Orioles vs Astros Prediction, Odds, Moneyline, Spread & Over/Under for April 29

Odds updated as of 3:11 p.m.

On Thursday in MLB, the Baltimore Orioles are playing the Houston Astros.

We've got you covered, in terms of the vital information about this matchup before you take a look at the MLB odds and spreads on FanDuel Sportsbook.

Orioles vs Astros Game Info

• Baltimore Orioles (14-15) vs. Houston Astros (11-19)
• Date: Thursday, April 30, 2026
• Time: 4:05 p.m. ET
• Venue: Oriole Park at Camden Yards -- Baltimore, Maryland
• Coverage: MASN and SCHN

Orioles vs Astros Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: BAL: (-130) | HOU: (+110)
• Spread: BAL: -1.5 (+158) | HOU: +1.5 (-192)
• Total: 9 -- Over: (-112) | Under: (-108)

Orioles vs Astros Probable Starting Pitchers

Probable Pitchers: Brandon Young (Orioles) - 2-0, 2.53 ERA vs Lance McCullers (Astros) - 1-2, 6.75 ERA

The Orioles will look to Brandon Young (2-0) versus the Astros and Lance McCullers (1-2). Young has a record of 1-1-0 ATS in two starts with a spread this season. Young's team is 2-0 this season when he starts and they're favored on the moneyline. The Astros have a 2-3-0 ATS record in McCullers' five starts with a set spread. The Astros are 1-2 in McCullers' three starts this season that they were the moneyline underdog.

Orioles vs Astros Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Astros win (52.3%)

Orioles vs Astros Moneyline

• The Orioles vs Astros moneyline has Baltimore as a -130 favorite, while Houston is a +110 underdog on the road.

Orioles vs Astros Spread

• The Astros are +1.5 on the run line against the Orioles. The Astros are -192 to cover, and the Orioles are +158.

Orioles vs Astros Over/Under

• Orioles versus Astros, on April 30, has an over/under of 9, with the over being -112 and the under -108.

Bet on Baltimore Orioles vs. Houston Astros on FanDuel today!

Orioles vs Astros Betting Trends

• The Orioles have been favorites in 19 games this season and have come away with the win 11 times (57.9%) in those contests.
• Baltimore has a record of 7-4 when favored by -130 or more this year.
• Contests with the Orioles have gone over the total set by oddsmakers in 18 of 29 chances this season.
• The Orioles are 13-16-0 against the spread in their 29 games that had a posted line this season.
• The Astros have won five of the 13 games they were the moneyline underdog this season (38.5%).
• Houston is 3-8 (winning just 27.3% of its games) when it has played as a moneyline underdog of +110 or longer.
• In the 30 games bookmakers have set an over/under for the Astros, they have combined with opponents to go over the total 21 times (21-9-0).
• The Astros have collected an 11-19-0 record against the spread this season (covering just 36.7% of the time).

Orioles Player Leaders

• Taylor Ward leads Baltimore OPS (.882) this season. He has a .313 batting average, an on-base percentage of .426, and a slugging percentage of .455.
• Among all qualified batters, he ranks 20th in batting average, his on-base percentage ranks sixth, and he is 56th in slugging.
• Gunnar Henderson has 26 hits, which is best among Baltimore batters this season. He's batting .213 with 15 extra-base hits. He's also slugging .492 with an on-base percentage of .287.
• Among qualifiers, he is 142nd in batting average, 150th in on-base percentage and 34th in slugging percentage.
• Henderson brings a two-game streak with at least one hit into this one. During his last five outings he is batting .286 with a double, two home runs, a walk and three RBIs.
• Jeremiah Jackson has 25 hits this season and has a slash line of .272/.292/.457.
• Adley Rutschman has been key for Baltimore with 19 hits, an OBP of .400 plus a slugging percentage of .618.
• Rutschman takes a six-game hitting streak into this matchup. During his last 10 games he is hitting .366 with three doubles, three home runs, two walks and 12 RBIs.

Astros Player Leaders

• Yordan Alvarez has accumulated an on-base percentage of .463, a slugging percentage of .736, and has 39 hits, all club-bests for the Astros (while batting .355).
• He ranks third in batting average, first in on-base percentage and first in slugging percentage among all qualifying hitters in the majors.
• Alvarez enters this game on a 13-game hitting streak. In his last 10 outings he is hitting .395 with three doubles, four home runs, two walks and eight RBIs.
• Christian Walker is hitting .299 with nine doubles, seven home runs and 13 walks. He's slugging .579 with an on-base percentage of .377.
• Including all qualified players, he ranks 26th in batting average, 27th in on-base percentage and ninth in slugging percentage.
• Carlos Correa has seven doubles, two home runs and 15 walks while hitting .277.
• Jose Altuve is batting .248 with seven doubles, three home runs and 16 walks.

Orioles vs Astros Head to Head

• 4/28/2026: 5-3 BAL (Favorite: Orioles, Spread: -1.5, Total: 9, Favorite Moneyline: -136, Underdog Moneyline: +116)
• 8/24/2025: 3-2 BAL (Favorite: Orioles, Spread: -1.5, Total: 9, Favorite Moneyline: -132, Underdog Moneyline: +112)
• 8/23/2025: 9-8 HOU (Favorite: Orioles, Spread: -1.5, Total: 9, Favorite Moneyline: -118, Underdog Moneyline: -100)
• 8/22/2025: 10-7 HOU (Favorite: Astros, Spread: -1.5, Total: 9.5, Favorite Moneyline: -116, Underdog Moneyline: -102)
• 8/21/2025: 7-2 HOU (Favorite: Orioles, Spread: -1.5, Total: 8.5, Favorite Moneyline: -118, Underdog Moneyline: -100)
• 8/17/2025: 12-0 BAL (Favorite: Astros, Spread: -1.5, Total: 8.5, Favorite Moneyline: -130, Underdog Moneyline: +110)
• 8/16/2025: 5-4 HOU (Favorite: Astros, Spread: -1.5, Total: 8.5, Favorite Moneyline: -138, Underdog Moneyline: +118)
• 8/15/2025: 7-0 BAL (Favorite: Astros, Spread: -1.5, Total: 7.5, Favorite Moneyline: -220, Underdog Moneyline: +184)
• 8/25/2024: 6-3 HOU (Favorite: Orioles, Spread: -1.5, Total: 8, Favorite Moneyline: -110, Underdog Moneyline: -106)
• 8/24/2024: 3-2 BAL (Favorite: Orioles, Spread: -1.5, Total: 8.5, Favorite Moneyline: -110, Underdog Moneyline: -106)

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