Oklahoma vs LSU Prediction, Odds, Picks, Best Bets for Week 14 2025

The Oklahoma Sooners will take on the LSU Tigers in college football action on Saturday.

Before you place your bet on this game at FanDuel Sportsbook, here are the NCAA football odds and spreads you need to know.

Oklahoma vs LSU Odds & Spread

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• All college football odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: Oklahoma: (-481) | LSU: (+370)
• Spread: Oklahoma: -10.5 (-115) | LSU: +10.5 (-105)
• Total: 35.5 -- Over: (-115) | Under: (-105)

Oklahoma vs LSU Betting Trends

• Oklahoma has covered the spread seven times in 11 games.
• As a 10.5-point or greater favorite, Oklahoma has one win ATS (1-2) this season.
• Two of 11 Oklahoma games have gone over the point total this year.
• LSU's record against the spread in 2025 is 3-8-0.
• LSU doesn't have a win ATS (0-1) as a 10.5-point underdog or greater this year.
• Of 11 LSU games so far this season, three have hit the over.

Oklahoma vs LSU Prediction & Pick

All college football win probability predictions and picks are according to numberFire.
Prediction: Sooners win (74.8%)

Oklahoma vs LSU Point Spread

LSU is listed as an underdog by 10.5 points (-105 odds), and Oklahoma, the favorite, is -115 to cover.

Oklahoma vs LSU Over/Under

Oklahoma versus LSU on Nov. 29 has an over/under of 35.5 points, with the over -115 and the under -105.

Oklahoma vs LSU Moneyline

Looking at the moneyline for Oklahoma-LSU, Oklahoma is the favorite at -481, and LSU is +370.

Oklahoma vs. LSU Points Insights

Oklahoma vs. LSU Game Info

• Game day: Saturday, November 29, 2025
• Game time: 3:30 p.m. ET
• TV channel: ABC
• Location: Norman, Oklahoma
• Stadium: Gaylord Family Oklahoma Memorial Stadium

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Check out even more in-depth Oklahoma vs. LSU analysis on FanDuel Research.