LSU vs Ole Miss Prediction, Odds, Picks, Best Bets for Week 3 2026

The LSU Tigers are among the college football teams in action on Saturday, up against the Ole Miss Rebels.

Before you place your bet on this game at FanDuel Sportsbook, here are the NCAA football odds and spreads you need to know.

LSU vs Ole Miss Odds & Spread

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• All college football odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: LSU: (-148) | Ole Miss: (+126)
• Spread: LSU: -2.5 (-122) | Ole Miss: +2.5 (100)
• Total: 58.5 -- Over: (-115) | Under: (-105)

LSU vs Ole Miss Betting Trends

• LSU hasn won once against the spread this season.
• LSU has won once ATS (1-1) as a 2.5-point or higher favorite this year.
• Every LSU game has hit the over this year.
• Ole Miss is winless against the spread this year.
• One of Ole Miss' two games has gone over the point total.

LSU vs Ole Miss Prediction & Pick

All college football win probability predictions and picks are according to numberFire.
Prediction: Rebels win (57.4%)

LSU vs Ole Miss Point Spread

Ole Miss is a 2.5-point underdog against LSU. Ole Miss is +100 to cover the spread, and LSU is -122.

LSU vs Ole Miss Over/Under

The LSU-Ole Miss matchup on Sept. 19 has been given an over/under of 58.5 points. The over is -115 and the under is -105.

LSU vs Ole Miss Moneyline

LSU is a -148 favorite on the moneyline, while Ole Miss is a +126 underdog.

LSU vs. Ole Miss Points Insights

LSU vs. Ole Miss Game Info

• Game day: Saturday, September 19, 2026
• Game time: 7:30 p.m. ET
• TV channel: ABC
• Location: Oxford, Mississippi
• Stadium: Vaught-Hemingway Stadium

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Check out even more in-depth LSU vs. Ole Miss analysis on FanDuel Research.