Houston vs Purdue Basketball Prediction, Odds, Picks, Best Bets for NCAA Tournament Sweet 16

The No. 4-seed Purdue Boilermakers (24-11) are ready for a Sweet 16 matchup against the No. 1 Houston Cougars (32-4) on Friday at 10:09 p.m. ET as the NCAA Tournament continues at Lucas Oil Stadium airing on TBS.

Before you place your bet on this game at FanDuel Sportsbook, here are the NCAA basketball odds and spreads you need to know.

Houston vs. Purdue Game Info and Odds

• Game day: Friday, March 28, 2025
• Game time: 10:09 p.m. ET
• TV channel: TBS
• Location: Indianapolis, Indiana
• Arena: Lucas Oil Stadium

Houston vs. Purdue Picks and Prediction

All college basketball win probability predictions and picks are according to numberFire.
Prediction: Houston win (69.7%)

Take a look at some betting trends for Houston (-8.5) versus Purdue on Friday. The over/under has been set at 133.5 points for this game.

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Houston vs. Purdue: ATS Betting Stats and Trends

• Houston has put together a 20-15-0 record against the spread this season.
• Purdue has put together a 19-16-0 record against the spread this year.
• Houston covers the spread when it is an 8.5-point favorite or more 57.7% of the time. That's more often than Purdue covers as an underdog of 8.5 or more (never covered this season).
• The Cougars have a worse record against the spread in home games (10-7-0) than they do in road games (7-3-0).
• In 2024-25 against the spread, the Boilermakers have a better winning percentage at home (.625, 10-6-0 record) than on the road (.545, 6-5-0).

Houston vs. Purdue: Moneyline Betting Stats

• Houston has been victorious in 30, or 88.2%, of the 34 contests it has been chosen as moneyline favorites in this season.
• This season, the Cougars have been victorious 23 times in 25 chances when named as a favorite of at least -385 or better on the moneyline.
• Purdue has won two of the eight games it was listed as the moneyline underdog this season (25%).
• The Boilermakers have played as a moneyline underdog of +290 or longer in only one game this season, which they lost.
• The moneyline set for this matchup implies Houston has a 79.4% chance of walking away with the win.

Houston vs. Purdue Head-to-Head Comparison

• Houston is outscoring opponents by 16.1 points per game with a +578 scoring differential overall. It puts up 74.5 points per game (154th in college basketball) and gives up 58.4 per outing (first in college basketball).
• LJ Cryer's 15.6 points per game lead Houston and rank 222nd in the nation.
• Purdue puts up 77.7 points per game (79th in college basketball) while allowing 70.6 per outing (134th in college basketball). It has a +250 scoring differential and outscores opponents by 7.1 points per game.
• Trey Kaufman-Renn leads Purdue, averaging 20.3 points per game (14th in college basketball).
• The Cougars rank 118th in the nation at 33 rebounds per game. That's 6.6 more than the 26.4 their opponents average.
• J'wan Roberts leads the Cougars with 6.3 rebounds per game (259th in college basketball play).
• The Boilermakers pull down 30.1 rebounds per game (291st in college basketball) while allowing 28.2 per contest to opponents. They outrebound opponents by 1.9 boards per game.
• Kaufman-Renn tops the team with 6.5 rebounds per game (234th in college basketball).
• Houston ranks 32nd in college basketball with 102.6 points scored per 100 possessions, and second in college basketball defensively with 80.5 points conceded per 100 possessions.
• The Boilermakers average 104.6 points per 100 possessions (21st in college basketball), while giving up 95 points per 100 possessions (226th in college basketball).

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