Indiana vs Purdue Prediction, Odds, Picks, Best Bets for Week 14 2025

In college football action on Friday, the Indiana Hoosiers face the Purdue Boilermakers.

Before you place your bet on this game at FanDuel Sportsbook, here are the NCAA football odds and spreads you need to know.

Indiana vs Purdue Odds & Spread

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• All college football odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: Indiana: (-10000) | Purdue: (+2400)
• Spread: Indiana: -28.5 (-105) | Purdue: +28.5 (-115)
• Total: 53.5 -- Over: (-105) | Under: (-115)

Indiana vs Purdue Betting Trends

• Indiana has covered the spread six times in 11 games.
• Indiana has two wins ATS (2-1) as a 28.5-point or higher favorite in 2025.
• Out of 11 Indiana games so far this season, seven have gone over the total.
• Purdue has covered the spread five times in 11 games.
• Purdue has covered every time (1-0) as a 28.5-point or greater underdog this year.
• This year, three of Purdue's 11 games have hit the over.

Indiana vs Purdue Prediction & Pick

All college football win probability predictions and picks are according to numberFire.
Prediction: Hoosiers win (97.9%)

Indiana vs Purdue Point Spread

Indiana is a 28.5-point favorite against Purdue. Indiana is -105 to cover the spread, and Purdue is -115.

Indiana vs Purdue Over/Under

A combined point total of 53.5 has been set for Indiana-Purdue on Nov. 28, with the over at -105 and the under at -115.

Indiana vs Purdue Moneyline

Purdue is a +2400 underdog on the moneyline, while Indiana is a -10000 favorite.

Indiana vs. Purdue Points Insights

Indiana vs. Purdue Game Info

• Game day: Friday, November 28, 2025
• Game time: 7:30 p.m. ET
• TV channel: NBC
• Location: West Lafayette, Indiana
• Stadium: Ross-Ade Stadium

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Check out even more in-depth Indiana vs. Purdue analysis on FanDuel Research.