Orioles vs Astros Prediction, Odds, Moneyline, Spread & Over/Under for April 29

Odds updated as of 2:11 a.m.

The Wednesday schedule in MLB includes a matchup between the Baltimore Orioles and the Houston Astros.

All the information you need to make smart wagers on this game at FanDuel Sportsbook can be found below. Check out all of the latest MLB betting lines here.

Orioles vs Astros Game Info

• Baltimore Orioles (14-15) vs. Houston Astros (11-19)
• Date: Wednesday, April 29, 2026
• Time: 6:35 p.m. ET
• Venue: Oriole Park at Camden Yards -- Baltimore, Maryland
• Coverage: MASN and SCHN

Orioles vs Astros Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: BAL: (-122) | HOU: (+104)
• Spread: BAL: +1.5 (-200) | HOU: -1.5 (+164)
• Total: 9 -- Over: (-105) | Under: (-115)

Orioles vs Astros Probable Starting Pitchers

Probable Pitchers: Chris Bassitt (Orioles) - 1-2, 6.75 ERA vs Peter Lambert (Astros) - 1-1, 3.27 ERA

The Orioles will give the nod to Chris Bassitt (1-2, 6.75 ERA), who is eyeing win No. 2 on the season, and the Astros will turn to Peter Lambert (1-1, 3.27 ERA). Bassitt and his team have a record of 3-2-0 against the spread when he starts. Bassitt's team lost his only start as a favorite this season. Lambert has started two games with set spreads, and the Astros went 1-1-0. The Astros were the underdog on the moneyline for one Lambert start this season -- they won.

Orioles vs Astros Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Orioles win (51.8%)

Orioles vs Astros Moneyline

• Looking at the moneyline for Astros-Orioles, Houston is the underdog at +104, and Baltimore is -122 playing at home.

Orioles vs Astros Spread

• The Astros are 1.5-run favorites against the spread for this matchup with the Orioles. The Astros are +164 to cover, while the Orioles are -200 to cover as a 1.5-run underdog on the runline.

Orioles vs Astros Over/Under

• A combined run total of 9 has been set for Orioles-Astros on April 29, with the over at -105 and the under at -115.

Bet on Baltimore Orioles vs. Houston Astros on FanDuel today!

Orioles vs Astros Betting Trends

• The Orioles have come away with 11 wins in the 19 contests they have been listed as the favorites in this season.
• This season Baltimore has been victorious nine times in 15 chances when named as a favorite of at least -122 on the moneyline.
• The Orioles and their opponents have hit the over in 18 of their 29 games with a total set by oddsmakers this season.
• In 29 games with a line this season, the Orioles have a mark of 13-16-0 against the spread.
• The Astros have won 38.5% of the games this season they were the moneyline underdog (5-8).
• Houston has a record of 5-8 in games it has played as a moneyline underdog with odds of +104 or longer (38.5%).
• In the 30 games bookmakers have set an over/under for the Astros, they have combined with opponents to go over the total 21 times (21-9-0).
• The Astros have put together an 11-19-0 record against the spread this season (covering only 36.7% of the time).

Orioles Player Leaders

• Taylor Ward has an OPS of .882, fueled by an OBP of .426 to go with a slugging percentage of .455. He has a .313 batting average, as well.
• Among qualifying hitters, he is 15th in batting average, his on-base percentage ranks fifth, and he is 59th in slugging.
• Gunnar Henderson leads Baltimore in total hits (26) this season while batting .213 with 15 extra-base hits. He's slugging .492 with an on-base percentage of .287.
• Among qualified batters, his batting average places him 144th, his on-base percentage 150th, and his slugging percentage 36th.
• Henderson has picked up at least one hit in two straight games. In his last five games he is batting .286 with a double, two home runs, a walk and three RBIs.
• Jeremiah Jackson is batting .272 with a .457 slugging percentage and 19 RBI this year.
• Adley Rutschman has been key for Baltimore with 19 hits, an OBP of .400 plus a slugging percentage of .618.
• Rutschman has safely hit in six games in a row. In his last 10 games he is batting .366 with three doubles, three home runs, two walks and 12 RBIs.

Astros Player Leaders

• Yordan Alvarez has accumulated 39 hits with a .463 on-base percentage and a .736 slugging percentage, all club-bests for the Astros. He's batting .355.
• Including all qualifying players in the majors, he ranks first in batting average, first in on-base percentage and first in slugging percentage.
• Alvarez heads into this matchup on a 13-game hitting streak. In his last 10 outings he is batting .395 with three doubles, four home runs, two walks and eight RBIs.
• Christian Walker has nine doubles, seven home runs and 13 walks while hitting .299. He's slugging .579 with an on-base percentage of .377.
• He ranks 23rd in batting average, 25th in on-base percentage and eighth in slugging percentage in MLB.
• Carlos Correa has seven doubles, two home runs and 15 walks while hitting .277.
• Jose Altuve has seven doubles, three home runs and 16 walks while batting .248.

Orioles vs Astros Head to Head

• 4/28/2026: 5-3 BAL (Favorite: Orioles, Spread: -1.5, Total: 9, Favorite Moneyline: -136, Underdog Moneyline: +116)
• 8/24/2025: 3-2 BAL (Favorite: Orioles, Spread: -1.5, Total: 9, Favorite Moneyline: -132, Underdog Moneyline: +112)
• 8/23/2025: 9-8 HOU (Favorite: Orioles, Spread: -1.5, Total: 9, Favorite Moneyline: -118, Underdog Moneyline: -100)
• 8/22/2025: 10-7 HOU (Favorite: Astros, Spread: -1.5, Total: 9.5, Favorite Moneyline: -116, Underdog Moneyline: -102)
• 8/21/2025: 7-2 HOU (Favorite: Orioles, Spread: -1.5, Total: 8.5, Favorite Moneyline: -118, Underdog Moneyline: -100)
• 8/17/2025: 12-0 BAL (Favorite: Astros, Spread: -1.5, Total: 8.5, Favorite Moneyline: -130, Underdog Moneyline: +110)
• 8/16/2025: 5-4 HOU (Favorite: Astros, Spread: -1.5, Total: 8.5, Favorite Moneyline: -138, Underdog Moneyline: +118)
• 8/15/2025: 7-0 BAL (Favorite: Astros, Spread: -1.5, Total: 7.5, Favorite Moneyline: -220, Underdog Moneyline: +184)
• 8/25/2024: 6-3 HOU (Favorite: Orioles, Spread: -1.5, Total: 8, Favorite Moneyline: -110, Underdog Moneyline: -106)
• 8/24/2024: 3-2 BAL (Favorite: Orioles, Spread: -1.5, Total: 8.5, Favorite Moneyline: -110, Underdog Moneyline: -106)

Sign up for FanDuel Sportsbook and FanDuel Daily Fantasy today!