Notre Dame vs Louisville Prediction, Odds, & Betting Trends for College Football Week 6 Game

In college football action on Saturday, the Notre Dame Fighting Irish take on the Louisville Cardinals.

We've got you covered, in terms of the most important information about NCAA football betting lines, before you make your wager on FanDuel Sportsbook.

Notre Dame vs Louisville Odds & Spread

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• All college football odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: Notre Dame: (-255) | Louisville: (+205)
• Spread: Notre Dame: -6.5 (-110) | Louisville: +6.5 (-110)
• Total: 53.5 -- Over: (-110) | Under: (-110)

Notre Dame vs Louisville Betting Trends

• Notre Dame's record against the spread is 5-1-0.
• Notre Dame owns an ATS record of 3-1 as 6.5-point or greater favorites.
• This year, three of Notre Dame's six games have hit the over.
• Louisville has posted two wins against the spread this year.
• A pair of Louisville five games in 2023 have gone over the point total.

Notre Dame vs Louisville Prediction & Pick

All college football win probability predictions and picks are according to numberFire.
Prediction: Fighting Irish win (73.6%)

Notre Dame vs Louisville Point Spread

Notre Dame is favored by 6.5 points over Louisville. Notre Dame is -110 to cover the spread, with Louisville being -110.

Notre Dame vs Louisville Over/Under

The over/under for the Notre Dame versus Louisville matchup on October 7 has been set at 53.5, with -110 odds on the over and -110 odds on the under.

Notre Dame vs Louisville Moneyline

Notre Dame is the favorite, -255 on the moneyline, while Louisville is a +205 underdog.

Notre Dame vs. Louisville Points Insights

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Check out even more in-depth Notre Dame vs. Louisville analysis on FanDuel Research.