Ohio State vs USC Prediction, Odds, Picks, Best Bets for Week 9 2026

College football's Saturday schedule includes the Ohio State Buckeyes facing the USC Trojans.

Get the latest NCAA football odds ahead of this matchup on FanDuel Sportsbook.

Ohio State vs USC Odds & Spread

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• All college football odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: Ohio State: (-245) | USC: (+202)
• Spread: Ohio State: -6.5 (-122) | USC: +6.5 (100)
• Total: 51.5 -- Over: (-110) | Under: (-110)

Ohio State vs USC Betting Trends

• Against the spread, Ohio State is 5-2-0 this year.
• Ohio State's ATS record as 6.5-point or bigger favorites is 3-2.
• Ohio State has played seven games this season, and four of them have hit the over.
• USC owns two wins against the spread this year.
• USC has played eight games this year, and four of them have hit the over.

Ohio State vs USC Prediction & Pick

All college football win probability predictions and picks are according to numberFire.
Prediction: Buckeyes win (80.6%)

Ohio State vs USC Point Spread

Ohio State is favored by 6.5 points (-122 to cover) in this matchup. USC, the underdog, is +100.

Ohio State vs USC Over/Under

An over/under of 51.5 has been set for Ohio State-USC on Oct. 31, with the over being -110 and the under -110.

Ohio State vs USC Moneyline

Looking at the moneyline for Ohio State-USC, Ohio State is the favorite at -245, and USC is +202.

Ohio State vs. USC Points Insights

Ohio State vs. USC Game Info

• Game day: Saturday, October 31, 2026
• Game time: 7:30 p.m. ET
• TV channel: NBC
• Location: Los Angeles, California
• Stadium: Los Angeles Memorial Coliseum

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Check out even more in-depth Ohio State vs. USC analysis on FanDuel Research.