Illinois vs Northwestern Prediction, Odds, Picks, Best Bets for Week 14 2025

The Saturday schedule in college football includes a matchup between the Illinois Fighting Illini and the Northwestern Wildcats.

Before you make your wager on FanDuel Sportsbook, we've got you covered, in terms of the vital information regarding today's NCAA football betting odds.

Illinois vs Northwestern Odds & Spread

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• All college football odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: Illinois: (-260) | Northwestern: (+215)
• Spread: Illinois: -6.5 (-124) | Northwestern: +6.5 (102)
• Total: 45.5 -- Over: (-115) | Under: (-105)

Illinois vs Northwestern Betting Trends

• Against the spread, Illinois is 7-4-0 this year.
• As 6.5-point favorites or more, Illinois is 5-1 against the spread.
• Out of 11 Illinois games so far this season, five have hit the over.
• Northwestern is 7-4-0 against the spread this year.
• Northwestern has an ATS record of 4-1 as 6.5-point underdogs or more.
• There have been five Northwestern games (out of 11) that hit the over this year.

Illinois vs Northwestern Prediction & Pick

All college football win probability predictions and picks are according to numberFire.
Prediction: Fighting Illini win (75.4%)

Illinois vs Northwestern Point Spread

Northwestern is listed as an underdog by 6.5 points (+102 odds), and Illinois, the favorite, is -124 to cover.

Illinois vs Northwestern Over/Under

The Illinois-Northwestern matchup on Nov. 29 has been given an over/under of 45.5 points. The over is -115 and the under is -105.

Illinois vs Northwestern Moneyline

Illinois is a -260 favorite on the moneyline, while Northwestern is a +215 underdog.

Illinois vs. Northwestern Points Insights

Illinois vs. Northwestern Game Info

• Game day: Saturday, November 29, 2025
• Game time: 7:30 p.m. ET
• TV channel: FOX
• Location: Champaign, Illinois
• Stadium: Memorial Stadium (Champaign, IL)

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Check out even more in-depth Illinois vs. Northwestern analysis on FanDuel Research.