Mariners vs Guardians Prediction, Odds, Moneyline, Spread & Over/Under for March 28

Odds updated as of 5:12 a.m.

Saturday's slate in the MLB includes a matchup between the Seattle Mariners and the Cleveland Guardians.

Here's everything you need to know before checking out today's MLB odds and spreads on FanDuel Sportsbook.

Mariners vs Guardians Game Info

• Seattle Mariners (1-1) vs. Cleveland Guardians (1-1)
• Date: Saturday, March 28, 2026
• Time: 9:40 p.m. ET
• Venue: T-Mobile Park -- Seattle, Washington
• Coverage: Mariners.TV and CleGuardians.TV

Mariners vs Guardians Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: SEA: (-180) | CLE: (+152)
• Spread: SEA: -1.5 (+120) | CLE: +1.5 (-144)
• Total: 7 -- Over: (-112) | Under: (-108)

Mariners vs Guardians Probable Starting Pitchers

Probable Pitchers: Bryan Woo (Mariners) - 0-0, 0.00 ERA vs Joey Cantillo (Guardians) - 0-0, 0.00 ERA

The Mariners will call on Bryan Woo versus the Guardians and Joey Cantillo. Woo and his team were 13-17-0 against the spread when he pitched last season. Woo and his team won 56.5% of the games he started as the moneyline favorite last season, with a record of 13-10. Last season when Cantillo pitched his team went 7-6-0 against the spread. Cantillo and his team finished 3-2 in the five games he appeared in when they were moneyline underdogs a season ago.

Mariners vs Guardians Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Mariners win (66.8%)

Mariners vs Guardians Moneyline

• Cleveland is a +152 underdog on the moneyline, while Seattle is a -180 favorite at home.

Mariners vs Guardians Spread

• The Mariners are hosting the Guardians and are favored by 1.5 runs (+120 to cover) on the runline. Cleveland is -144 to cover.

Mariners vs Guardians Over/Under

• The over/under for Mariners-Guardians on March 28 is 7. The over is -112, and the under is -108.

Bet on Seattle Mariners vs. Cleveland Guardians on FanDuel today!

Mariners vs Guardians Betting Trends

• The Mariners came away with 66 wins in the 114 contests they were listed as the favorites last season.
• Last year, Seattle won 21 of 25 games when listed as at least -180 on the moneyline.
• The Mariners and their opponents hit the over in 91 of their 168 games with a total last season.
• The Guardians compiled a 41-47 record in games last season when they were the underdog on the moneyline (winning 46.6% of those games).
• When it played as a moneyline underdog with odds of +152 or longer last year, Cleveland went 4-8 (33.3%).
• The Guardians combined with their opponents to go over the total 69 times last season for a 69-85-7 record against the over/under.

Mariners Player Leaders

• Cal Raleigh had 147 hits and an OBP of .359 last season.
• Julio Rodriguez had an OPS of .798, fueled by an OBP of .324 and a slugging percentage of .474.
• Last season, Josh Naylor finished with 20 home runs, 92 RBI and a batting average of .295 last season.
• Randy Arozarena slashed .238/.334/.426 and finished with an OPS of .760.

Guardians Player Leaders

• Jose Ramirez racked up an OBP of .360 with 168 hits last season.
• Steven Kwan slugged .374 while batting .272.
• Kyle Manzardo hit .234 with 19 doubles, two triples, 27 home runs and 48 walks a season ago.
• Angel Martinez hit .224 with 23 doubles, two triples, 11 home runs and 23 walks.

Mariners vs Guardians Head to Head

• 3/27/2026: 5-1 SEA (Favorite: Mariners, Spread: -1.5, Total: 7, Favorite Moneyline: -178, Underdog Moneyline: +150)
• 3/26/2026: 6-4 CLE (Favorite: Mariners, Spread: -1.5, Total: 6.5, Favorite Moneyline: -188, Underdog Moneyline: +158)
• 8/31/2025: 4-2 SEA (Favorite: Mariners, Spread: -1.5, Total: 8, Favorite Moneyline: -116, Underdog Moneyline: -102)
• 8/30/2025: 4-3 CLE (Favorite: Mariners, Spread: -1.5, Total: 7.5, Favorite Moneyline: -154, Underdog Moneyline: +130)
• 8/29/2025: 5-4 CLE (Favorite: Mariners, Spread: -1.5, Total: 7.5, Favorite Moneyline: -162, Underdog Moneyline: +136)
• 6/15/2025: 6-0 SEA (Favorite: Mariners, Spread: -1.5, Total: 8, Favorite Moneyline: -124, Underdog Moneyline: +106)
• 6/14/2025: 4-3 SEA (Favorite: Mariners, Spread: -1.5, Total: 7, Favorite Moneyline: -136, Underdog Moneyline: +116)
• 6/13/2025: 7-2 SEA (Favorite: Mariners, Spread: -1.5, Total: 7.5, Favorite Moneyline: -112, Underdog Moneyline: -104)
• 6/20/2024: 6-3 CLE (Favorite: Guardians, Spread: -1.5, Total: 8, Favorite Moneyline: -126, Underdog Moneyline: +108)
• 6/19/2024: 8-0 CLE (Favorite: Guardians, Spread: -1.5, Total: 7.5, Favorite Moneyline: -156, Underdog Moneyline: +132)

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