Ohio State vs Indiana Prediction, Odds, Picks, Best Bets for Big Ten Championship Game 2025

In college football action on Saturday, the Ohio State Buckeyes play the Indiana Hoosiers.

Before you make your wager on FanDuel Sportsbook, we've got you covered, in terms of the most important information regarding today's NCAA football betting odds.

Ohio State vs Indiana Odds & Spread

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• All college football odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: Ohio State: (-184) | Indiana: (+154)
• Spread: Ohio State: -4.5 (-105) | Indiana: +4.5 (-115)
• Total: 46.5 -- Over: (-114) | Under: (-106)

Ohio State vs Indiana Betting Trends

• Against the spread, Ohio State is 10-2-0 this year.
• As 4.5-point favorites or more, Ohio State is 9-2 against the spread.
• Out of 12 Ohio State games so far this year, four have gone over the total.
• Indiana's record against the spread in 2025 is 7-5-0.
• Indiana is unbeaten ATS (1-0) as a 4.5-point underdog or greater this season.
• Of 12 Indiana games so far this year, eight have gone over the total.

Ohio State vs Indiana Prediction & Pick

All college football win probability predictions and picks are according to numberFire.
Prediction: Buckeyes win (58%)

Ohio State vs Indiana Point Spread

Indiana is listed as an underdog by 4.5 points (-115 odds), and Ohio State, the favorite, is -105 to cover.

Ohio State vs Indiana Over/Under

The over/under for Ohio State-Indiana on Dec. 6 is 46.5. The over is -114, and the under is -106.

Ohio State vs Indiana Moneyline

Ohio State is the favorite, -184 on the moneyline, while Indiana is a +154 underdog.

Ohio State vs. Indiana Points Insights

Ohio State vs. Indiana Game Info

• Game day: Saturday, December 6, 2025
• Game time: 8 p.m. ET
• TV channel: FOX
• Location: Indianapolis, Indiana
• Stadium: Lucas Oil Stadium

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Check out even more in-depth Ohio State vs. Indiana analysis on FanDuel Research.