Padres vs Reds Prediction, Odds, Moneyline, Spread & Over/Under for June 27

Odds updated as of 4:12 a.m.

The San Diego Padres are among the MLB teams in action on Friday, versus the Cincinnati Reds.

Here's what you need to know before checking out today's MLB odds and spreads on FanDuel Sportsbook.

Padres vs Reds Game Info

• San Diego Padres (44-36) vs. Cincinnati Reds (42-39)
• Date: Friday, June 27, 2025
• Time: 7:10 p.m. ET
• Venue: Great American Ball Park -- Cincinnati, Ohio
• Coverage: FDSOH and SDPA

Padres vs Reds Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: SD: (-138) | CIN: (+118)
• Spread: SD: -1.5 (+116) | CIN: +1.5 (-140)
• Total: 9 -- Over: (-122) | Under: (-100)

Padres vs Reds Probable Starting Pitchers

Probable Pitchers: Dylan Cease (Padres) - 3-6, 4.43 ERA vs Nick Martínez (Reds) - 4-8, 4.40 ERA

The probable pitchers are Dylan Cease (3-6) for the Padres and Nick Martinez (4-8) for the Reds. Cease and his team are 8-8-0 ATS this season when he starts. Cease's team has a record of 7-3 this season when he starts and they are the favorite on the moneyline. The Reds have gone 5-10-0 ATS in Martínez's 15 starts that had a set spread. The Reds have been the underdog on the moneyline in nine of Martínez's starts this season, and they went 2-7 in those matchups.

Padres vs Reds Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Padres win (57.2%)

Padres vs Reds Moneyline

• The Padres vs Reds moneyline has San Diego as a -138 favorite, while Cincinnati is a +118 underdog at home.

Padres vs Reds Spread

• The Reds are hosting the Padres, and are +1.5 on the runline. The Reds are +116 to cover the spread, and the Padres are -140.

Padres vs Reds Over/Under

• Padres versus Reds on June 27 has an over/under of 9 runs, with the odds on the over -122 and the under set at -100.

Bet on San Diego Padres vs. Cincinnati Reds on FanDuel today!

Padres vs Reds Betting Trends

• The Padres have been victorious in 25, or 62.5%, of the 40 contests they have been chosen as favorites in this season.
• This year San Diego has won 19 of 30 games when listed as at least -138 on the moneyline.
• The Padres and their opponents have hit the over in 33 of their 79 games with a total set by oddsmakers this season.
• The Padres are 42-37-0 against the spread in their 79 games that had a posted line this season.
• The Reds have been the underdog on the moneyline 45 total times this season. They've finished 23-22 in those games.
• Cincinnati has gone 8-12 when playing as a moneyline underdog with odds of +118 or longer (40%).
• The Reds have combined with opponents to hit the over on the total 34 times this season for a 34-41-2 record against the over/under.
• The Reds have covered 53.2% of their games this season, going 41-36-0 ATS.

Padres Player Leaders

• Manny Machado has 91 hits and an OBP of .360 to go with a slugging percentage of .492. All three of those stats lead San Diego hitters this season. He has a .298 batting average, as well.
• Among the qualified batters in baseball, his batting average ranks 16th, his on-base percentage ranks 32nd, and he is 26th in slugging.
• Fernando Tatis Jr. has 11 doubles, a triple, 15 home runs and 38 walks. He's batting .261 and slugging .455 with an on-base percentage of .351.
• Among all qualified hitters, he ranks 71st in batting average, 47th in on-base percentage and 54th in slugging percentage.
• Luis Arraez is batting .288 with a .397 slugging percentage and 30 RBI this year.
• Arraez brings a 12-game hitting streak into this game. In his last 10 games he is hitting .372 with a triple and four RBIs.
• Gavin Sheets has 12 home runs, 46 RBI and a batting average of .263 this season.

Reds Player Leaders

• Elly De La Cruz has racked up a team-high slugging percentage (.511) and paces the Reds in hits (86). He's batting .277 and with an on-base percentage of .351.
• Including all the qualified players in MLB, he ranks 44th in batting average, 47th in on-base percentage and 18th in slugging percentage.
• De La Cruz brings a six-game hitting streak into this game. In his last 10 games he is batting .341 with a double, two triples, three home runs, two walks and eight RBIs.
• TJ Friedl has a .372 OBP to lead his team. He has a batting average of .287 while slugging .426.
• Including all qualified hitters, he is 27th in batting average, 22nd in on-base percentage and 78th in slugging percentage.
• Gavin Lux has 14 doubles, a triple, four home runs and 32 walks while batting .266.
• Spencer Steer is batting .243 with 13 doubles, a triple, six home runs and 20 walks.

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