NFL DFS Picks for Week 10: Best FanDuel Plays for This Week

Week 10 NFL DFS Picks in Summary

• Christian McCaffrey (RB) — $9,000
• CeeDee Lamb (WR) — $9,000
• Drew Lock (QB) — $7,000

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Part of the beauty of NFL DFS on FanDuel is that the slate changes — sometimes drastically — from week to week.

Using our NFL DFS projections as a guide, let's take a look at some of the best daily fantasy football plays at each position — accounting for salary — on this week's FanDuel main slate.

Note: All stats come from NextGenStats or Pro Football Focus unless stated otherwise.

NFL DFS Week 10: Best Picks, Plays for FanDuel

Christian McCaffrey (RB) — $9,000

49ers at Cowboys — 4:25 p.m. ET

Christian McCaffrey has logged 102 carries for 457 yards and nine rushing touchdowns through Week 9, and his 36 receptions add another valuable scoring path in FanDuel’s half-PPR format. He handled 20 touches against Las Vegas last Sunday, producing 68 rushing yards, 19 receiving yards and two total touchdowns. That kind of multi-phase role helps him retain a strong ceiling even in games when his yards per carry are ordinary. This week, CMC plays in the best DFS game environment on the slate as the San Francisco 49ers-Dallas Cowboys matchup holds a slate-high 55.5-point total.

CeeDee Lamb (WR) — $9,000

49ers at Cowboys — 4:25 p.m. ET

On the other end of the Niners-Cowboys clash, CeeDee Lamb is a great game-stacking piece to pair with CMC. Lamb has already amassed 108 targets, 70 catches, 904 receiving yards and seven touchdowns over nine games. He erupted for 10 receptions, 195 yards and a score on 16 targets against Indianapolis in Week 9, and he has earned double-digit targets in four consecutive games. San Fran is a quality defense, but this game’s shootout potential gives Lamb huge upside.

Brock Purdy (QB) — $8,700

49ers at Cowboys — 4:25 p.m. ET

One more piece from the 49ers-Cowboys game. Brock Purdy has completed 69.1% of his passes for 1,980 yards and 17 touchdowns through eight appearances, averaging 8.4 yards per attempt. In Week 9, he added 40 rushing yards and a touchdown to 232 passing yards and two passing scores, underscoring that his legs can provide an extra route to a big fantasy score. We can’t just take all the high-salary options from this game, but Purdy against a bad Dallas D is my favorite QB play this week.

Chris Olave (WR) — $7,900

Panthers at Saints — 1:00 p.m. ET

Chris Olave enters Week 10 with 83 targets, 56 receptions and 734 receiving yards in eight appearances — good for 10.4 targets and 91.8 yards per game. He most recently drew 12 targets and turned seven catches into 98 yards against Cleveland, continuing to operate as the central figure in the New Orleans Saints’ passing attack. The Carolina Panthers are short-handed in the secondary and provide a friendly matchup. Olave offers a strong combination of target-driven floor and big-play upside at $7,900.

Drew Lock (QB) — $7,000

Seahawks at Raiders — 4:05 p.m. ET

At a salary of just $7,000, Drew Lock is a solid value play for Sunday's main slate. Lock has completed 71.1% of his passes this season while averaging 7.9 yards per attempt and producing five touchdowns without an interception. He draws a favorable matchup against the Las Vegas Raiders, who have surrendered 19.9 fantasy points per game to opposing quarterbacks, the sixth-most in the league. With Jaxon Smith-Njigba at his disposal, Lock has the weapons to take advantage of this matchup and deliver a strong return on his modest salary, provided his elbow injury doesn't prevent him from playing.

Kyle Pitts Sr. (TE) — $5,100

Chiefs at Falcons — 1:00 p.m. ET

Kyle Pitts Sr. has averaged a 15% team target share and 4.1 targets per game through nine weeks, with an average snap share of 59%. While his involvement has fluctuated, Pitts has seen at least five targets in each of his past five games. At $5,100, his appeal is mostly salary relief and touchdown upside rather than a reliably high receiving-yardage floor. Against the Kansas City Chiefs in a game where the Atlanta Falcons may have to go to the air to keep pace, Pitts is on the value radar.

What are this week’s best NFL player props?

NFL DFS FAQ

What are the best NFL DFS plays each week?

The best NFL DFS plays can change from week to week based on salary, matchup, expected workload, injuries, projected popularity and game environment. Players with strong opportunities and favorable salaries can offer the best combination of floor and upside.

How do you choose NFL DFS plays?

NFL DFS plays are evaluated using factors such as projected volume, recent production, matchup, touchdown potential, expected popularity, game script and salary. Injuries and changes in player roles can also create new opportunities each week.

What is an NFL DFS value play?

An NFL DFS value play is a player who has the potential to produce strong fantasy numbers relative to his salary. Lower-salaried players can become particularly appealing when injuries or other circumstances lead to increased playing time or usage.

What makes a good NFL DFS lineup?

Matchups, expected volume, salary, lineup correlation, projected draft percentage and game environment are all important factors when building a lineup. You’ll need upside to take down a contest.

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The above author is a FanDuel employee and is not eligible to compete in public daily fantasy contests or place sports betting wagers on FanDuel. The advice provided by the author does not necessarily represent the views of FanDuel. Taking the author's advice will not guarantee a successful outcome. You should use your own judgment when participating in daily fantasy contests or placing sports wagers.