Padres vs Orioles Prediction, Odds, Moneyline, Spread & Over/Under for Sept. 2

Odds updated as of 2:11 p.m.

The MLB's Tuesday schedule includes the San Diego Padres facing the Baltimore Orioles.

Before you do any MLB betting on this game at FanDuel Sportsbook, here's what you need to know.

Padres vs Orioles Game Info

• San Diego Padres (76-62) vs. Baltimore Orioles (62-76)
• Date: Tuesday, September 2, 2025
• Time: 9:40 p.m. ET
• Venue: PETCO Park -- San Diego, California
• Coverage: SDPA and MASN2

Padres vs Orioles Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: SD: (-172) | BAL: (+144)
• Spread: SD: -1.5 (+126) | BAL: +1.5 (-152)
• Total: 8.5 -- Over: (-100) | Under: (-122)

Padres vs Orioles Probable Starting Pitchers

Probable Pitchers: Yu Darvish (Padres) - 3-4, 5.66 ERA vs Tyler Wells (Orioles) - 0-0, 0.00 ERA

The probable pitchers are Yu Darvish (3-4) for the Padres and Tyler Wells for the Orioles. Darvish and his team have a record of 7-2-0 against the spread when he starts. Darvish's team has a record of 2-1 this season when he starts and they are the favorite on the moneyline. Last season (in three games pitched with a spread) Wells and his team failed to cover the spread each time. Wells' team was the underdog on the moneyline just one time in a game he pitched a season ago, and lost.

Padres vs Orioles Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Padres win (61.5%)

Padres vs Orioles Moneyline

• The Padres vs Orioles moneyline has San Diego as a -172 favorite, while Baltimore is a +144 underdog on the road.

Padres vs Orioles Spread

• The Orioles are +1.5 on the run line against the Padres. The Orioles are -152 to cover, and the Padres are +126.

Padres vs Orioles Over/Under

• The over/under for Padres-Orioles on Sept. 2 is 8.5. The over is -100, and the under is -122.

Bet on San Diego Padres vs. Baltimore Orioles on FanDuel today!

Padres vs Orioles Betting Trends

• The Padres have come away with 43 wins in the 70 contests they have been listed as the favorites in this season.
• San Diego has a record of 13-6 when favored by -172 or more this year.
• The Padres' games have gone over the total in 60 of their 136 opportunities.
• The Padres are 75-61-0 against the spread in their 136 games that had a posted line this season.
• The Orioles have been the underdog on the moneyline 75 total times this season. They've finished 33-42 in those games.
• When it has played as a moneyline underdog with odds of +144 or longer, Baltimore has a 5-8 record (winning just 38.5% of its games).
• In the 135 games oddsmakers have set an over/under for the Orioles, they have combined with opponents to go over the total 59 times (59-72-4).
• The Orioles are 64-71-0 ATS this season.

Padres Player Leaders

• Fernando Tatis Jr. is hitting .264 with 27 doubles, two triples, 18 home runs and 81 walks. He has an on-base percentage of .370 and a slugging percentage of .430.
• Among qualified batters in baseball, he ranks 60th in batting average, 14th in on-base percentage, and 78th in slugging.
• Manny Machado has 151 hits, which is best among San Diego batters this season. He's batting .284 with 53 extra-base hits. He's also slugging .462 with an on-base percentage of .346.
• Among all qualifying players, he ranks 22nd in batting average, 45th in on-base percentage and 50th in slugging percentage.
• Luis Arraez has hit six homers with a team-high .388 SLG this season.
• Arraez has logged a hit or more in four straight games. During his last five outings he is hitting .353 with a walk and two RBIs.
• Ramon Laureano has been key for San Diego with 108 hits, an OBP of .354 plus a slugging percentage of .541.
• Laureano brings a three-game hitting streak into this game. During his last five outings he is batting .190 with a home run and four RBIs.

Orioles Player Leaders

• Gunnar Henderson has racked up an on-base percentage of .349, a slugging percentage of .457, and has 138 hits, all club-highs for the Orioles (while batting .279).
• Including all qualified hitters in the big leagues, his batting average puts him 27th, his on-base percentage ranks 42nd, and he is 56th in slugging.
• Henderson hopes to build on a four-game hitting streak in this matchup. During his last five outings he is hitting .300 with a walk and two RBIs.
• Jackson Holliday has 20 doubles, three triples, 15 home runs and 44 walks while hitting .245. He's slugging .384 with an on-base percentage of .312.
• He ranks 109th in batting average, 112th in on-base percentage and 124th in slugging percentage in the majors.
• Ryan Mountcastle is hitting .264 with 17 doubles, five home runs and 12 walks.
• Colton Cowser has 12 doubles, 12 home runs and 17 walks while batting .210.

Padres vs Orioles Head to Head

• 9/1/2025: 4-3 BAL (Favorite: Padres, Spread: -1.5, Total: 7.5, Favorite Moneyline: -168, Underdog Moneyline: +142)
• 7/28/2024: 8-6 BAL (Favorite: Orioles, Spread: -1.5, Total: 9.5, Favorite Moneyline: -138, Underdog Moneyline: +118)
• 7/27/2024: 9-4 SD (Favorite: Padres, Spread: -1.5, Total: 8.5, Favorite Moneyline: -112, Underdog Moneyline: -104)
• 7/26/2024: 6-4 SD (Favorite: Orioles, Spread: -1.5, Total: 9, Favorite Moneyline: -198, Underdog Moneyline: +166)
• 8/16/2023: 5-2 SD (Favorite: Padres, Spread: -1.5, Total: 8, Favorite Moneyline: -184, Underdog Moneyline: +154)
• 8/15/2023: 10-3 SD (Favorite: Padres, Spread: -1.5, Total: 8.5, Favorite Moneyline: -118, Underdog Moneyline: -100)
• 8/14/2023: 4-1 BAL (Favorite: Padres, Spread: -1.5, Total: 8, Favorite Moneyline: -146, Underdog Moneyline: +124)

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