The Buffalo Bills versus the Detroit Lions is one of many compelling options on the Week 15 NFL Sunday schedule.

Check out our betting preview for the NFL's Week 15 action on Sunday.

Jaguars vs. Jets

Star pass-catcher Brian Thomas Jr. will lead the Jacksonville Jaguars into their battle versus the New York Jets at EverBank Stadium on Sunday at 1 p.m. ET.

• Matchup: New York Jets at Jacksonville Jaguars
• Projected Favorite: Jets (53.12% win probability)
• Spread: New York (-3.5)
• Total: 40.5 -- Over: (-108) | Under: (-112)
• Time: 1 p.m. ET
• Channel: FOX

Bet on Jacksonville vs. New York with FanDuel Sportsbook.

Giants vs. Ravens

Against the New York Giants (2-11), who own the 29th-ranked run defense this season, Derrick Henry and the Baltimore Ravens (8-5) should have success running the ball when the two teams meet on Sunday, Dec. 15 at 1 p.m. ET. Henry has been one of the NFL's top rushers this year, ranking second-best in the league in rushing yards.

• Matchup: Baltimore Ravens at New York Giants
• Projected Favorite: Ravens (78.39% win probability)
• Spread: Baltimore (-16.5)
• Total: 42.5 -- Over: (-110) | Under: (-110)
• Time: 1 p.m. ET
• Channel: CBS

Bet on New York vs. Baltimore with FanDuel Sportsbook.

Browns vs. Chiefs

The Kansas City Chiefs (12-1), who took down the Chargers in their last game, visit the Cleveland Browns (3-10) at Cleveland Browns Stadium on Dec. 15 at 1 p.m. ET. The Browns were defeated by the Steelers in their last game.

• Matchup: Kansas City Chiefs at Cleveland Browns
• Projected Favorite: Chiefs (66.39% win probability)
• Spread: Kansas City (-4.5)
• Total: 42.5 -- Over: (-105) | Under: (-115)
• Time: 1 p.m. ET
• Channel: CBS

Bet on Cleveland vs. Kansas City with FanDuel Sportsbook.

Titans vs. Bengals

The 1 p.m. ET game on Dec. 15 between the Cincinnati Bengals (5-8) and the Tennessee Titans (3-10) should be a fun matchup, as Joe Burrow has been one of the NFL's top passers this season, and the Titans have a top-five pass defense, ranking first in the NFL at 175.5 passing yards surrendered per contest.

• Matchup: Cincinnati Bengals at Tennessee Titans
• Projected Favorite: Bengals (55.24% win probability)
• Spread: Cincinnati (-4.5)
• Total: 46.5 -- Over: (-105) | Under: (-115)
• Time: 1 p.m. ET
• Channel: FOX

Bet on Tennessee vs. Cincinnati with FanDuel Sportsbook.

Texans vs. Dolphins

One of the top running backs in football will be on display when Joe Mixon and the Houston Texans host the Miami Dolphins on Sunday, December 15, 2024.

• Matchup: Miami Dolphins at Houston Texans
• Projected Favorite: Texans (64.27% win probability)
• Spread: Houston (-2.5)
• Total: 46.5 -- Over: (-105) | Under: (-115)
• Time: 1 p.m. ET
• Channel: CBS

Bet on Houston vs. Miami with FanDuel Sportsbook.

Panthers vs. Cowboys

At 1 p.m. ET on Dec. 15, the Carolina Panthers (3-10) and their bottom-five (28th in NFL) scoring offense will square off against the Dallas Cowboys (5-8) and their bottom-five (31st) scoring defense at Bank of America Stadium.

• Matchup: Dallas Cowboys at Carolina Panthers
• Projected Favorite: Panthers (56.00% win probability)
• Spread: Carolina (-2.5)
• Total: 42.5 -- Over: (-120) | Under: (-102)
• Time: 1 p.m. ET
• Channel: FOX

Bet on Carolina vs. Dallas with FanDuel Sportsbook.

Saints vs. Commanders

The New Orleans Saints (5-8) and Alvin Kamara, one of the league's top rushers, should have a big day running the ball on Sunday, as the Washington Commanders (8-5) have the 28th-ranked run defense in the league. The two teams will collide at 1 p.m. ET on Dec. 15.

• Matchup: Washington Commanders at New Orleans Saints
• Projected Favorite: Commanders (67.75% win probability)
• Spread: Washington (-7.5)
• Total: 43.5 -- Over: (-114) | Under: (-106)
• Time: 1 p.m. ET
• Channel: FOX

Bet on New Orleans vs. Washington with FanDuel Sportsbook.

Lions vs. Bills

The Detroit Lions host the Buffalo Bills on Sunday at 4:25 p.m. ET, in a matchup between two of the top offensive players in football in wide receiver Amon-Ra St. Brown and quarterback Josh Allen.

• Matchup: Buffalo Bills at Detroit Lions
• Projected Favorite: Lions (62.64% win probability)
• Spread: Detroit (-2.5)
• Total: 54.5 -- Over: (-110) | Under: (-110)
• Time: 4:25 p.m. ET
• Channel: CBS

Bet on Detroit vs. Buffalo with FanDuel Sportsbook.

Broncos vs. Colts

The Indianapolis Colts are in action on Sunday at 4:25 p.m. ET at Empower Field at Mile High against the Denver Broncos.

• Matchup: Indianapolis Colts at Denver Broncos
• Projected Favorite: Broncos (67.08% win probability)
• Spread: Denver (-3.5)
• Total: 44.5 -- Over: (-104) | Under: (-118)
• Time: 4:25 p.m. ET
• Channel: CBS

Bet on Denver vs. Indianapolis with FanDuel Sportsbook.

Cardinals vs. Patriots

After going down 30-18 to the Seahawks in their last tilt, the Arizona Cardinals (6-7) will host the New England Patriots (3-10), who are coming off a 25-24 loss to the Colts, at State Farm Stadium. The game is scheduled for 4:25 p.m. ET on Sunday, Dec. 15.

• Matchup: New England Patriots at Arizona Cardinals
• Projected Favorite: Cardinals (72.67% win probability)
• Spread: Arizona (-6.5)
• Total: 46.5 -- Over: (-104) | Under: (-118)
• Time: 4:25 p.m. ET
• Channel: CBS

Bet on Arizona vs. New England with FanDuel Sportsbook.

Chargers vs. Buccaneers

The Tampa Bay Buccaneers (7-6), who sport the fifth-ranked scoring offense in the league, will have to be at the top of their game when they visit the Los Angeles Chargers (8-5) and their stout defense, which is No. 1 in the NFL. Kickoff is slated for 4:25 p.m. ET on Sunday, Dec. 15.

• Matchup: Tampa Bay Buccaneers at Los Angeles Chargers
• Projected Favorite: Chargers (52.35% win probability)
• Spread: Los Angeles (-3)
• Total: 45.5 -- Over: (-105) | Under: (-115)
• Time: 4:25 p.m. ET
• Channel: FOX

Bet on Los Angeles vs. Tampa Bay with FanDuel Sportsbook.

Eagles vs. Steelers

Saquon Barkley will lead the Philadelphia Eagles into their matchup versus the Pittsburgh Steelers at Lincoln Financial Field on Sunday at 4:25 p.m. ET.

• Matchup: Pittsburgh Steelers at Philadelphia Eagles
• Projected Favorite: Eagles (70.15% win probability)
• Spread: Philadelphia (-5.5)
• Total: 42.5 -- Over: (-115) | Under: (-105)
• Time: 4:25 p.m. ET
• Channel: FOX

Bet on Philadelphia vs. Pittsburgh with FanDuel Sportsbook.

Seahawks vs. Packers

The Green Bay Packers (9-4) are set to collide with the Seattle Seahawks (8-5) at Lumen Field on Sunday, Dec. 15 at 8:20 p.m. ET. In their last games, the Packers were defeated by the Lions 34-31, and the Seahawks won 30-18 against the Cardinals.

• Matchup: Green Bay Packers at Seattle Seahawks
• Projected Favorite: Packers (51.69% win probability)
• Spread: Green Bay (-2.5)
• Total: 46.5 -- Over: (-105) | Under: (-115)
• Time: 8:20 p.m. ET
• Channel: NBC

Bet on Seattle vs. Green Bay with FanDuel Sportsbook.

Matchup favorites and win projections are provided by numberFire.

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