Padres vs Diamondbacks Prediction, Odds, Moneyline, Spread & Over/Under for Aug. 6

Odds updated as of 9:12 p.m.

The San Diego Padres versus the Arizona Diamondbacks is on the MLB schedule for Wednesday.

Before checking out the MLB betting lines on FanDuel Sportsbook, we've got you covered, in terms of the vital information regarding this game.

Padres vs Diamondbacks Game Info

• San Diego Padres (63-51) vs. Arizona Diamondbacks (54-60)
• Date: Wednesday, August 6, 2025
• Time: 9:40 p.m. ET
• Venue: Chase Field -- Phoenix, Arizona
• Coverage: MLB Network, ARID, and SDPA

Padres vs Diamondbacks Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: SD: (-136) | ARI: (+116)
• Spread: SD: -1.5 (+115) | ARI: +1.5 (-138)
• Total: 9.5 -- Over: (-102) | Under: (-120)

Padres vs Diamondbacks Probable Starting Pitchers

Probable Pitchers: Nestor Cortes (Padres) - 1-1, 9.00 ERA vs Anthony DeSclafani (Diamondbacks) - 1-2, 4.91 ERA

The Padres will give the ball to Nestor Cortes (1-1, 9.00 ERA), who is eyeing win No. 2 on the season, and the Diamondbacks will counter with Anthony DeSclafani (1-2, 4.91 ERA). Cortes has a record of 1-1-0 ATS in two starts with a spread this season. Cortes' team won his only start as a favorite this season. DeSclafani has started two games with set spreads, and the Diamondbacks failed to cover in both opportunities. The Diamondbacks were named the moneyline underdog for one DeSclafani start this season -- they lost.

Padres vs Diamondbacks Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Diamondbacks win (51.2%)

Padres vs Diamondbacks Moneyline

• The moneyline numbers for Padres vs. Diamondbacks reveal San Diego as the favorite (-136) and Arizona as the underdog (+116) despite being the home team.

Padres vs Diamondbacks Spread

• The Diamondbacks are +1.5 on the spread (-138 to cover), and San Diego is +115 to cover the runline.

Padres vs Diamondbacks Over/Under

• A total of 9.5 runs has been set for the Padres-Diamondbacks contest on Aug. 6, with the over available at -102 and the under at -120.

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Padres vs Diamondbacks Betting Trends

• The Padres have won in 35, or 60.3%, of the 58 contests they have been named as odds-on favorites in this year.
• San Diego has a record of 24-14 when favored by -136 or more this year.
• The Padres and their opponents have gone over in 47 of their 112 games with a total set by sportsbooks this season.
• The Padres have an against the spread mark of 62-50-0 in 112 games with a line this season.
• The Diamondbacks have won 44.2% of the games this season they were the underdog on the moneyline (19-24).
• Arizona has a record of 10-7 when it has played as a moneyline underdog with odds of +116 or longer (58.8%).
• In the 110 games oddsmakers have set an over/under for the Diamondbacks, they have combined with opponents to go over the total 55 times (55-49-6).
• The Diamondbacks have put together a 50-60-0 record against the spread this season.

Padres Player Leaders

• Manny Machado leads San Diego with 133 hits and a team-best slugging percentage of .505. He's batting .302 with an on-base percentage of .362.
• Among qualified batters in MLB, he is eighth in batting average, 26th in on-base percentage, and 18th in slugging.
• Machado has recorded at least one hit in two straight games. In his last five games he is hitting .300 with two doubles, two walks and an RBI.
• Fernando Tatis Jr. is batting .261 with 19 doubles, two triples, 17 home runs and 65 walks, while slugging .434 with an on-base percentage of .364.
• Among all qualifying players, he is 71st in batting average, 23rd in on-base percentage and 74th in slugging percentage.
• Luis Arraez has 129 hits this season and has a slash line of .294/.330/.401.
• Xander Bogaerts has been key for San Diego with 109 hits, an OBP of .338 plus a slugging percentage of .387.

Diamondbacks Player Leaders

• Geraldo Perdomo has a .426 slugging percentage, which paces the Diamondbacks. He's batting .278 with an on-base percentage of .379.
• Including all the qualifying hitters in the majors, his batting average is 36th, his on-base percentage ranks 10th, and he is 81st in slugging.
• Perdomo heads into this game on a three-game hitting streak. In his last five games he is batting .333 with two doubles and five walks.
• Corbin Carroll is hitting .247 with 20 doubles, 14 triples, 22 home runs and 37 walks. He's slugging .540 with an on-base percentage of .321.
• Including all qualified hitters, he is 109th in batting average, 98th in on-base percentage and ninth in slugging percentage.
• Ketel Marte has put up an on-base percentage of .389 and has 87 hits, both team-best figures for the Diamondbacks.
• Lourdes Gurriel Jr. has 21 doubles, two triples, 14 home runs and 26 walks while batting .249.

Padres vs Diamondbacks Head to Head

• 8/5/2025: 10-5 SD (Favorite: Padres, Spread: -1.5, Total: 9, Favorite Moneyline: -134, Underdog Moneyline: +114)
• 8/4/2025: 6-2 ARI (Favorite: Padres, Spread: -1.5, Total: 9, Favorite Moneyline: -130, Underdog Moneyline: +110)
• 7/10/2025: 4-3 SD (Favorite: Diamondbacks, Spread: -1.5, Total: 8.5, Favorite Moneyline: -124, Underdog Moneyline: +106)
• 7/9/2025: 8-2 ARI (Favorite: Padres, Spread: -1.5, Total: 8, Favorite Moneyline: -158, Underdog Moneyline: +134)
• 7/8/2025: 1-0 SD (Favorite: Padres, Spread: -1.5, Total: 7.5, Favorite Moneyline: -142, Underdog Moneyline: +120)
• 7/7/2025: 6-3 ARI (Favorite: Padres, Spread: -1.5, Total: 8, Favorite Moneyline: -130, Underdog Moneyline: +110)
• 6/15/2025: 8-2 SD (Favorite: Diamondbacks, Spread: -1.5, Total: 8.5, Favorite Moneyline: -138, Underdog Moneyline: +118)
• 6/14/2025: 8-7 ARI (Favorite: Diamondbacks, Spread: -1.5, Total: 9.5, Favorite Moneyline: -168, Underdog Moneyline: +142)
• 6/13/2025: 5-1 ARI (Favorite: Diamondbacks, Spread: -1.5, Total: 9.5, Favorite Moneyline: -136, Underdog Moneyline: +116)
• 9/29/2024: 11-2 ARI (Favorite: Diamondbacks, Spread: -1.5, Total: 8.5, Favorite Moneyline: -220, Underdog Moneyline: +184)

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