Mariners vs Cardinals Prediction, Odds, Moneyline, Spread & Over/Under for April 25

Odds updated as of 10:11 p.m.

In MLB action on Saturday, the Seattle Mariners face the St. Louis Cardinals.

We've got you covered, in terms of the most important information regarding this matchup before you take a look at the MLB odds and spreads on FanDuel Sportsbook.

Mariners vs Cardinals Game Info

• Seattle Mariners (11-15) vs. St. Louis Cardinals (14-10)
• Date: Saturday, April 25, 2026
• Time: 2:15 p.m. ET
• Venue: Busch Stadium -- St. Louis, Missouri
• Coverage: Cardinals.TV and Mariners.TV

Mariners vs Cardinals Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: SEA: (-154) | STL: (+130)
• Spread: SEA: -1.5 (+114) | STL: +1.5 (-137)
• Total: 7.5 -- Over: (-122) | Under: (+100)

Mariners vs Cardinals Probable Starting Pitchers

Probable Pitchers: Bryan Woo (Mariners) - 1-2, 2.25 ERA vs Matthew Liberatore (Cardinals) - 0-1, 3.67 ERA

The Mariners will give the ball to Bryan Woo (1-2, 2.25 ERA), who is eyeing win No. 2 on the season, and the Cardinals will turn to Matthew Liberatore (0-1, 3.67 ERA). Woo's team is 2-3-0 against the spread this season in his starts. Woo's team has been victorious in 40% of the games he's started as the moneyline favorite with a record of 2-3. When Liberatore starts, the Cardinals have gone 3-2-0 against the spread. The Cardinals are 4-1 in Liberatore's five starts this season that they were the underdog on the moneyline.

Mariners vs Cardinals Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Mariners win (58.6%)

Mariners vs Cardinals Moneyline

• Seattle is a -154 favorite on the moneyline, while St. Louis is a +130 underdog at home.

Mariners vs Cardinals Spread

• The Mariners are 1.5-run road favorites on the runline against the Cardinals. The Mariners are +114 to cover, and the Cardinals are -137.

Mariners vs Cardinals Over/Under

• The Mariners-Cardinals game on April 25 has been given an over/under of 7.5 runs. The over is set at -122 and the under at +100.

Bet on Seattle Mariners vs. St. Louis Cardinals on FanDuel today!

Mariners vs Cardinals Betting Trends

• The Mariners have been chosen as favorites in 22 games this year and have walked away with the win 10 times (45.5%) in those games.
• This season Seattle has been victorious five times in 10 chances when named as a favorite of at least -154 on the moneyline.
• The Mariners and their opponents have hit the over in 12 of their 26 games with a total set by oddsmakers this season.
• The Mariners have an against the spread record of 9-17-0 in 26 games with a line this season.
• The Cardinals have compiled a 12-9 record in games they were listed as the moneyline underdog (winning 57.1% of those games).
• St. Louis is 1-2 (winning just 33.3% of its games) when it has played as a moneyline underdog of +130 or longer.
• In the 24 games bookmakers have set an over/under for the Cardinals, they have combined with opponents to go over the total 13 times (13-10-1).
• The Cardinals are 13-11-0 against the spread this season.

Mariners Player Leaders

• Randy Arozarena leads Seattle with 27 hits and an OBP of .385, plus a team-best slugging percentage of .419. He's batting .290.
• Among qualifying hitters in the majors, he ranks 32nd in batting average, 21st in on-base percentage, and 80th in slugging.
• Arozarena has hit safely in two games in a row. In his last five games he is batting .316 with two doubles, a home run and three RBIs.
• Cole Young is hitting .233 with two doubles, a triple, two home runs and 11 walks. He's slugging .344 with an on-base percentage of .324.
• He ranks 117th in batting average, 104th in on-base percentage and 134th in slugging among qualified hitters.
• Cal Raleigh is batting .198 with a .386 slugging percentage and 14 RBI this year.
• Raleigh enters this matchup with four games in a row with at least one hit. During his last five outings he is hitting .333 with a double, three home runs, two walks and three RBIs.
• Luke Raley has five home runs, 13 RBI and a batting average of .292 this season.

Cardinals Player Leaders

• Jordan Walker has accumulated a team-high slugging percentage (.607) while leading the Cardinals in hits (26). He's batting .292 and with an on-base percentage of .357.
• Including all qualified hitters in the big leagues, his batting average places him 30th, his on-base percentage ranks 55th, and he is fifth in slugging.
• Alec Burleson has six doubles, three home runs and 12 walks while hitting .278. He's slugging .444 with an on-base percentage of .359.
• He is currently 49th in batting average, 53rd in on-base percentage and 58th in slugging percentage among all qualifying hitters.
• Ivan Herrera a has .387 on-base percentage to pace the Cardinals.
• JJ Wetherholt is hitting .218 with two doubles, three home runs and 15 walks.

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