Louisville vs Pittsburgh College Basketball Prediction, Odds, Picks, Best Bets for Jan. 17

The No. 20 Louisville Cardinals (12-5, 2-3 ACC) visit the Pittsburgh Panthers (8-9, 1-3 ACC) in ACC action at Petersen Events Center, beginning at 8 p.m. ET on Saturday, January 17, 2026.

Before you place your bet on this matchup at FanDuel Sportsbook, here are the NCAA basketball odds and spreads you need to know.

Louisville vs. Pittsburgh Game Info and Odds

• Game day: Saturday, January 17, 2026
• Game time: 8 p.m. ET
• TV channel: ESPN2
• Location: Pittsburgh, Pennsylvania
• Arena: Petersen Events Center

Louisville vs. Pittsburgh Picks and Prediction

All college basketball win probability predictions and picks are according to numberFire.
Prediction: Louisville win (64.3%)

Read the betting insights and trends below before making a wager on Saturday's Louisville-Pittsburgh spread (Louisville -7.5) or total (150.5 points).

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Louisville vs. Pittsburgh: ATS Betting Stats and Trends

• Louisville has compiled a 9-8-0 ATS record so far this year.
• Pittsburgh is 8-9-0 ATS this season.
• Louisville covers the spread when it is a 7.5-point favorite or more 63.6% of the time. That's more often than Pittsburgh covers as an underdog of 7.5 or more (50%).
• When playing at home, the Cardinals sport a better record against the spread (6-5-0) compared to their ATS record in road games (1-3-0).
• The Panthers' winning percentage against the spread at home is .455 (5-6-0). Away, it is .500 (2-2-0).
• Louisville has won once against the spread in conference play this season.
• Pittsburgh has posted two ACC wins against the spread this season.

Louisville vs. Pittsburgh: Moneyline Betting Stats

• Louisville has won in six of the nine contests it has been named as the moneyline favorite in this year.
• The Cardinals have a mark of 4-1 in contests where oddsmakers favor them by -280 or better on the moneyline.
• Pittsburgh has compiled a 2-5 record in games it was listed as the moneyline underdog (winning 28.6% of those games).
• The Panthers have played as a moneyline underdog of +225 or longer in only two games this season, which they lost both.
• The moneyline set for this matchup implies Louisville has a 73.7% chance of coming away with a victory in the contest.

Louisville vs. Pittsburgh Head-to-Head Comparison

• With 78.5 points scored per game and 69.5 points allowed last season, Louisville was 65th in college basketball offensively and 89th defensively.
• Last season, Louisville was 47th in college basketball in rebounds (34.6 per game) and 114th in rebounds conceded (30.2).
• With 13.9 assists per game last year, Louisville was 148th in the country.
• In terms of turnovers, Louisville was 150th in the nation in committing them (10.9 per game) last year. It was 93rd in forcing them (12.2 per game).
• With 75.9 points per game on offense, Pittsburgh ranked 119th in college basketball last year. On defense, it ceded 70.8 points per contest, which ranked 140th in college basketball.
• With 30.6 boards per game, Pittsburgh was 266th in college basketball. It allowed 30.5 rebounds per contest, which ranked 135th in college basketball.
• Last season Pittsburgh ranked 196th in college basketball in assists, averaging 13.4 per game.
• Pittsburgh ranked 45th in the nation with 9.7 turnovers per game last year. Meanwhile, it ranked 140th with 11.7 forced turnovers per game.

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