Iowa vs Iowa State Prediction, Odds, Picks, Best Bets for Week 2 2026

The college football slate on Saturday includes the Iowa Hawkeyes facing the Iowa State Cyclones.

Before you make your wager on FanDuel Sportsbook, we've got you covered with all the latest NCAA football betting insights.

Iowa vs Iowa State Odds & Spread

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• All college football odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: Iowa: (-690) | Iowa State: (+480)
• Spread: Iowa: -13.5 (-122) | Iowa State: +13.5 (100)
• Total: 40.5 -- Over: (-112) | Under: (-108)

Iowa vs Iowa State Betting Trends

• Iowa hasn't lost a game against the spread this year.
• Iowa has covered every time (1-0) as a 13.5-point favorite or greater this year.
• Iowa State has no wins against the spread this year.
• None of Iowa State's one games has gone over the point total in 2026.

Iowa vs Iowa State Prediction & Pick

All college football win probability predictions and picks are according to numberFire.
Prediction: Hawkeyes win (77%)

Iowa vs Iowa State Point Spread

Iowa State is the underdog by 13.5 points against Iowa. Iowa State is -122 to cover the spread, and Iowa is +100.

Iowa vs Iowa State Over/Under

The over/under for the Iowa versus Iowa State game on Sept. 12 has been set at 40.5, with -112 odds on the over and -108 odds on the under.

Iowa vs Iowa State Moneyline

Looking at the moneyline for Iowa State-Iowa, Iowa State is the underdog at +480, and Iowa is -690.

Iowa vs. Iowa State Points Insights

• The average implied total for the Hawkeyes last season was 27.5 points, 0.5 more points than their implied total of 27 points in Saturday's game.
• The average implied point total last season for the Cyclones (29.3) is 15.3 more points than the team's implied total in this matchup (14).

Iowa vs. Iowa State Game Info

• Game day: Saturday, September 12, 2026
• Game time: 7:30 p.m. ET
• TV channel: NBC/Peacock
• Location: Iowa City, Iowa
• Stadium: Kinnick Stadium

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Check out even more in-depth Iowa vs. Iowa State analysis on FanDuel Research.