Indiana vs USC Prediction, Odds, Picks, Best Bets for Week 11 2026

The Indiana Hoosiers will take on the USC Trojans in college football action on Saturday.

Before you make your wager on FanDuel Sportsbook, we've got you covered, in terms of the vital info about today's NCAA football betting odds.

Indiana vs USC Odds & Spread

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• All college football odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: Indiana: (-319) | USC: (+260)
• Spread: Indiana: -8.5 (-110) | USC: +8.5 (-110)
• Total: 50.5 -- Over: (-110) | Under: (-110)

Indiana vs USC Betting Trends

• Indiana has one win against the spread this year.
• Indiana has won once ATS (1-6) as an 8.5-point or higher favorite this season.
• This year, three of Indiana's nine games have hit the over.
• USC is 3-6-0 against the spread this year.
• There have been four USC games (out of nine) that went over the total this season.

Indiana vs USC Prediction & Pick

All college football win probability predictions and picks are according to numberFire.
Prediction: Hoosiers win (85.1%)

Indiana vs USC Point Spread

USC is a 8.5-point underdog against Indiana. USC is -110 to cover the spread, and Indiana is -110.

Indiana vs USC Over/Under

A total of 50.5 points has been set for the Indiana-USC game on Nov. 14, with the over available at -110 and the under at -110.

Indiana vs USC Moneyline

USC is the underdog, +260 on the moneyline, while Indiana is a -319 favorite.

Indiana vs. USC Points Insights

Indiana vs. USC Game Info

• Game day: Saturday, November 14, 2026
• Game time: 3:30 p.m. ET
• TV channel: CBS
• Location: Bloomington, Indiana
• Stadium: Memorial Stadium (Bloomington, IN)

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Check out even more in-depth Indiana vs. USC analysis on FanDuel Research.