Louisville vs SMU College Basketball Prediction, Odds, Picks, Best Bets for Jan. 31

The No. 20 Louisville Cardinals (14-6, 4-4 ACC) host the SMU Mustangs (15-5, 4-3 ACC) in ACC play at KFC Yum! Center, beginning at 2 p.m. ET on Saturday, January 31, 2026.

Before you place your bet on this matchup at FanDuel Sportsbook, here are the NCAA basketball odds and spreads you need to know.

Louisville vs. SMU Game Info and Odds

• Game day: Saturday, January 31, 2026
• Game time: 2 p.m. ET
• TV channel: ESPN
• Location: Louisville, Kentucky
• Arena: KFC Yum! Center

Louisville vs. SMU Picks and Prediction

All college basketball win probability predictions and picks are according to numberFire.
Prediction: Louisville win (75.6%)

Before you wager on Saturday's Louisville-SMU spread (Louisville -9.5) or total (161.5 points), read the betting trends and insights below.

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Louisville vs. SMU: ATS Betting Stats and Trends

• Louisville has put together an 11-9-0 ATS record so far this year.
• SMU has put together a 9-11-0 record against the spread this season.
• As a 9.5-point underdog or more in 2025-26, SMU is 1-1 against the spread compared to the 6-3 ATS record Louisville racks up as a 9.5-point favorite.
• Against the spread, the Cardinals have played better when playing at home, covering seven times in 12 home games, and two times in six road games.
• Against the spread, the Mustangs have had better results away (3-2-0) than at home (5-8-0).
• Louisville is 3-5-0 against the spread in conference games this season.
• SMU has covered the spread three times in seven ACC games.

Louisville vs. SMU: Moneyline Betting Stats

• Louisville has been victorious in eight, or 72.7%, of the 11 contests it has been chosen as moneyline favorites in this season.
• The Cardinals have not lost in three games this year when favored by -549 or better on the moneyline.
• SMU has won two of the seven games it was the moneyline underdog this season (28.6%).
• The Mustangs have played as a moneyline underdog of +400 or longer in only two games this season, which they lost both.
• The moneyline set for this matchup implies Louisville has a 84.6% chance of walking away with the win.

Louisville vs. SMU Head-to-Head Comparison

• Offensively, Louisville was the 65th-ranked squad in the nation (78.5 points per game) last year. Defensively, it was 89th (69.5 points allowed per game).
• Last year, Louisville was 47th in the nation in rebounds (34.6 per game) and 114th in rebounds allowed (30.2).
• Louisville was 148th in the country in assists (13.9 per game) last year.
• With 10.9 turnovers committed per game and 12.2 turnovers forced last year, Louisville was 150th and 93rd in college basketball, respectively.
• SMU averaged 79.9 points per game (40th-ranked in college basketball) last year, while giving up 71.3 points per contest (152nd-ranked).
• With 34.7 rebounds per game, SMU ranked 43rd in college basketball. It ceded 29 rebounds per contest, which ranked 53rd in college basketball.
• SMU ranked 42nd in college basketball with 15.9 assists per game.
• SMU committed 11.5 turnovers per game (221st-ranked in college basketball) this year, while forcing 12 turnovers per contest (112th-ranked).

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