Louisville vs Indiana Prediction, Odds, & Betting Trends for College Football Week 3 Game

The college football slate on Saturday includes the Louisville Cardinals taking on the Indiana Hoosiers.

We've got you covered, in terms of the most important information about NCAA football betting lines, before you make your wager on FanDuel Sportsbook.

Louisville vs Indiana Odds & Spread

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• All college football odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: Louisville: (-385) | Indiana: (+300)
• Spread: Louisville: -10.5 (-104) | Indiana: +10.5 (-118)
• Total: 50.5 -- Over: (-110) | Under: (-110)

Louisville vs Indiana Betting Trends

• Louisville has one win against the spread this year.
• Louisville has yet to lose ATS (1-0) as a 10.5-point favorite or greater this year.
• One of Louisville's two games this season has gone over the point total.
• Indiana has but one win versus the spread this season.
• Indiana has covered every time (1-0) as a 10.5-point or greater underdog this season.
• Indiana and its opponent have yet to hit the over this season.

Louisville vs Indiana Prediction & Pick

All college football win probability predictions and picks are according to numberFire.
Prediction: Cardinals win (88.4%)

Louisville vs Indiana Point Spread

Indiana is listed as an underdog by 10.5 points (-118 odds), and Louisville, the favorite, is -104 to cover.

Louisville vs Indiana Over/Under

The over/under for the Louisville versus Indiana game on September 16 has been set at 50.5, with -110 odds on the over and -110 odds on the under.

Louisville vs Indiana Moneyline

Looking at the moneyline for Louisville-Indiana, Louisville is the favorite at -385, and Indiana is +300.

Louisville vs. Indiana Points Insights

• The Cardinals' average implied point total last season was 1.8 fewer points than their implied total in Saturday's game (29.2 implied points on average compared to 31 implied points in this game).
• Last year, Louisville recorded more than 31 points in six games.
• The average implied point total last season for the Hoosiers (34.7) is 14.7 more points than the team's implied total in this matchup (20).

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Check out even more in-depth Louisville vs. Indiana analysis on FanDuel Research.