Oklahoma vs Missouri Prediction, Odds, Picks, Best Bets for Week 13 2025

On Saturday in college football, the Oklahoma Sooners are playing the Missouri Tigers.

Before you make your wager on FanDuel Sportsbook, we've got you covered with all the latest NCAA football betting insights.

Oklahoma vs Missouri Odds & Spread

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• All college football odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: Oklahoma: (-215) | Missouri: (+180)
• Spread: Oklahoma: -5.5 (-110) | Missouri: +5.5 (-110)
• Total: 42.5 -- Over: (-115) | Under: (-105)

Oklahoma vs Missouri Betting Trends

• Oklahoma has six wins in 10 games against the spread this year.
• Oklahoma has won twice ATS (2-2) as a 5.5-point or bigger favorite this season.
• Oklahoma has had two games (out of 10) hit the over this year.
• Missouri is 6-4-0 against the spread this year.
• Missouri is winless ATS (0-1) when playing as at least 5.5-point underdogs this year.
• Missouri has seen six of its 10 games hit the over.

Oklahoma vs Missouri Prediction & Pick

All college football win probability predictions and picks are according to numberFire.
Prediction: Sooners win (75.2%)

Oklahoma vs Missouri Point Spread

Missouri is a 5.5-point underdog against Oklahoma. Missouri is -110 to cover the spread, and Oklahoma is -110.

Oklahoma vs Missouri Over/Under

Oklahoma versus Missouri on Nov. 22 has an over/under of 42.5 points, with the over -115 and the under -105.

Oklahoma vs Missouri Moneyline

The Oklahoma vs Missouri moneyline has Oklahoma as a -215 favorite, while Missouri is a +180 underdog.

Oklahoma vs. Missouri Points Insights

Oklahoma vs. Missouri Game Info

• Game day: Saturday, November 22, 2025
• Game time: 12 p.m. ET
• TV channel: ABC
• Location: Norman, Oklahoma
• Stadium: Gaylord Family Oklahoma Memorial Stadium

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Check out even more in-depth Oklahoma vs. Missouri analysis on FanDuel Research.