Mississippi State vs Southern Miss Prediction, Odds, Picks, Best Bets for Week 1 2025

On Saturday in college football, the Mississippi State Bulldogs are playing the Southern Miss Golden Eagles.

Get the latest NCAA football odds ahead of this game on FanDuel Sportsbook.

Mississippi State vs Southern Miss Odds & Spread

Sign up for FanDuel Sportsbook and FanDuel Daily Fantasy today!

• All college football odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: Mississippi State: (-549) | Southern Miss: (+400)
• Spread: Mississippi State: -12.5 (-122) | Southern Miss: +12.5 (100)
• Total: 60.5 -- Over: (-115) | Under: (-105)

Mississippi State vs Southern Miss Betting Trends

• Mississippi State's record against the spread last year was 7-5-0.
• Mississippi State did not lose ATS (2-0) as a 12.5-point or greater favorite last season.
• Last season, eight of Mississippi State's 12 games went over the point total.
• Southern Miss had four wins in 12 games against the spread last year.
• Southern Miss' ATS record as an underdog of 12.5 points or more was 3-5 last year.
• Southern Miss had five of its 12 games hit the over last year.

Mississippi State vs Southern Miss Prediction & Pick

All college football win probability predictions and picks are according to numberFire.
Prediction: Bulldogs win (84.8%)

Mississippi State vs Southern Miss Point Spread

Mississippi State is favored by 12.5 points against Southern Miss. Mississippi State is -122 to cover the spread, while Southern Miss is +100.

Mississippi State vs Southern Miss Over/Under

An over/under of 60.5 has been set for Mississippi State-Southern Miss on Aug. 30, with the over being -115 and the under -105.

Mississippi State vs Southern Miss Moneyline

Looking at the moneyline for Southern Miss-Mississippi State, Southern Miss is the underdog at +400, and Mississippi State is -549.

Mississippi State vs. Southern Miss Points Insights

• The Bulldogs' average implied point total last season was 1.7 more points than their implied total in Saturday's game (38.7 implied points on average compared to 37 implied points in this game).
• The average implied point total last season for the Golden Eagles (35.3) is 11.3 more points than the team's implied total in this matchup (24).

Mississippi State vs. Southern Miss Game Info

• Game day: Saturday, August 30, 2025
• Game time: 12 p.m. ET
• TV channel: ESPN
• Location: Hattiesburg, Mississippi
• Stadium: M.M. Roberts Stadium

Sign up for FanDuel Sportsbook and FanDuel Daily Fantasy today!

Check out even more in-depth Mississippi State vs. Southern Miss analysis on FanDuel Research.