Orioles vs White Sox Prediction, Odds, Moneyline, Spread & Over/Under for Sept. 15

Odds updated as of 7:15 p.m.

The Monday slate in MLB includes a matchup between the Baltimore Orioles and the Chicago White Sox.

Here's everything you need to know before checking out today's MLB odds and spreads on FanDuel Sportsbook.

Orioles vs White Sox Game Info

• Baltimore Orioles (69-80) vs. Chicago White Sox (57-93)
• Date: Monday, September 15, 2025
• Time: 7:40 p.m. ET
• Venue: Rate Field -- Chicago, Illinois
• Coverage: CHSN and MASN2

Orioles vs White Sox Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: BAL: (-142) | CHW: (+120)
• Spread: BAL: -1.5 (+116) | CHW: +1.5 (-140)
• Total: 8 -- Over: (-110) | Under: (-110)

Orioles vs White Sox Probable Starting Pitchers

Probable Pitchers: Kyle Bradish (Orioles) - 0-1, 2.65 ERA vs Sean Burke (White Sox) - 4-10, 4.35 ERA

The Orioles will give the ball to Kyle Bradish (0-1, 2.65 ERA), who is eyeing win No. 1 on the season, and the White Sox will turn to Sean Burke (4-10, 4.35 ERA). Bradish and his team have a record of 1-2-0 against the spread when he starts. Bradish's team won his only start as a favorite this season. The White Sox have a 12-9-0 record against the spread in Burke's starts. The White Sox are 9-12 in Burke's 21 starts this season that they were the moneyline underdog.

Orioles vs White Sox Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Orioles win (53.2%)

Orioles vs White Sox Moneyline

• Baltimore is the favorite, -142 on the moneyline, while Chicago is a +120 underdog despite being at home.

Orioles vs White Sox Spread

• The Orioles are at the White Sox and are favored by 1.5 runs on the spread. The Orioles are +116 to cover the runline, with the White Sox being -140.

Orioles vs White Sox Over/Under

• A combined run total of 8 has been set for Orioles-White Sox on Sept. 15, with the over at -110 and the under at -110.

Bet on Baltimore Orioles vs. Chicago White Sox on FanDuel today!

Orioles vs White Sox Betting Trends

• The Orioles have been favorites in 59 games this season and have come away with the win 28 times (47.5%) in those contests.
• This season Baltimore has come away with a win 10 times in 18 chances when named as a favorite of at least -142 on the moneyline.
• The Orioles and their opponents have gone over in 62 of their 146 games with a total set by sportsbooks this season.
• The Orioles have an against the spread mark of 70-76-0 in 146 games with a line this season.
• The White Sox have compiled a 53-89 record in games they were listed as the moneyline underdog (winning 37.3% of those games).
• Chicago has a record of 37-70 in games it has played as a moneyline underdog with odds of +120 or longer (34.6%).
• The White Sox have combined with opponents to hit the over on the total 67 times this season for a 67-70-8 record against the over/under.
• The White Sox have collected an 83-62-0 record ATS this season (covering 57.2% of the time).

Orioles Player Leaders

• Gunnar Henderson leads Baltimore in OBP (.347), slugging percentage (.442) and total hits (143) this season. He has a .271 batting average.
• He is 37th in batting average, 41st in on-base percentage, and 65th in slugging among qualifying hitters in baseball.
• Henderson hopes to build on a two-game hitting streak in this matchup. In his last five games he is hitting .250 with two doubles, three walks and an RBI.
• Jackson Holliday is batting .253 with 20 doubles, three triples, 17 home runs and 51 walks, while slugging .394 with an on-base percentage of .323.
• He is 87th in batting average, 89th in on-base percentage and 111th in slugging among qualifying batters.
• Holliday enters this game looking to extend his seven-game hit streak. During his last 10 outings he is hitting .361 with two home runs, seven walks and four RBIs.
• Ryan Mountcastle has collected 77 base hits, an OBP of .293 and a slugging percentage of .365 this season.
• Colton Cowser is batting .201 with a .271 OBP and 35 RBI for Baltimore this season.

White Sox Player Leaders

• Miguel Vargas has accumulated a team-best .313 on-base percentage. He's batting .232 and slugging .398.
• Including all qualified hitters, he ranks 129th in batting average, while his on-base percentage is 107th and he is 105th in slugging.
• Andrew Benintendi has 16 doubles, two triples, 19 home runs and 37 walks while hitting .241. He's slugging .427 with an on-base percentage of .304.
• Lenyn Sosa has 126 hits with a .429 slugging percentage, both team-best numbers for the White Sox.
• Chase Meidroth is hitting .269 with 15 doubles, five home runs and 43 walks.

Orioles vs White Sox Head to Head

• 6/1/2025: 3-2 BAL (Favorite: Orioles, Spread: -1.5, Total: 8.5, Favorite Moneyline: -146, Underdog Moneyline: +124)
• 5/31/2025: 4-2 BAL (Favorite: Orioles, Spread: -1.5, Total: 8.5, Favorite Moneyline: -168, Underdog Moneyline: +142)
• 5/30/2025: 2-1 BAL (Favorite: Orioles, Spread: -1.5, Total: 9, Favorite Moneyline: -210, Underdog Moneyline: +176)
• 9/4/2024: 8-1 CHW (Favorite: Orioles, Spread: -1.5, Total: 8.5, Favorite Moneyline: -375, Underdog Moneyline: +300)
• 9/3/2024: 9-0 BAL (Favorite: Orioles, Spread: -1.5, Total: 8.5, Favorite Moneyline: -320, Underdog Moneyline: +260)
• 9/2/2024: 13-3 BAL (Favorite: Orioles, Spread: -1.5, Total: 8, Favorite Moneyline: -460, Underdog Moneyline: +360)
• 5/25/2024: 5-3 BAL (Favorite: Orioles, Spread: -1.5, Total: 8.5, Favorite Moneyline: -172, Underdog Moneyline: +144)
• 5/24/2024: 6-4 BAL (Favorite: Orioles, Spread: -1.5, Total: 7.5, Favorite Moneyline: -250, Underdog Moneyline: +205)
• 5/23/2024: 8-6 BAL (Favorite: Orioles, Spread: -1.5, Total: 8, Favorite Moneyline: -240, Underdog Moneyline: +194)
• 8/30/2023: 10-5 CHW (Favorite: Orioles, Spread: -1.5, Total: 8.5, Favorite Moneyline: -180, Underdog Moneyline: +152)

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