Oregon vs USC Prediction, Odds, Picks, Best Bets for Week 13 2025

The Oregon Ducks versus the USC Trojans is on the college football schedule for Saturday.

We've got you covered, in terms of the vital information regarding NCAA football betting lines, before you make your wager on FanDuel Sportsbook.

Oregon vs USC Odds & Spread

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• All college football odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: Oregon: (-420) | USC: (+330)
• Spread: Oregon: -10.5 (-106) | USC: +10.5 (-114)
• Total: 59.5 -- Over: (-105) | Under: (-115)

Oregon vs USC Betting Trends

• Oregon has beaten the spread five times in 10 games.
• Oregon owns an ATS record of 4-3 as 10.5-point or greater favorites.
• This season, five of Oregon's 10 games have go over the point total.
• Against the spread, USC is 5-5-0 this year.
• USC has covered every time (1-0) as a 10.5-point or greater underdog this season.
• This year, five of USC's 10 games have gone over the point total.

Oregon vs USC Prediction & Pick

All college football win probability predictions and picks are according to numberFire.
Prediction: Ducks win (75.5%)

Oregon vs USC Point Spread

Oregon is a 10.5-point favorite against USC. Oregon is -106 to cover the spread, and USC is -114.

Oregon vs USC Over/Under

An over/under of 59.5 has been set for Oregon-USC on Nov. 22, with the over being -105 and the under -115.

Oregon vs USC Moneyline

The moneyline numbers for Oregon vs. USC reveal Oregon as the favorite (-420) and USC as the underdog (+330).

Oregon vs. USC Points Insights

Oregon vs. USC Game Info

• Game day: Saturday, November 22, 2025
• Game time: 3:30 p.m. ET
• TV channel: CBS
• Location: Eugene, Oregon
• Stadium: Autzen Stadium

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Check out even more in-depth Oregon vs. USC analysis on FanDuel Research.