Padres vs Cubs Prediction, Odds, Moneyline, Spread & Over/Under for NL Wild Card Game 1 on Sept. 29

Odds updated as of 9:11 p.m.

The Tuesday schedule in the MLB includes a matchup between the San Diego Padres and the Chicago Cubs in Game 1 of the NL Wild Card Series.

Here's what you need to know before checking out today's MLB odds and spreads on FanDuel Sportsbook.

Padres vs Cubs Game Info

• San Diego Padres (91-71) vs. Chicago Cubs (89-73)
• Date: Tuesday, September 29, 2026
• Time: 10 p.m. ET
• Venue: Petco Park -- San Diego, California
• Coverage: NBCSN and Peacock

Padres vs Cubs Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: SD: (-134) | CHC: (+116)
• Spread: SD: -1.5 (+164) | CHC: +1.5 (-200)
• Total: 7.5 -- Over: (-108) | Under: (-112)

Padres vs Cubs Probable Starting Pitchers

Probable Pitchers: Michael King (Padres) - 12-10, 3.21 ERA vs Matthew Boyd (Cubs) - 10-5, 3.91 ERA

The probable pitchers are Michael King (12-10, 3.21 ERA) for the Padres and Matthew Boyd (10-5, 3.91 ERA) for the Cubs. When King starts, his team is 12-20-0 against the spread this season. When King starts a game and his team is the favorite on the moneyline, they have a record of 11-10. When Boyd starts, the Cubs are 10-11-0 against the spread. The Cubs have a 1-4 record in Boyd's five starts this season when they were the underdog on the moneyline.

Padres vs Cubs Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Padres win (51.1%)

Padres vs Cubs Moneyline

• Looking at the moneyline for Cubs-Padres, Chicago is the underdog at +116, and San Diego is -134 playing at home.

Padres vs Cubs Spread

• The Padres are 1.5-run home favorites on the runline against the Cubs. The Padres are +164 to cover, and the Cubs are -200.

Padres vs Cubs Over/Under

• Padres versus Cubs, on Sept. 29, has an over/under of 7.5, with the over being -108 and the under -112.

Bet on San Diego Padres vs. Chicago Cubs on FanDuel today!

Padres vs Cubs Betting Trends

• The Padres have come away with 49 wins in the 80 contests they have been listed as the favorites in this season.
• This season San Diego has been victorious 31 times in 44 chances when named as a favorite of at least -134 on the moneyline.
• The Padres and their opponents have gone over the total this season in 77 of their 162 opportunities.
• The Padres have an against the spread record of 94-68-0 in 162 games with a line this season.
• The Cubs have gone 23-22 in games they were listed as the moneyline underdog (winning 51.1% of those games).
• Chicago is 8-4 (winning 66.7% of its games) when it has played as a moneyline underdog of +116 or longer.
• The Cubs have combined with opponents to hit the over on the total 89 times this season for an 89-68-0 record against the over/under.
• The Cubs have covered 47.1% of their games this season, going 74-83-0 against the spread.

Padres Player Leaders

• Fernando Tatis Jr. has an OPS of .828, fueled by an OBP of .358 and a team-best slugging percentage of .470 this season. He has a .289 batting average.
• Among qualified batters in MLB, he ranks 13th in batting average, 36th in on-base percentage, and 34th in slugging.
• Jackson Merrill is hitting .254 with 26 doubles, five triples, 26 home runs and 41 walks, while slugging .440 with an on-base percentage of .303.
• Among qualifiers, he ranks 74th in batting average, 113th in on-base percentage and 56th in slugging percentage.
• Merrill has picked up a hit in three games in a row. During his last five outings he is batting .222 with a double, a walk and an RBI.
• Manny Machado has 128 hits this season and has a slash line of .217/.303/.407.
• Machado enters this game with two games in a row with at least one hit. In his last five games he is hitting .211 with two home runs and seven RBIs.
• Xander Bogaerts has 13 home runs, 57 RBI and a batting average of .231 this season.
• Bogaerts has hit safely in two games in a row. In his last five games he is hitting .308 with a home run, four walks and an RBI.

Cubs Player Leaders

• Pete Crow-Armstrong has totaled 175 hits with a .372 on-base percentage and a .570 slugging percentage, all club-bests for the Cubs. He's batting .280.
• Including all qualified hitters in the big leagues, he is 26th in batting average, 14th in on-base percentage and second in slugging percentage.
• Alex Bregman is batting .265 with 33 doubles, two triples, 28 home runs and 76 walks. He's slugging .464 with an on-base percentage of .355.
• Including all qualifying hitters, he is 48th in batting average, 39th in on-base percentage and 39th in slugging percentage.
• Seiya Suzuki has 31 doubles, a triple, 26 home runs and 81 walks while batting .270.
• Nico Hoerner is batting .263 with 29 doubles, a triple, eight home runs and 43 walks.

Padres vs Cubs Head to Head

• 7/1/2026: 23-3 CHC (Favorite: Cubs, Spread: -1.5, Total: 12, Favorite Moneyline: -120, Underdog Moneyline: +102)
• 6/30/2026: 9-7 CHC (Favorite: Cubs, Spread: -1.5, Total: 11.5, Favorite Moneyline: -154, Underdog Moneyline: +130)
• 6/29/2026: 3-2 CHC (Favorite: Cubs, Spread: -1.5, Total: 11.5, Favorite Moneyline: -158, Underdog Moneyline: +134)
• 4/29/2026: 5-4 CHC (Favorite: Padres, Spread: -1.5, Total: 8.5, Favorite Moneyline: -112, Underdog Moneyline: -104)
• 4/28/2026: 8-3 CHC (Favorite: Cubs, Spread: -1.5, Total: 8.5, Favorite Moneyline: -118, Underdog Moneyline: +100)
• 4/27/2026: 9-7 SD (Favorite: Padres, Spread: -1.5, Total: 7.5, Favorite Moneyline: -116, Underdog Moneyline: -102)
• 10/2/2025: 3-1 CHC (Favorite: Cubs, Spread: -1.5, Total: 7.5, Favorite Moneyline: -116, Underdog Moneyline: -102)
• 10/1/2025: 3-0 SD (Favorite: Cubs, Spread: -1.5, Total: 6.5, Favorite Moneyline: -116, Underdog Moneyline: -102)
• 9/30/2025: 3-1 CHC (Favorite: Cubs, Spread: -1.5, Total: 6.5, Favorite Moneyline: -126, Underdog Moneyline: +108)
• 4/16/2025: 4-2 SD (Favorite: Padres, Spread: -1.5, Total: 7.5, Favorite Moneyline: -108, Underdog Moneyline: -108)

Sign up for FanDuel Sportsbook and FanDuel Daily Fantasy today!