Houston vs LSU Prediction, Odds, Picks, Best Bets for Texas Bowl 2025

On Saturday in college football, the Houston Cougars are playing the LSU Tigers.

Before you make your wager on FanDuel Sportsbook, we've got you covered with all the latest NCAA football betting insights.

Houston vs LSU Odds & Spread

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• All college football odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: Houston: (-134) | LSU: (+112)
• Spread: Houston: -2.5 (-115) | LSU: +2.5 (-105)
• Total: 41.5 -- Over: (-110) | Under: (-110)

Houston vs LSU Betting Trends

• Houston has beaten the spread eight times in 12 games.
• As 2.5-point favorites or more, Houston is 4-2 against the spread.
• This season, seven of Houston's 12 games have go over the point total.
• LSU has four wins in 12 contests against the spread this year.
• As a 2.5-point underdog or more, LSU has two wins ATS (2-2).
• Of 12 LSU games so far this season, three have hit the over.

Houston vs LSU Point Spread

Houston is favored by 2.5 points over LSU. Houston is -115 to cover the spread, with LSU being -105.

Houston vs LSU Over/Under

An over/under of 41.5 has been set for Houston-LSU on Dec. 27, with the over being -110 and the under -110.

Houston vs LSU Moneyline

Looking at the moneyline for Houston-LSU, Houston is the favorite at -134, and LSU is +112.

Houston vs. LSU Points Insights

Houston vs. LSU Game Info

• Game day: Saturday, December 27, 2025
• Game time: 9:15 p.m. ET
• TV channel: ESPN
• Location: Houston, Texas
• Stadium: NRG Stadium

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Check out even more in-depth Houston vs. LSU analysis on FanDuel Research.