Ohio State vs Oregon Prediction, Odds, Picks, Best Bets for Week 10 2026

The Ohio State Buckeyes are among the college football squads busy on Saturday, versus the Oregon Ducks.

We've got you covered, in terms of the most important information regarding NCAA football betting lines, before you make your wager on FanDuel Sportsbook.

Ohio State vs Oregon Odds & Spread

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• All college football odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: Ohio State: (-285) | Oregon: (+230)
• Spread: Ohio State: -7.5 (-110) | Oregon: +7.5 (-110)
• Total: 45.5 -- Over: (-105) | Under: (-115)

Ohio State vs Oregon Betting Trends

• Against the spread, Ohio State is 5-3-0 this season.
• Ohio State's ATS record as 7.5-point or bigger favorites is 3-2.
• There have been four Ohio State games (of eight) that hit the over this season.
• Oregon has covered the spread three times in eight games.
• Oregon has played eight games this season, and five of them have gone over the total.

Ohio State vs Oregon Prediction & Pick

All college football win probability predictions and picks are according to numberFire.
Prediction: Buckeyes win (80.1%)

Ohio State vs Oregon Point Spread

Ohio State is favored by 7.5 points over Oregon. Ohio State is -110 to cover the spread, with Oregon being -110.

Ohio State vs Oregon Over/Under

The over/under for Ohio State-Oregon on Nov. 7 is 45.5. The over is -105, and the under is -115.

Ohio State vs Oregon Moneyline

The moneyline numbers for Ohio State vs. Oregon reveal Ohio State as the favorite (-285) and Oregon as the underdog (+230).

Ohio State vs. Oregon Points Insights

Ohio State vs. Oregon Game Info

• Game day: Saturday, November 7, 2026
• Game time: 3:30 p.m. ET
• TV channel: CBS
• Location: Columbus, Ohio
• Stadium: Ohio Stadium

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Check out even more in-depth Ohio State vs. Oregon analysis on FanDuel Research.