Padres vs Guardians Prediction, Odds, Moneyline, Spread & Over/Under for March 31

Odds updated as of 9:12 p.m.

In MLB action on Monday, the San Diego Padres face the Cleveland Guardians.

Before you do any MLB betting on this matchup at FanDuel Sportsbook, here's everything you need to know.

Padres vs Guardians Game Info

• San Diego Padres (4-0) vs. Cleveland Guardians (2-1)
• Date: Monday, March 31, 2025
• Time: 9:40 p.m. ET
• Venue: PETCO Park -- San Diego, California
• Coverage: SDPA and CLEG

Padres vs Guardians Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: SD: (-130) | CLE: (+110)
• Spread: SD: -1.5 (+160) | CLE: +1.5 (-194)
• Total: 8 -- Over: (-112) | Under: (-108)

Padres vs Guardians Probable Starting Pitchers

Probable Pitchers: Kyle Hart (Padres) - 0-0, 0.00 ERA vs Luis Ortiz (Guardians) - 0-0, 0.00 ERA

The Padres will give the nod to Kyle Hart against the Guardians and Luis Ortiz. Hart did not appear in a game when his team was the moneyline favorite last season. Last season when Ortiz pitched his team finished 12-3-0 against the spread. Ortiz and his team put together a 6-6 record in the 12 games he appeared in when they were the moneyline underdog a season ago.

Padres vs Guardians Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Padres win (52.3%)

Padres vs Guardians Moneyline

• The moneyline numbers for Padres vs. Guardians reveal San Diego as the favorite (-130) and Cleveland as the underdog (+110) on the road.

Padres vs Guardians Spread

• The Padres are hosting the Guardians and are favored by 1.5 runs (+160 to cover) on the runline. Cleveland is -194 to cover.

Padres vs Guardians Over/Under

• Padres versus Guardians, on March 31, has an over/under of 8, with the over being -112 and the under -108.

Bet on San Diego Padres vs. Cleveland Guardians on FanDuel today!

Padres vs Guardians Betting Trends

• The Padres came away with 60 wins in the 102 contests they were listed as the favorites last season.
• Last year, San Diego won 45 of 71 games when listed as at least -130 on the moneyline.
• The Padres and their opponents hit the over in 87 of their 167 games with a total last season.
• The Guardians went 27-37 in games they were the underdog on the moneyline last season (winning 42.2% of those games).
• Cleveland went 11-20 in games it played as a moneyline underdog with odds of +110 or longer (35.5%).
• The Guardians combined with their opponents to go over the total 75 times last season for a 75-85-9 record against the over/under.

Padres Player Leaders

• Manny Machado ended his last campaign with 163 hits, an OBP of .325 plus a slugging percentage of .472.
• Jackson Merrill slashed .292/.326/.500 and finished with an OPS of .826.
• Luis Arraez had an OBP of .346 to go with a slugging percentage of .392 last season.
• Jake Cronenworth slashed .241/.324/.390 and finished with an OPS of .714.

Guardians Player Leaders

• Jose Ramirez accumulated a slugging percentage of .537 while collecting 173 hits a season ago.
• Steven Kwan had an on-base percentage of .368 while batting .292.
• Carlos Santana had 26 doubles, 23 home runs and 65 walks while hitting .238 last season.
• Lane Thomas hit .237 with 26 doubles, three triples, 15 home runs and 44 walks.

Sign up for FanDuel Sportsbook and FanDuel Daily Fantasy today!