Notre Dame vs Pittsburgh Prediction, Odds, Picks, Best Bets for Week 12 2025

The Notre Dame Fighting Irish are among the college football teams busy on Saturday, up against the Pittsburgh Panthers.

Before you make your wager on FanDuel Sportsbook, we've got you covered with all the latest NCAA football betting insights.

Notre Dame vs Pittsburgh Odds & Spread

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• All college football odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: Notre Dame: (-481) | Pittsburgh: (+360)
• Spread: Notre Dame: -12.5 (-105) | Pittsburgh: +12.5 (-115)
• Total: 53.5 -- Over: (-114) | Under: (-106)

Notre Dame vs Pittsburgh Betting Trends

• Notre Dame has four wins in nine games against the spread this year.
• Notre Dame's ATS record as 12.5-point or bigger favorites is 3-2.
• There have been five Notre Dame games (of nine) that hit the over this season.
• Pittsburgh is 7-2-0 against the spread this season.
• Pittsburgh has seen seven of its nine games hit the over.

Notre Dame vs Pittsburgh Prediction & Pick

All college football win probability predictions and picks are according to numberFire.
Prediction: Fighting Irish win (77.7%)

Notre Dame vs Pittsburgh Point Spread

Notre Dame is a 12.5-point favorite against Pittsburgh. Notre Dame is -105 to cover the spread, and Pittsburgh is -115.

Notre Dame vs Pittsburgh Over/Under

A total of 53.5 points has been set for the Notre Dame-Pittsburgh matchup on Nov. 15, with the over available at -114 and the under at -106.

Notre Dame vs Pittsburgh Moneyline

Pittsburgh is the underdog, +360 on the moneyline, while Notre Dame is a -481 favorite.

Notre Dame vs. Pittsburgh Points Insights

Notre Dame vs. Pittsburgh Game Info

• Game day: Saturday, November 15, 2025
• Game time: 12 p.m. ET
• TV channel: ABC
• Location: Pittsburgh, Pennsylvania
• Stadium: Acrisure Stadium

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Check out even more in-depth Notre Dame vs. Pittsburgh analysis on FanDuel Research.