Orioles vs Guardians Prediction, Odds, Moneyline, Spread & Over/Under for April 16

Odds updated as of 6:11 p.m.

The Baltimore Orioles versus the Cleveland Guardians is on the MLB schedule for Wednesday.

We've got you covered, in terms of the vital info regarding this game before you take a look at the MLB odds and spreads on FanDuel Sportsbook.

Orioles vs Guardians Game Info

• Baltimore Orioles (6-10) vs. Cleveland Guardians (9-7)
• Date: Wednesday, April 16, 2025
• Time: 6:35 p.m. ET
• Venue: Oriole Park at Camden Yards -- Baltimore, Maryland
• Coverage: MASN2 and CLEG

Orioles vs Guardians Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: BAL: (-124) | CLE: (+106)
• Spread: BAL: -1.5 (+164) | CLE: +1.5 (-200)
• Total: 8 -- Over: (-110) | Under: (-110)

Orioles vs Guardians Probable Starting Pitchers

Probable Pitchers: Dean Kremer (Orioles) - 1-2, 8.16 ERA vs Gavin Williams (Guardians) - 1-0, 3.46 ERA

The probable starters are Dean Kremer (1-2) for the Orioles and Gavin Williams (1-0) for the Guardians. Kremer's team is 1-2-0 against the spread this season in his starts. Kremer's team lost his only start as a favorite this season. The Guardians have gone 2-1-0 ATS in Williams' three starts with a set spread. The Guardians were named the moneyline underdog for one Williams start this season -- they lost.

Orioles vs Guardians Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Orioles win (51.1%)

Orioles vs Guardians Moneyline

• Baltimore is the favorite, -124 on the moneyline, while Cleveland is a +106 underdog on the road.

Orioles vs Guardians Spread

• The Guardians are +1.5 on the run line against the Orioles. The Guardians are -200 to cover, and the Orioles are +164.

Orioles vs Guardians Over/Under

• The over/under for the Orioles versus Guardians contest on April 16 has been set at 8, with -110 odds on the over and -110 odds on the under.

Bet on Baltimore Orioles vs. Cleveland Guardians on FanDuel today!

Orioles vs Guardians Betting Trends

• The Orioles have been favorites in seven games this season and have come away with the win two times (28.6%) in those contests.
• This year Baltimore has won two of five games when listed as at least -124 on the moneyline.
• The Orioles and their opponents have gone over in 10 of their 16 games with a total set by sportsbooks this season.
• The Orioles are 5-11-0 against the spread in their 16 games that had a posted line this season.
• The Guardians have put together a 3-5 record in games they were listed as the moneyline underdog (winning 37.5% of those games).
• When playing as a moneyline underdog with odds of +106 or longer, Cleveland has a record of 2-4 (33.3%).
• The Guardians have played in 16 games with a set over/under, and have combined with their opponents to go over the total eight times (8-8-0).
• The Guardians are 7-9-0 against the spread this season.

Orioles Player Leaders

• Cedric Mullins has 15 hits and an OBP of .435 to go with a slugging percentage of .620. All three of those stats are tops among Baltimore hitters this season. He has a .300 batting average, as well.
• Among qualified hitters in MLB, his batting average ranks 35th, his on-base percentage ranks seventh, and he is ninth in slugging.
• Adley Rutschman is hitting .237 with two doubles, three home runs and seven walks, while slugging .424 with an on-base percentage of .318.
• His batting average is 92nd among qualified players, his on-base percentage 88th, and his slugging percentage 74th.
• Tyler O'Neill is batting .265 with a .490 slugging percentage and eight RBI this year.
• Ryan O'Hearn is batting .275 with a .356 OBP and one RBI for Baltimore this season.
• O'Hearn enters this game on a two-game hitting streak. In his last five games he is hitting .214 with two walks.

Guardians Player Leaders

• Steven Kwan has a .391 on-base percentage and a .492 slugging percentage, both team-best marks for the Guardians. He's batting .333.
• Including all qualifying hitters, he is ninth in batting average, while his on-base percentage ranks 25th and he is 42nd in slugging.
• Kwan takes a five-game hitting streak into this game. During his last five outings he is batting .391 with two home runs, a walk and eight RBI.
• Jose Ramirez's 13 hits lead his team. He has a batting average of .250 while slugging .519 with an on-base percentage of .323.
• Including all qualifying players, he is 77th in batting average, 83rd in on-base percentage and 32nd in slugging percentage.
• Kyle Manzardo is batting .176 with a double, a triple, four home runs and 10 walks.
• Carlos Santana is hitting .246 with two doubles, two home runs and seven walks.

Orioles vs Guardians Head to Head

• 4/15/2025: 6-3 CLE (Favorite: Orioles, Spread: -1.5, Total: 8.5, Favorite Moneyline: -152, Underdog Moneyline: +128)
• 8/4/2024: 9-5 BAL (Favorite: Orioles, Spread: -1.5, Total: 7.5, Favorite Moneyline: -126, Underdog Moneyline: +108)
• 8/3/2024: 7-4 BAL (Favorite: Orioles, Spread: -1.5, Total: 8.5, Favorite Moneyline: -116, Underdog Moneyline: -102)
• 8/2/2024: 8-4 CLE (Favorite: Orioles, Spread: -1.5, Total: 9, Favorite Moneyline: -112, Underdog Moneyline: -104)
• 8/1/2024: 10-3 CLE (Favorite: Guardians, Spread: -1.5, Total: 9, Favorite Moneyline: -112, Underdog Moneyline: -104)
• 6/26/2024: 4-2 BAL (Favorite: Orioles, Spread: -1.5, Total: 9, Favorite Moneyline: -225, Underdog Moneyline: +188)
• 6/25/2024: 10-8 CLE (Favorite: Orioles, Spread: -1.5, Total: 9, Favorite Moneyline: -158, Underdog Moneyline: +134)
• 6/24/2024: 3-2 CLE (Favorite: Orioles, Spread: -1.5, Total: 8, Favorite Moneyline: -116, Underdog Moneyline: -102)
• 9/24/2023: 5-1 BAL (Favorite: Guardians, Spread: -1.5, Total: 7.5, Favorite Moneyline: -110, Underdog Moneyline: -106)
• 9/23/2023: 2-1 BAL (Favorite: Orioles, Spread: -1.5, Total: 8, Favorite Moneyline: -126, Underdog Moneyline: +108)

Sign up for FanDuel Sportsbook and FanDuel Daily Fantasy today!