Louisville vs Clemson College Basketball Prediction, Odds, Picks, Best Bets for Feb. 28

The Clemson Tigers (20-8, 10-5 ACC) will attempt to break a four-game losing streak when they host the Louisville Cardinals (20-8, 9-6 ACC) on February 28, 2026 at Littlejohn Coliseum.

Before you place your bet on this game at FanDuel Sportsbook, here are the NCAA basketball odds and spreads you need to know.

Louisville vs. Clemson Game Info and Odds

• Game day: Saturday, February 28, 2026
• Game time: 2 p.m. ET
• TV channel: ESPN2
• Location: Clemson, South Carolina
• Arena: Littlejohn Coliseum

Louisville is a 1.5-point favorite against Clemson on Saturday and the over/under is set at 146.5 points. Below are some betting trends and insights before you decide to wager on the contest.

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Louisville vs. Clemson: ATS Betting Stats and Trends

• Louisville has put together a 14-14-0 record against the spread this season.
• Clemson has compiled a 15-13-0 ATS record so far this year.
• Clemson covers the spread when it is a 1.5-point underdog or more 100% of the time. That's more often than Louisville covers as a favorite of 1.5 or more (56%).
• Against the spread, the Cardinals have played better at home, covering nine times in 16 home games, and two times in nine road games.
• The Tigers' winning percentage against the spread at home is .429 (6-8-0). Away, it is .700 (7-3-0).
• Louisville is 5-10-0 against the spread in conference play this season.
• Clemson has covered the spread nine times in 15 ACC games.

Louisville vs. Clemson: Moneyline Betting Stats

• Louisville has come away with 14 wins in the 19 contests it has been listed as the moneyline favorite in this season.
• The Cardinals have a win-loss record of 14-5 when favored by -142 or better by sportsbooks this year.
• Clemson has not yet won a game it played as the moneyline underdog this season, going 0-3.
• The Tigers have played three times as a moneyline underdog with odds of +118 or longer, and lost each game.
• The moneyline set for this matchup implies Louisville has a 58.7% chance of coming away with a victory in the contest.

Louisville vs. Clemson Head-to-Head Comparison

• Louisville's +403 scoring differential (outscoring opponents by 14.4 points per game) is a result of scoring 86.4 points per game (16th in college basketball) while giving up 72 per contest (126th in college basketball).
• Mikel Brown Jr.'s 18.9 points per game lead Louisville and are 56th in college basketball.
• Clemson puts up 74.5 points per game (221st in college basketball) while allowing 65.6 per contest (18th in college basketball). It has a +250 scoring differential and outscores opponents by 8.9 points per game.
• RJ Godfrey is 797th in college basketball with a team-high 11.5 points per game.
• The Cardinals pull down 37.3 rebounds per game (13th in college basketball) while conceding 30.3 per contest to their opponents. They outrebound opponents by 7.0 boards per game.
• Sananda Fru paces the team with 6.4 rebounds per game (230th in college basketball play).
• The Tigers prevail in the rebound battle by an average of 2.9 boards. They are recording 31.9 rebounds per game (195th in college basketball) compared to their opponents' 29.
• Carter Welling averages 5.6 rebounds per game (382nd in college basketball) to lead the Tigers.
• Louisville scores 106.8 points per 100 possessions (24th in college basketball), while allowing 89 points per 100 possessions (49th in college basketball).
• The Tigers rank 75th in college basketball with 102.5 points scored per 100 possessions, and 62nd defensively with 90.2 points conceded per 100 possessions.

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