Michigan State vs Ole Miss Basketball Prediction, Odds, Picks, Best Bets for NCAA Tournament Sweet 16

A Sweet 16 NCAA Tournament matchup features the No. 2 Michigan State Spartans (29-6) and No. 6 Ole Miss Rebels (24-11) to decide which of the squads is heading to the South regional final when it tips off on Friday at State Farm Arena, beginning at 7:09 p.m. ET, airing on CBS.

Before you place your bet on this game at FanDuel Sportsbook, here are the NCAA basketball odds and spreads you need to know.

Michigan State vs. Ole Miss Game Info and Odds

• Game day: Friday, March 28, 2025
• Game time: 7:09 p.m. ET
• TV channel: CBS
• Location: Atlanta, Georgia
• Arena: State Farm Arena

Michigan State vs. Ole Miss Picks and Prediction

All college basketball win probability predictions and picks are according to numberFire.
Prediction: Michigan State win (61.1%)

See the betting insights and trends below before making a wager on Friday's Michigan State-Ole Miss spread (Michigan State -3.5) or total (144.5 points).

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Michigan State vs. Ole Miss: ATS Betting Stats and Trends

• Michigan State has covered 24 times in 35 chances against the spread this season.
• Ole Miss has won 18 games against the spread this year, while failing to cover 17 times.
• As a 3.5-point favorite or more in 2024-25, Michigan State is 18-6 against the spread compared to the 7-4 ATS record Ole Miss puts up as a 3.5-point underdog.
• When playing at home, the Spartans own a worse record against the spread (10-6-0) compared to their ATS record on the road (7-2-0).
• The Rebels have performed better against the spread at home (7-9-0) than away (4-7-0) this year.

Michigan State vs. Ole Miss: Moneyline Betting Stats

• Michigan State has been victorious in 24, or 85.7%, of the 28 contests it has been chosen as moneyline favorites in this season.
• This year, the Spartans have won 21 of 23 games when listed as at least -164 or better on the moneyline.
• Ole Miss has a 7-9 record in games it was listed as the moneyline underdog (winning 43.8% of those games).
• The Rebels have a record of 2-6 when playing as a moneyline underdog with odds of +136 or longer (25%).
• Michigan State has an implied victory probability of 62.1% according to the moneyline set for this matchup.

Michigan State vs. Ole Miss Head-to-Head Comparison

• Michigan State's +393 scoring differential (outscoring opponents by 11.2 points per game) is a result of scoring 78.2 points per game (74th in college basketball) while giving up 67 per outing (43rd in college basketball).
• Jaden Akins' 12.7 points per game lead Michigan State and rank 575th in the nation.
• Ole Miss' +200 scoring differential (outscoring opponents by 5.7 points per game) is a result of putting up 77.4 points per game (82nd in college basketball) while allowing 71.7 per contest (172nd in college basketball).
• Sean Pedulla's 15.2 points per game paces Ole Miss and ranks 244th in the country.
• The Spartans win the rebound battle by an average of nine boards. They are recording 37 rebounds per game (seventh in college basketball) compared to their opponents' 28 per contest.
• Jaxon Kohler's 7.5 rebounds per game lead the Spartans and rank 104th in college basketball play.
• The Rebels lose the rebound battle by 3.6 boards on average. They collect 29.8 rebounds per game, 307th in college basketball, while their opponents pull down 33.4.
• Malik Dia averages 5.7 rebounds per game (396th in college basketball) to lead the Rebels.
• Michigan State ranks 68th in college basketball by averaging 100.6 points per 100 possessions on offense, and defensively is 21st in college basketball, allowing 86.1 points per 100 possessions.
• The Rebels rank 80th in college basketball with 99.8 points scored per 100 possessions, and 149th defensively with 92.4 points conceded per 100 possessions.

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