of the time. That's more often than Duke covers as a favorite of 11.5 or more (38.1%).
• The Blue Devils have a worse record against the spread when playing at home (6-9-0) than they do in away games (8-3-0).
• The Horned Frogs' winning percentage against the spread at home is .474 (9-10-0). Away, it is .667 (6-3-0).

Duke vs. TCU: Moneyline Betting Stats

• Duke has won in 26, or 92.9%, of the 28 contests it has been named as the moneyline favorite in this year.
• The Blue Devils have not lost in 15 games this year when favored by -800 or better on the moneyline.
• TCU has won six of the 12 games it was the moneyline underdog this season (50%).
• The Horned Frogs have played as a moneyline underdog of +540 or longer in only two games this season, which they split 1-1.
• The moneyline set for this matchup implies Duke has a 88.9% chance of walking away with the win.

Duke vs. TCU Head-to-Head Comparison

• Duke was the 11th-best squad in the nation in points scored (83.2 per game) and seventh-best in points conceded (62.8) last season.
• Duke was the 24th-best team in college basketball in rebounds per game (35.6) and 12th-best in rebounds conceded (27.3) last year.
• At 16.9 assists per game, Duke was 17th-best in the nation last season.
• Last year, Duke was ninth-best in college basketball in turnovers committed (8.9 per game) and ranked 265th in turnovers forced (10.4).
• Offensively, TCU put up 67.6 points per game (326th-ranked in college basketball) last year. It ceded 68.7 points per contest at the other end of the court (74th-ranked).
• TCU pulled down 31.2 rebounds per game (221st-ranked in college basketball). It ceded 30.9 rebounds per contest (164th-ranked).
• TCU delivered 12.2 assists per game, which ranked them 279th in college basketball.
• Last year TCU committed 10.9 turnovers per game (150th-ranked in college basketball) and forced 12.1 turnovers per contest (100th-ranked).

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