Nationals vs Giants Prediction, Odds, Moneyline, Spread & Over/Under for May 23

Odds updated as of 7:12 a.m.

The Friday schedule in MLB includes a matchup between the Washington Nationals and the San Francisco Giants.

We've got you covered, in terms of the most important information regarding this matchup before you take a look at the MLB odds and spreads on FanDuel Sportsbook.

Nationals vs Giants Game Info

• Washington Nationals (23-27) vs. San Francisco Giants (29-21)
• Date: Friday, May 23, 2025
• Time: 6:45 p.m. ET
• Venue: Nationals Park -- Washington, District of Columbia
• Coverage: MASN2 and NBCS-BA

Nationals vs Giants Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: WSH: (-110) | SF: (-106)
• Spread: WSH: +1.5 (-178) | SF: -1.5 (+146)
• Total: 8 -- Over: (-105) | Under: (-115)

Nationals vs Giants Probable Starting Pitchers

Probable Pitchers: MacKenzie Gore (Nationals) - 2-4, 3.67 ERA vs Landen Roupp (Giants) - 2-3, 4.30 ERA

The probable starters are MacKenzie Gore (2-4) for the Nationals and Landen Roupp (2-3) for the Giants. Gore's team is 4-6-0 against the spread this season in his starts. Gore's team is 1-4 this season when he starts and they are the moneyline favorite. When Roupp starts, the Giants have gone 3-6-0 against the spread. The Giants have been the underdog on the moneyline in five of Roupp's starts this season, and they went 2-3 in those matchups.

Nationals vs Giants Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Nationals win (50.6%)

Nationals vs Giants Moneyline

• Washington is a -110 favorite on the moneyline, while San Francisco is a -106 underdog on the road.

Nationals vs Giants Spread

• The Giants are 1.5-run favorites against the spread for this matchup with the Nationals. The Giants are +146 to cover, while the Nationals are -178 to cover as a 1.5-run underdog on the runline.

Nationals vs Giants Over/Under

• A combined run total of 8 has been set for Nationals-Giants on May 23, with the over at -105 and the under at -115.

Bet on Washington Nationals vs. San Francisco Giants on FanDuel today!

Nationals vs Giants Betting Trends

• The Nationals have come away with two wins in the seven contests they have been listed as the favorites in this season.
• Washington has a record of 2-5 in contests when bookmakers favor them by -110 or more on the moneyline.
• Contests with the Nationals have gone over the total set by oddsmakers in 24 of 48 chances this season.
• In 48 games with a line this season, the Nationals have a mark of 26-22-0 against the spread.
• The Giants are 9-9 in games they were the underdog on the moneyline (winning 50% of those games).
• San Francisco has a 9-9 record (winning 50% of its games) when it has played as a moneyline underdog of -106 or longer.
• The Giants have combined with opponents to go over the total 27 times this season for a 27-22-1 record against the over/under.
• The Giants have a 24-26-0 record against the spread this season (covering 48% of the time).

Nationals Player Leaders

• James Wood leads Washington with an OBP of .389, plus a team-best slugging percentage of .545. He's batting .291 on the season.
• He ranks 27th in batting average, 14th in on-base percentage, and 13th in slugging among qualifying hitters in baseball.
• Wood has hit safely in five games in a row. During his last five outings he is hitting .529 with a double, a home run, five walks and eight RBIs.
• C.J. Abrams leads Washington with 46 hits. He is batting .311 this season and has 19 extra-base hits. He's also slugging .561 with an on-base percentage of .372.
• He ranks ninth in batting average, 29th in on-base percentage and seventh in slugging among qualified hitters.
• Abrams heads into this game looking to extend his four-game hit streak. During his last five outings he is hitting .273 with two doubles, two home runs, a walk and three RBIs.
• Nathaniel Lowe has 42 hits this season and has a slash line of .222/.295/.392.
• Lowe heads into this game with two games in a row with at least one hit. In his last five games he is batting .190 with a double, a home run, a walk and four RBIs.
• Keibert Ruiz has two home runs, 20 RBI and a batting average of .283 this season.
• Ruiz has safely hit in four games in a row. During his last five outings he is hitting .273 with three doubles and six RBIs.

Giants Player Leaders

• Jung Hoo Lee has 14 doubles, two triples, six home runs and 13 walks while batting .276. He's slugging .464 with an on-base percentage of .322.
• He is 53rd in batting average, 89th in on-base percentage and 52nd in slugging percentage among all qualifying hitters in MLB.
• Lee takes a three-game hitting streak into this game. During his last five outings he is hitting .158 with two doubles, two walks and two RBIs.
• Heliot Ramos paces his team with 55 hits and has a club-high .500 slugging percentage. He has a batting average of .296 with an on-base percentage of .362.
• Including all qualifying players, he ranks 23rd in batting average, 40th in on-base percentage and 29th in slugging percentage.
• Wilmer Flores has two doubles, 10 home runs and 16 walks while batting .257.
• Matt Chapman has seven doubles, nine home runs and 32 walks while batting .217.

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