Padres vs Cubs Prediction, Odds, Moneyline, Spread & Over/Under for NL Wild Card Game 1 on Sept. 29

Odds updated as of 5:11 a.m.

The MLB slate on Tuesday includes the San Diego Padres facing the Chicago Cubs in Game 1 of the NL Wild Card Series.

Before you do any MLB betting on this game at FanDuel Sportsbook, here's everything you need to know.

Padres vs Cubs Game Info

• San Diego Padres (91-71) vs. Chicago Cubs (89-73)
• Date: Tuesday, September 29, 2026
• Time: 10 p.m. ET
• Venue: Petco Park -- San Diego, California
• Coverage: NBCSN and Peacock

Padres vs Cubs Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: SD: (-126) | CHC: (+108)
• Spread: SD: -1.5 (+176) | CHC: +1.5 (-215)
• Total: 7.5 -- Over: (+102) | Under: (-124)

Padres vs Cubs Probable Starting Pitchers

Probable Pitchers: Michael King (Padres) - 12-10, 3.21 ERA vs Matthew Boyd (Cubs) - 10-5, 3.91 ERA

The Padres will give the nod to Michael King (12-10, 3.21 ERA) against the Cubs and Matthew Boyd (10-5, 3.91 ERA). King's team is 12-20-0 against the spread this season in his starts. King's team has been victorious in 52.4% of the games he's started as the moneyline favorite with a record of 11-10. When Boyd starts, the Cubs are 10-11-0 against the spread. The Cubs are 1-4 in Boyd's five starts this season that they were the underdog on the moneyline.

Padres vs Cubs Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Padres win (53.1%)

Padres vs Cubs Moneyline

• Looking at the moneyline for Cubs-Padres, Chicago is the underdog at +108, and San Diego is -126 playing at home.

Padres vs Cubs Spread

• The Padres are favored by 1.5 runs at home against the Cubs. The Padres are +176 to cover the spread, while the Cubs are -215.

Padres vs Cubs Over/Under

• An over/under of 7.5 has been set for Padres-Cubs on Sept. 29, with the over being +102 and the under -124.

Bet on San Diego Padres vs. Chicago Cubs on FanDuel today!

Padres vs Cubs Betting Trends

• The Padres have been victorious in 49, or 61.3%, of the 80 contests they have been chosen as favorites in this season.
• This year San Diego has won 34 of 55 games when listed as at least -126 on the moneyline.
• Contests with the Padres have gone over the total set by bookmakers in 77 of 162 chances this season.
• In 162 games with a line this season, the Padres have a mark of 94-68-0 against the spread.
• The Cubs have compiled a 23-22 record in games they were listed as the moneyline underdog (winning 51.1% of those games).
• In games it has played as a moneyline underdog with odds of +108 or longer, Chicago has a 9-9 record (winning 50% of its games).
• In the 157 games bookmakers have set an over/under for the Cubs, they have combined with opponents to go over the total 89 times (89-68-0).
• The Cubs have collected a 74-83-0 record ATS this season (covering 47.1% of the time).

Padres Player Leaders

• Fernando Tatis Jr. leads San Diego with a slugging percentage of .470, fueled by 60 extra-base hits. He has a .289 batting average and an on-base percentage of .358.
• Among all qualified batters in the majors, he ranks 13th in batting average, 36th in on-base percentage, and 34th in slugging.
• Jackson Merrill is batting .254 with 26 doubles, five triples, 26 home runs and 41 walks. He's slugging .440 with an on-base percentage of .303.
• Among all qualifying players, he is 74th in batting average, 113th in on-base percentage and 56th in slugging percentage.
• Merrill enters this game looking to extend his three-game hit streak. In his last five games he is hitting .222 with a double, a walk and an RBI.
• Manny Machado is batting .217 with a .407 slugging percentage and 91 RBI this year.
• Machado takes a two-game hitting streak into this game. In his last five games he is batting .211 with two home runs and seven RBIs.
• Xander Bogaerts has been key for San Diego with 120 hits, an OBP of .332 plus a slugging percentage of .344.
• Bogaerts enters this game on a two-game hitting streak. In his last five games he is batting .308 with a home run, four walks and an RBI.

Cubs Player Leaders

• Pete Crow-Armstrong has put up an on-base percentage of .372, a slugging percentage of .570, and has 175 hits, all club-bests for the Cubs (while batting .280).
• He ranks 26th in batting average, 14th in on-base percentage and second in slugging percentage among all qualifying hitters in MLB.
• Alex Bregman is batting .265 with 33 doubles, two triples, 28 home runs and 76 walks. He's slugging .464 with an on-base percentage of .355.
• His batting average ranks 48th among all qualified players, his on-base percentage ranks 39th, and he is 39th in slugging.
• Seiya Suzuki is hitting .270 with 31 doubles, a triple, 26 home runs and 81 walks.
• Nico Hoerner is hitting .263 with 29 doubles, a triple, eight home runs and 43 walks.

Padres vs Cubs Head to Head

• 7/1/2026: 23-3 CHC (Favorite: Cubs, Spread: -1.5, Total: 12, Favorite Moneyline: -120, Underdog Moneyline: +102)
• 6/30/2026: 9-7 CHC (Favorite: Cubs, Spread: -1.5, Total: 11.5, Favorite Moneyline: -154, Underdog Moneyline: +130)
• 6/29/2026: 3-2 CHC (Favorite: Cubs, Spread: -1.5, Total: 11.5, Favorite Moneyline: -158, Underdog Moneyline: +134)
• 4/29/2026: 5-4 CHC (Favorite: Padres, Spread: -1.5, Total: 8.5, Favorite Moneyline: -112, Underdog Moneyline: -104)
• 4/28/2026: 8-3 CHC (Favorite: Cubs, Spread: -1.5, Total: 8.5, Favorite Moneyline: -118, Underdog Moneyline: +100)
• 4/27/2026: 9-7 SD (Favorite: Padres, Spread: -1.5, Total: 7.5, Favorite Moneyline: -116, Underdog Moneyline: -102)
• 10/2/2025: 3-1 CHC (Favorite: Cubs, Spread: -1.5, Total: 7.5, Favorite Moneyline: -116, Underdog Moneyline: -102)
• 10/1/2025: 3-0 SD (Favorite: Cubs, Spread: -1.5, Total: 6.5, Favorite Moneyline: -116, Underdog Moneyline: -102)
• 9/30/2025: 3-1 CHC (Favorite: Cubs, Spread: -1.5, Total: 6.5, Favorite Moneyline: -126, Underdog Moneyline: +108)
• 4/16/2025: 4-2 SD (Favorite: Padres, Spread: -1.5, Total: 7.5, Favorite Moneyline: -108, Underdog Moneyline: -108)

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