Padres vs Pirates Prediction, Odds, Moneyline, Spread & Over/Under for May 3

Odds updated as of 11:11 a.m.

The San Diego Padres will face the Pittsburgh Pirates in MLB action on Saturday.

Before checking out the MLB betting lines on FanDuel Sportsbook, we've got you covered, in terms of the most important information about this game.

Padres vs Pirates Game Info

• San Diego Padres (20-11) vs. Pittsburgh Pirates (12-21)
• Date: Saturday, May 3, 2025
• Time: 4:05 p.m. ET
• Venue: PNC Park -- Pittsburgh, Pennsylvania
• Coverage: SportsNet PT and SDPA

Padres vs Pirates Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: SD: (-110) | PIT: (-106)
• Spread: SD: -1.5 (+146) | PIT: +1.5 (-176)
• Total: 9 -- Over: (-120) | Under: (-102)

Padres vs Pirates Probable Starting Pitchers

Probable Pitchers: Randy Vasquez (Padres) - 1-3, 4.28 ERA vs Bailey Falter (Pirates) - 1-3, 5.93 ERA

The Padres will look to Randy Vasquez (1-3) against the Pirates and Bailey Falter (1-3). Vasquez and his team have a record of 3-3-0 against the spread when he starts. This will be Vasquez's first start this season with his team as the moneyline favorite. When Falter starts, the Pirates are 2-4-0 against the spread. The Pirates have a 1-3 record in Falter's four starts this season when they were the moneyline underdog.

Padres vs Pirates Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Padres win (59.9%)

Padres vs Pirates Moneyline

• Looking at the moneyline for Padres-Pirates, San Diego is the favorite at -110, and Pittsburgh is -106 playing at home.

Padres vs Pirates Spread

• The Pirates are +1.5 on the spread (-176 to cover), and San Diego is +146 to cover the runline.

Padres vs Pirates Over/Under

• An over/under of 9 has been set for Padres-Pirates on May 3, with the over being -120 and the under -102.

Bet on San Diego Padres vs. Pittsburgh Pirates on FanDuel today!

Padres vs Pirates Betting Trends

• The Padres have been favorites in 16 games this season and have come away with the win 12 times (75%) in those contests.
• San Diego has a record of 12-4 in contests when oddsmakers favor them by -110 or more on the moneyline.
• The Padres' games have gone over the total in 13 of their 31 opportunities.
• In 31 games with a line this season, the Padres have a mark of 18-13-0 against the spread.
• The Pirates have won seven of the 21 games they were the underdog on the moneyline this season (33.3%).
• When playing as a moneyline underdog with odds of -106 or longer, Pittsburgh has a 6-14 record (winning only 30% of its games).
• The Pirates have had an over/under set by bookmakers 33 times, and have combined with opponents to go over the total in 16 of those games (16-16-1).
• The Pirates have covered only 36.4% of their games this season, going 12-21-0 ATS.

Padres Player Leaders

• Fernando Tatis Jr. leads San Diego in OBP (.419), slugging percentage (.602) and total hits (39) this season. He has a .345 batting average.
• Among qualifying hitters, he ranks third in batting average, his on-base percentage ranks fifth, and he is sixth in slugging.
• Manny Machado is batting .278 with 10 doubles, two home runs and 11 walks, while slugging .417 with an on-base percentage of .339.
• Among all qualifying hitters, he is 41st in batting average, 64th in on-base percentage and 74th in slugging percentage.
• Machado has picked up a hit in three straight games. In his last five games he is batting .263 with a double, a walk and three RBI.
• Luis Arraez has collected 31 base hits, an OBP of .346 and a slugging percentage of .465 this season.
• Arraez brings a three-game hitting streak into this game. During his last five outings he is batting .429 with a double, a triple, two walks and five RBI.
• Xander Bogaerts is batting .243 with a .333 OBP and eight RBI for San Diego this season.

Pirates Player Leaders

• Oneil Cruz has accumulated an on-base percentage of .364 and has 26 hits, both team-best numbers for the Pirates. He's batting .245 and slugging .519.
• Including all qualified hitters in the majors, he is 85th in batting average, 38th in on-base percentage and 23rd in slugging percentage.
• Andrew McCutchen is batting .264 with six doubles, three home runs and 12 walks. He's slugging .429 with an on-base percentage of .356.
• He is 65th in batting average, 47th in on-base percentage and 65th in slugging percentage in the big leagues.
• Bryan Reynolds has a slugging percentage of .377, a team-high for the Pirates.
• Enmanuel Valdez has three doubles, two triples, two home runs and 11 walks while hitting .216.

Padres vs Pirates Head to Head

• 5/2/2025: 9-4 SD (Favorite: Padres, Spread: -1.5, Total: 8, Favorite Moneyline: -134, Underdog Moneyline: +114)
• 8/14/2024: 8-2 SD (Favorite: Padres, Spread: -1.5, Total: 8.5, Favorite Moneyline: -142, Underdog Moneyline: +120)
• 8/13/2024: 3-0 SD (Favorite: Padres, Spread: -1.5, Total: 7.5, Favorite Moneyline: -250, Underdog Moneyline: +205)
• 8/12/2024: 2-1 SD (Favorite: Padres, Spread: -1.5, Total: 8.5, Favorite Moneyline: -200, Underdog Moneyline: +168)
• 8/8/2024: 7-6 SD (Favorite: Pirates, Spread: -1.5, Total: 8.5, Favorite Moneyline: -110, Underdog Moneyline: -106)
• 8/7/2024: 9-8 SD (Favorite: Padres, Spread: -1.5, Total: 7.5, Favorite Moneyline: -158, Underdog Moneyline: +134)
• 8/6/2024: 6-0 SD (Favorite: Padres, Spread: -1.5, Total: 7.5, Favorite Moneyline: -164, Underdog Moneyline: +138)
• 7/26/2023: 3-2 PIT (Favorite: Padres, Spread: -1.5, Total: 8.5, Favorite Moneyline: -188, Underdog Moneyline: +158)
• 7/25/2023: 5-1 SD (Favorite: Padres, Spread: -1.5, Total: 8.5, Favorite Moneyline: -290, Underdog Moneyline: +235)
• 7/24/2023: 8-4 PIT (Favorite: Padres, Spread: -1.5, Total: 8.5, Favorite Moneyline: -275, Underdog Moneyline: +225)

Sign up for FanDuel Sportsbook and FanDuel Daily Fantasy today!