Padres vs Nationals Prediction, Odds, Moneyline, Spread & Over/Under for July 18

Odds updated as of 4:12 a.m.

The MLB's Friday slate includes the San Diego Padres taking on the Washington Nationals.

Before checking out the MLB betting lines on FanDuel Sportsbook, we've got you covered, in terms of the vital information about this matchup.

Padres vs Nationals Game Info

• San Diego Padres (52-44) vs. Washington Nationals (38-58)
• Date: Friday, July 18, 2025
• Time: 6:45 p.m. ET
• Venue: Nationals Park -- Washington, District of Columbia
• Coverage: MASN and SDPA

Padres vs Nationals Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: SD: (-156) | WSH: (+132)
• Spread: SD: -1.5 (+106) | WSH: +1.5 (-128)
• Total: 8.5 -- Over: (-114) | Under: (-106)

Padres vs Nationals Probable Starting Pitchers

Probable Pitchers: Dylan Cease (Padres) - 3-9, 4.88 ERA vs Mike Soroka (Nationals) - 3-7, 5.35 ERA

The Padres will call on Dylan Cease (3-9) versus the Nationals and Mike Soroka (3-7). Cease and his team have a record of 8-11-0 against the spread when he starts. Cease's team is 7-5 this season when he starts and they are the moneyline favorite. The Nationals have gone 5-8-0 against the spread when Soroka starts. The Nationals have been the underdog on the moneyline in 12 of Soroka's starts this season, and they went 3-9 in those games.

Padres vs Nationals Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Padres win (57.3%)

Padres vs Nationals Moneyline

• Looking at the moneyline for Padres-Nationals, San Diego is the favorite at -156, and Washington is +132 playing at home.

Padres vs Nationals Spread

• The Nationals are +1.5 on the spread (-128 to cover), and San Diego is +106 to cover the runline.

Padres vs Nationals Over/Under

• The Padres-Nationals game on July 18 has been given an over/under of 8.5 runs. The over is set at -114 and the under at -106.

Bet on San Diego Padres vs. Washington Nationals on FanDuel today!

Padres vs Nationals Betting Trends

• The Padres have been favorites in 47 games this season and have come away with the win 28 times (59.6%) in those contests.
• This season San Diego has been victorious 14 times in 23 chances when named as a favorite of at least -156 on the moneyline.
• Contests with the Padres have gone over the total set by sportsbooks in 39 of 95 chances this season.
• The Padres are 51-44-0 against the spread in their 95 games that had a posted line this season.
• The Nationals have been the moneyline underdog 73 total times this season. They've finished 33-40 in those games.
• Washington has a 16-23 record (winning 41% of its games) when playing as a moneyline underdog of +132 or longer.
• In the 91 games oddsmakers have set an over/under for the Nationals, they have combined with opponents to go over the total 51 times (51-38-2).
• The Nationals are 47-44-0 ATS this season.

Padres Player Leaders

• Fernando Tatis Jr. leads San Diego with an OBP of .366 this season while batting .269 with 51 walks and 65 runs scored. He has a slugging percentage of .451.
• Among qualified batters in the majors, his batting average ranks 60th, his on-base percentage ranks 27th, and he is 62nd in slugging.
• Tatis hopes to build on a six-game hitting streak in this matchup. During his last 10 games he is hitting .343 with two doubles, a triple, a home run, 10 walks and four RBIs.
• Manny Machado leads San Diego in slugging percentage (.490) and total hits (107) this season. He's batting .292 with an on-base percentage of .350.
• Among qualified hitters, his batting average ranks him 17th, his on-base percentage 49th, and his slugging percentage 27th.
• Luis Arraez has 102 hits this season and has a slash line of .279/.314/.389.
• Gavin Sheets has been key for San Diego with 84 hits, an OBP of .324 plus a slugging percentage of .451.

Nationals Player Leaders

• James Wood has totaled 99 hits with a .381 on-base percentage and a .534 slugging percentage, all club-highs for the Nationals. He's batting .278.
• Including all the qualified players in MLB, his batting average ranks 45th, his on-base percentage ranks 12th, and he is 14th in slugging.
• C.J. Abrams is hitting .287 with 20 doubles, four triples, 12 home runs and 24 walks. He's slugging .483 with an on-base percentage of .353.
• Including all qualifying players, his batting average puts him 22nd, his on-base percentage ranks 44th, and he is 32nd in slugging.
• Luis Garcia is batting .259 with 20 doubles, seven home runs and 18 walks.
• Nathaniel Lowe is batting .227 with 14 doubles, two triples, 14 home runs and 34 walks.

Padres vs Nationals Head to Head

• 6/25/2025: 1-0 SD (Favorite: Padres, Spread: -1.5, Total: 7, Favorite Moneyline: -136, Underdog Moneyline: +116)
• 6/24/2025: 4-3 SD (Favorite: Padres, Spread: -1.5, Total: 8.5, Favorite Moneyline: -168, Underdog Moneyline: +142)
• 6/23/2025: 10-6 WSH (Favorite: Padres, Spread: -1.5, Total: 8.5, Favorite Moneyline: -172, Underdog Moneyline: +144)
• 7/25/2024: 3-0 SD (Favorite: Padres, Spread: -1.5, Total: 9, Favorite Moneyline: -162, Underdog Moneyline: +136)
• 7/24/2024: 12-3 SD (Favorite: Padres, Spread: -1.5, Total: 8.5, Favorite Moneyline: -110, Underdog Moneyline: -106)
• 7/23/2024: 4-0 SD (Favorite: Nationals, Spread: -1.5, Total: 9.5, Favorite Moneyline: -116, Underdog Moneyline: -102)
• 6/26/2024: 8-5 SD (Favorite: Padres, Spread: -1.5, Total: 7.5, Favorite Moneyline: -188, Underdog Moneyline: +158)
• 6/25/2024: 9-7 SD (Favorite: Nationals, Spread: -1.5, Total: 7.5, Favorite Moneyline: -124, Underdog Moneyline: +106)
• 6/24/2024: 7-6 SD (Favorite: Padres, Spread: -1.5, Total: 7.5, Favorite Moneyline: -196, Underdog Moneyline: +164)
• 6/25/2023: 8-3 WSH (Favorite: Padres, Spread: -1.5, Total: 8, Favorite Moneyline: -215, Underdog Moneyline: +180)

Sign up for FanDuel Sportsbook and FanDuel Daily Fantasy today!