Orioles vs Giants Prediction, Odds, Moneyline, Spread & Over/Under for April 10

Odds updated as of 7:11 p.m.

The Baltimore Orioles versus the San Francisco Giants is on the MLB schedule for Friday.

Here's everything you need to know before checking out today's MLB odds and spreads on FanDuel Sportsbook.

Orioles vs Giants Game Info

• Baltimore Orioles (6-6) vs. San Francisco Giants (5-8)
• Date: Friday, April 10, 2026
• Time: 7:15 p.m. ET
• Venue: Oriole Park at Camden Yards -- Baltimore, Maryland
• Coverage: Apple TV+

Orioles vs Giants Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: BAL: (-118) | SF: (+100)
• Spread: BAL: +1.5 (-196) | SF: -1.5 (+162)
• Total: 8.5 -- Over: (+100) | Under: (-122)

Orioles vs Giants Probable Starting Pitchers

Probable Pitchers: Shane Baz (Orioles) - 0-0, 4.09 ERA vs Landen Roupp (Giants) - 1-1, 4.22 ERA

The probable pitchers are Shane Baz for the Orioles and Landen Roupp (1-1) for the Giants. Baz has a record of 1-1-0 ATS in two starts with a spread this season. Baz's team won his only start as a favorite this season. Roupp has started two games with set spreads, and the Giants failed to cover in both opportunities. The Giants were the underdog on the moneyline for one Roupp start this season -- they won.

Orioles vs Giants Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Giants win (53.3%)

Orioles vs Giants Moneyline

• Baltimore is the favorite, -118 on the moneyline, while San Francisco is a +100 underdog on the road.

Orioles vs Giants Spread

• The Giants are 1.5-run favorites against the spread for this matchup with the Orioles. The Giants are +162 to cover, while the Orioles are -196 to cover as a 1.5-run underdog on the runline.

Orioles vs Giants Over/Under

• Orioles versus Giants, on April 10, has an over/under of 8.5, with the over being +100 and the under -122.

Bet on Baltimore Orioles vs. San Francisco Giants on FanDuel today!

Orioles vs Giants Betting Trends

• The Orioles have been victorious in six of the nine contests they have been chosen as favorites in this season.
• Baltimore has a record of 5-3 when favored by -118 or more this year.
• Contests with the Orioles have gone over the total set by sportsbooks in six of 12 chances this season.
• The Orioles are 4-8-0 against the spread in their 12 games with a line set by sportsbooks this season.
• The Giants have gone 4-6 in games they were the underdog on the moneyline (winning 40% of those games).
• When playing as a moneyline underdog with odds of +100 or longer, San Francisco has a record of 3-5 (37.5%).
• The Giants have had an over/under set by bookmakers 13 times, and have combined with opponents to go over the total in five of those games (5-5-3).
• The Giants have gone 4-9-0 against the spread this season.

Orioles Player Leaders

• Taylor Ward leads Baltimore in OBP (.464), slugging percentage (.574) and total hits (18) this season. He has a .383 batting average.
• Among the qualifying hitters in MLB, his batting average ranks fourth, his on-base percentage ranks sixth, and he is 18th in slugging.
• Ward will look for his fifth straight game with a hit in this contest. In his last five games he is hitting .450 with six doubles, three walks and three RBIs.
• Gunnar Henderson is batting .245 with three doubles, four home runs and six walks, while slugging .551 with an on-base percentage of .339.
• He ranks 77th in batting average, 74th in on-base percentage and 27th in slugging in the majors.
• Henderson brings a three-game streak with at least one hit into this matchup. During his last five outings he is hitting .263 with a double, two home runs, four walks and three RBIs.
• Tyler O'Neill is batting .241 with a .345 slugging percentage and four RBI this year.
• O'Neill has picked up a hit in four games in a row. In his last five games he is hitting .333 with a walk and an RBI.
• Adley Rutschman has no home runs, but three RBI and a batting average of .241 this season.

Giants Player Leaders

• Luis Arraez has put up a slugging percentage of .420, a team-high for the Giants. He's batting .320 with an on-base percentage of .333.
• Including all the qualified hitters in MLB, his batting average ranks 23rd, his on-base percentage is 76th, and he is 75th in slugging.
• Arraez takes a four-game hitting streak into this matchup. In his last five games he is hitting .333 with a triple, a walk and three RBIs.
• Matt Chapman's 15 hits and .352 OBP both pace his team. He has a batting average of .300 while slugging .460.
• He is currently 33rd in batting average, 62nd in on-base percentage and 52nd in slugging percentage among all qualified hitters.
• Willy Adames has accumulated 13 hits, a team-best for the Giants.
• Rafael Devers is batting .220 with a double, two home runs and four walks.

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